2025
Sinonasal Presentations of Immunoglobulin G4‐Related Disease: A Scoping Review
Farrokh F, Rimmer R. Sinonasal Presentations of Immunoglobulin G4‐Related Disease: A Scoping Review. The Laryngoscope 2025 PMID: 40231759, DOI: 10.1002/lary.32196.Peer-Reviewed Original ResearchSinonasal regionSinonasal manifestationsOrgan systemsImmunoglobulin G4-related diseaseFrequent site of involvementSite of involvementClassification criteriaSinonasal presentationSinonasal involvementMaxillary sinusEthmoid sinusIgG4RDFrequent siteClinical symptomsNasal cavityRayyan platformWeb of ScienceImmune diseasesLiterature searchSimultaneous involvementSinusPatientsJBI guidelinesDiagnosisInvolvement
2024
Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis
Tang H, Du S, Niu Z, Zhang D, Tang Z, Chen H, Chen Z, Zhang M, Xu Y, Sun Y, Fu X, Norback D, Shao J, Zhao Z. Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis. BMC Microbiology 2024, 24: 505. PMID: 39614169, PMCID: PMC11606197, DOI: 10.1186/s12866-024-03668-9.Peer-Reviewed Original ResearchConceptsSpecies levelBacterial speciesAR childrenNasal cavityMethodsIn this case–control studyBody sitesControl groupBacterial diversityCase-control studyB-diversityOral swab samplesS. epidermidisStaphylococcus epidermidisStaphylococcus aureusBacterial characterizationMicrobesAllergic rhinitisSpeciesHealthy subjectsBackgroundAllergic rhinitisSwab samplesHealthy onesConclusionsOur studyMicroorganismsRhinitisInflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2
Martin-Lopez E, Brennan B, Mao T, Spence N, Meller S, Han K, Yahiaoui N, Wang C, Iwasaki A, Greer C. Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2. ENeuro 2024, 11: eneuro.0106-24.2024. PMID: 38834299, PMCID: PMC11185043, DOI: 10.1523/eneuro.0106-24.2024.Peer-Reviewed Original ResearchOlfactory bulbOlfactory epitheliumPiriform cortexOlfactory tractOlfactory systemSARS-CoV-2Projection neuronsMyelination defectsOlfactory sensory neuronsLateral olfactory tractLoss of olfactionRespiratory epithelial cellsLamina propria macrophagesSARS-CoV-2 infectionInfected SCDays of infectionIntegrity of myelinOlfactory dysfunctionInfected microgliaSensitive to infectionOlfactory deficitsSensory neuronsSustentacular cellsNasal cavityNeuronal conduction
2022
Nasal Cavity and Paranasal Sinus Tumors
Fan M, Yu Y, Kang J, Lee N. Nasal Cavity and Paranasal Sinus Tumors. Practical Guides In Radiation Oncology 2022, 87-98. DOI: 10.1007/978-3-030-99590-4_7.Peer-Reviewed Original ResearchParanasal sinusesNasal cavityTumor typesTarget delineationExperienced multidisciplinary teamSquamous cell carcinomaParanasal sinus tumorsDifferent natural historyCentral nervous systemMedical oncologistsSinus tumorAccurate target delineationCell carcinomaOptimal careNeck surgeonsCystic carcinomaNervous systemDiverse tumor typesMultidisciplinary teamRadiation oncologistsSkull baseNatural historyPatientsCarcinomaOncologistsSustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus
Xue Y, Gursky Z, Monte B, Koundal S, Liu X, Lee H, Michurina TV, Mellanson KA, Zhao L, Nemajerova A, Kahle KT, Takemaru KI, Enikolopov G, Peunova NI, Benveniste H. Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus. Fluids And Barriers Of The CNS 2022, 19: 20. PMID: 35248089, PMCID: PMC8898469, DOI: 10.1186/s12987-022-00319-x.Peer-Reviewed Original ResearchConceptsGlymphatic transportIntracranial pressureMagnetic resonance imagingNasal cavityCribriform plateMouse modelFluid homeostasisOlfactory bulb hypoplasiaDistinct mouse modelsNormal intracranial pressureAquaporin-4 expressionKnock-out (KO) miceWild-type littermatesConditional knockout miceChronic rhinitisCommon findingSeparate cohortAQP4 expressionAQP4 polarizationKnockout miceHydrocephalusResonance imagingConclusionsThe combinationGadoteric acidBrain morphometry
2021
Sinonasal Glomangiopericytoma: Review of Imaging Appearance and Clinical Management Update for a Rare Sinonasal Neoplasm.
Al-Jobory YM, Pan Z, Manes RP, Omay SB, Ikuta I. Sinonasal Glomangiopericytoma: Review of Imaging Appearance and Clinical Management Update for a Rare Sinonasal Neoplasm. The Yale Journal Of Biology And Medicine 2021, 94: 593-597. PMID: 34970096, PMCID: PMC8686777.Peer-Reviewed Original ResearchConceptsWorld Health OrganizationParanasal sinusesNasal cavityClinical management updateRare sinonasal neoplasmSlight female predominanceLow malignant potentialComplete surgical excisionNon-specific appearanceCase of glomangiopericytomaDecade of ageAggressive treatmentExcellent prognosisSinus massFemale predominanceLocal excisionLocal recurrenceMale patientsSurgical excisionRare tumorMalignant potentialImaging appearancesSinonasal neoplasmsSinonasal cavityTumor extentLive imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen CB, Dekaban GA, Dikeakos JD, Bruce EA, Kaufmann DE, Stamatatos L, McGuire AT, Richard J, Pazgier M, Bjorkman PJ, Mothes W, Finzi A, Kumar P, Uchil PD. Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy. Immunity 2021, 54: 2143-2158.e15. PMID: 34453881, PMCID: PMC8372518, DOI: 10.1016/j.immuni.2021.08.015.Peer-Reviewed Original ResearchConceptsCOVID-19 convalescent subjectsSARS-CoV-2 infectionBioluminescence imagingK18-hACE2 miceLive bioluminescence imagingNatural killer cellsFc effector functionsSARS-CoV-2Convalescent subjectsKiller cellsPotent NAbsImmune protectionInflammatory responseEffector functionsNasal cavityNaB treatmentOptimal efficacyFc functionDepletion studiesMiceNAbsCOVID-19Direct neutralizationInfectionAntibodiesAerosol and Droplet Risk of Common Otolaryngology Clinic Procedures
Boorgu DSSK, Dharmarajan H, Sim ES, Goyal L, Freiser ME, Weinstock M, Whelan R, Corcoran TE, Jabbour N, Wang E, H. D. Aerosol and Droplet Risk of Common Otolaryngology Clinic Procedures. Annals Of Otology Rhinology & Laryngology 2021, 130: 1245-1253. PMID: 33730891, DOI: 10.1177/00034894211000502.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentNasal endoscopyClinic proceduresExternal earRigid nasal endoscopyPositive controlOpen suctioningFluorescent tracersNasal suctionRetrograde intubationBaseline riskNasal cavityAerodynamic diameterProtective equipmentCadaveric headsEndoscopyAdditional riskCOVID-19 eraEndonasal drillingClinical proceduresSuctioningRiskVitamin B2BreathingDroplet contamination
2020
Morphological Basis for Airway Surgical Intervention in Apert Syndrome
Lu X, Forte AJ, Park KE, Allam O, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Morphological Basis for Airway Surgical Intervention in Apert Syndrome. Annals Of Plastic Surgery 2020, 87: 59-64. PMID: 34133365, DOI: 10.1097/sap.0000000000002601.Peer-Reviewed Original ResearchConceptsApert syndrome patientsPharyngeal airway volumeComputed tomography scanSyndrome patientsApert syndromeAirway volumeSurgical interventionTomography scanNasal cavityPreoperative computed tomography scansAirway volume changesAge-related subgroupsYears of ageMonths of agePosition of maxillaGrowth of mandibleAirway compromiseNasopharyngeal airwayPharyngeal airwayNasal airwayIntergonial widthSyndromeAirwayPatientsAnteroposterior lengthAirway Development Relevant to Cranial Vault Suture Synostosis Subtype in Apert Syndrome
Lu X, Forte A, Park K, Allam O, Steinbacher D, Alperovich M, Passos-Bueno M, Tonello C, Alonso N, Persing J. Airway Development Relevant to Cranial Vault Suture Synostosis Subtype in Apert Syndrome. FACE 2020, 1: 89-96. DOI: 10.1177/2732501620973030.Peer-Reviewed Original ResearchPharyngeal airwayAirway volumeNasal airwayApert patientsCT scanNasal cavityCross-sectional areaApert syndromeSuture synostosisNasopharyngeal airway volumePharyngeal airway volumeAirway volume changesDecreased cross-sectional areaType IIIBilateral coronal synostosisType IIAirway developmentSyndrome subtypesCranial base angulationAirwayEstablished classification systemPatientsSurgical planningSectional areaCoronal synostosisNovel Use of Vitamin B2 as a Fluorescent Tracer in Aerosol and Droplet Contamination Models in Otolaryngology
Sim ES, Dharmarajan H, Boorgu DSSK, Goyal L, Weinstock M, Whelan R, Freiser ME, Corcoran TE, Jabbour N, Wang E, H. D. Novel Use of Vitamin B2 as a Fluorescent Tracer in Aerosol and Droplet Contamination Models in Otolaryngology. Annals Of Otology Rhinology & Laryngology 2020, 130: 280-285. PMID: 32795090, PMCID: PMC7429918, DOI: 10.1177/0003489420949588.Peer-Reviewed Original ResearchConceptsSmall dropletsEndonasal drillingParticle dispersion patternsNasal cavityVitamin B2Cadaveric headsFluorescent tracersDifferent fluorescent tracersAverage aerodynamic diameterCollection chamberUV lightDropletsNasopharyngeal mucosaSafety profileCascade impactorOtolaryngology proceduresContamination modelDrillingGreen dyeCOVID-19 eraHuman subjectsOutcomes and toxicities of definitive radiotherapy and reirradiation using 3‐dimensional conformal or intensity‐modulated (pencil beam) proton therapy for patients with nasal cavity and paranasal sinus malignancies
Fan M, Kang JJ, Lee A, Fan D, Wang H, Kitpanit S, Fox P, Sine K, Mah D, McBride SM, Tsai CJ, Riaz N, Dunn LA, Sherman EJ, Michel L, Singh B, Ganly I, Wong RJ, Boyle JO, Cohen MA, Lee NY. Outcomes and toxicities of definitive radiotherapy and reirradiation using 3‐dimensional conformal or intensity‐modulated (pencil beam) proton therapy for patients with nasal cavity and paranasal sinus malignancies. Cancer 2020, 126: 1905-1916. PMID: 32097507, PMCID: PMC7304541, DOI: 10.1002/cncr.32776.Peer-Reviewed Original ResearchConceptsGrade 3 toxicityRadiation-naive patientsIntensity-modulated proton therapyLate grade 3 toxicityParanasal sinus cancerLocal controlNasal cavitySinus cancerAcute grade 3 toxicityGray relative biological effectivenessProton therapyMore grade 1Paranasal sinus malignanciesRemarkable local controlDisease-free survivalInferior local controlOverall survival rateDefinitive radiotherapyConsecutive patientsSinus malignanciesMedian dosesHigher complicationsDistant controlTherapeutic ratioPatientsOrthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI
Sanganahalli BG, Baker KL, Thompson GJ, Herman P, Shepherd GM, Verhagen JV, Hyder F. Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI. NeuroImage 2020, 212: 116664. PMID: 32087375, PMCID: PMC9362851, DOI: 10.1016/j.neuroimage.2020.116664.Peer-Reviewed Original ResearchConceptsRat olfactory bulbOlfactory bulbWhole olfactory bulbOlfactory receptor neuronsFunctional MRINasal cavityRetronasal stimuliGlomerular sheetDorsal-medial regionsDelivery routeRetronasal stimulationSimilar response amplitudesGlomerular activityFMRI activation mapsSame odorReceptor neuronsDorsal regionNeural responsesOdor representationsLateral regionsSame odorantOrthonasalUnderlie differencesResponse amplitudeResponse patterns
2019
Airway Analysis in Apert Syndrome.
Forte AJ, Lu X, Hashim PW, Steinbacher DM, Alperovich M, Persing JA, Alonso N. Airway Analysis in Apert Syndrome. Plastic & Reconstructive Surgery 2019, 144: 704-709. PMID: 31461034, DOI: 10.1097/prs.0000000000005937.Peer-Reviewed Original ResearchConceptsPosterior nasal spineApert syndromeNasal spineTomographic scanPharyngeal airway volumeRespiratory insufficiencyAirway compromiseAirway volumeAirway spaceRespiratory impairmentClinical managementAirway analysisPosterior airwayNasal cavityDisease comorbiditiesPatientsSyndromeSkull baseNasal measurementsSpine distanceStatistical significanceMidfacial deformitiesSpineAirwayPharyngeal regionTiming of surgery and adjuvant radiation therapy for sinonasal malignancies: Effect of surgical approach
Xiao R, Joshi RR, Husain Q, Cracchiolo JR, Lee N, Tsai J, Yu Y, Chen L, Kang JJ, McBride S, Riaz N, Roman BR, Ganly I, Tabar V, Gray ST, Cohen MA. Timing of surgery and adjuvant radiation therapy for sinonasal malignancies: Effect of surgical approach. Head & Neck 2019, 41: 3551-3563. PMID: 31294897, PMCID: PMC6742559, DOI: 10.1002/hed.25873.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoma, Squamous CellCombined Modality TherapyDatabases, FactualDisease-Free SurvivalEndoscopyFemaleHumansKaplan-Meier EstimateLinear ModelsMaleMiddle AgedOtorhinolaryngologic Surgical ProceduresParanasal Sinus NeoplasmsPropensity ScoreRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTime FactorsConceptsSquamous cell carcinomaRadiation therapyEndoscopic surgeryPropensity score-matched analysisAdjuvant radiation therapyNational Cancer DatabasePostoperative radiation therapyKaplan-Meier methodTiming of surgeryDay of surgeryShorter postoperative timeMultivariable linear regressionOverall survivalPostoperative timeSinonasal malignanciesCell carcinomaSurgical approachNeck cancerCancer DatabaseParanasal sinusesSurvival advantageNasal cavitySurgeryPatientsExtended OSPhosphaturic mesenchymal tumor of the nasal cavity: Clinicopathologic correlation is essential for diagnosis
Kerr A, Rimmer R, Rosen M, Evans J, Tuluc M, Mardekian S. Phosphaturic mesenchymal tumor of the nasal cavity: Clinicopathologic correlation is essential for diagnosis. Human Pathology Reports 2019, 15: 33-36. DOI: 10.1016/j.ehpc.2018.10.013.Peer-Reviewed Original ResearchPhosphaturic mesenchymal tumorMesenchymal tumorsFibroblast growth factor 23Growth factor 23Nasal cavity massDistinct clinical presentationsLaboratory abnormalitiesOncogenic osteomalaciaClinical presentationFactor 23Patient's symptomsPathologic findingsCavity massHistopathologic examinationRare neoplasmClinicopathologic correlationNasal cavityFGF23 mRNATumorsTumor cellsSymptomsDiagnosisSitu hybridizationResectionOsteomalaciaA Cadaveric Model for Measuring Continuous Positive Airway Pressure (CPAP) in the Nasal Cavity and Paranasal Sinuses: A Proof of Concept Study
Rimmer R, Chitguppi C, Garcia H, Koszewski I, Nyquist G, Rosen M, Huntley C, Evans J, Rabinowitz M. A Cadaveric Model for Measuring Continuous Positive Airway Pressure (CPAP) in the Nasal Cavity and Paranasal Sinuses: A Proof of Concept Study. Journal Of Neurological Surgery Part B Skull Base 2019, 80: s1-s244. DOI: 10.1055/s-0039-1679476.Peer-Reviewed Original Research
2017
NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
Peri S, Izumchenko E, Schubert AD, Slifker MJ, Ruth K, Serebriiskii IG, Guo T, Burtness BA, Mehra R, Ross EA, Sidransky D, Golemis EA. NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis. Nature Communications 2017, 8: 1772. PMID: 29176703, PMCID: PMC5701248, DOI: 10.1038/s41467-017-01877-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCohort StudiesFemaleGene Expression Regulation, NeoplasticHistone MethyltransferasesHistone-Lysine N-MethyltransferaseHumansIntracellular Signaling Peptides and ProteinsLaryngeal NeoplasmsMaleMiddle AgedMutationNuclear ProteinsPrognosisRepressor ProteinsSquamous Cell Carcinoma of Head and NeckConceptsUseful clinical metricSquamous cell carcinomaLaryngeal cancer patientsPoor overall survivalIndependent validation cohortDistinct prognostic outcomesMolecular prognostic biomarkersOverall survivalCancer Genome AtlasFavorable prognosisBetter prognosisValidation cohortCell carcinomaCancer patientsLaryngeal tumorsLaryngeal cancerPrognostic outcomesTreatment stratificationPrognostic biomarkerNasal cavityOral cavityHigh recurrenceAnatomical sitesPatient stratificationCancer subtypes
2015
Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells
Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, Turner PE, Pyle AM, Iwasaki A. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 827-832. PMID: 25561542, PMCID: PMC4311828, DOI: 10.1073/pnas.1411030112.Peer-Reviewed Original ResearchConceptsAirway cellsCommon cold virusViral replicationIFN inductionRecombinant type I IFNMouse airway epithelial cellsCold virusAirway epithelial cellsInduction of ISGsType I IFNPrimary airway cellsCore body temperatureType IAntiviral defense responseLike receptorsI IFNNasal cavityMAVS proteinHuman rhinovirusSustained increaseInnate defensePoly IGenetic deficiencyRobust inductionRhinovirus
2013
Effect of greater palatine canal injection on estimated blood loss during endoscopic sinus surgery
Eloy J, Kovalerchik O, Bublik M, Ruiz J, Casiano R. Effect of greater palatine canal injection on estimated blood loss during endoscopic sinus surgery. American Journal Of Otolaryngology 2013, 35: 1-4. PMID: 23529136, DOI: 10.1016/j.amjoto.2013.02.011.Peer-Reviewed Original ResearchConceptsEndoscopic sinus surgeryGreater palatine canalPresence of polypsOperative timeCT stageBlood lossSinus surgeryRevision surgeryCombined groupControl groupSPSS version 16Higher EBLSurgery leadEndoscopic stageGreater EBLOperative reportsStudy groupCT scanNasal cavitySurgeryCombined injectionDemographic dataPalatine canalVersion 16Safe method
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