2015
Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells
Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, Turner PE, Pyle AM, Iwasaki A. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 827-832. PMID: 25561542, PMCID: PMC4311828, DOI: 10.1073/pnas.1411030112.Peer-Reviewed Original ResearchConceptsAirway cellsCommon cold virusViral replicationIFN inductionRecombinant type I IFNMouse airway epithelial cellsCold virusAirway epithelial cellsInduction of ISGsType I IFNPrimary airway cellsCore body temperatureType IAntiviral defense responseLike receptorsI IFNNasal cavityMAVS proteinHuman rhinovirusSustained increaseInnate defensePoly IGenetic deficiencyRobust inductionRhinovirus
2010
TLR3 Signaling Is Required For Human Rhinovirus (HRV)-Induced Airways Neutrophilic Inflammation And Hyperresponsiveness But Not Viral Clearance In Experimentally-Infected Mice
Wang Q, Gosangi B, Bowman E, Zhao Y, Nagarkar D, Hershenson M. TLR3 Signaling Is Required For Human Rhinovirus (HRV)-Induced Airways Neutrophilic Inflammation And Hyperresponsiveness But Not Viral Clearance In Experimentally-Infected Mice. 2010, a6778-a6778. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6778.Peer-Reviewed Original Research
2009
Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age
Piotrowska Z, Vázquez M, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age. The Pediatric Infectious Disease Journal 2009, 28: 25-29. PMID: 19057454, PMCID: PMC4639321, DOI: 10.1097/inf.0b013e3181861da0.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusHRV-positive childrenHuman rhinovirusSyncytial virusAge groupsDiagnostic laboratoriesRespiratory tract diseaseMajor respiratory pathogenRate of infectionYears of ageSimilar age groupAsymptomatic childrenRespiratory specimenAsymptomatic groupRespiratory infectionsHRV infectionHospitalization ratesPolymerase chain reactionTract diseaseRespiratory pathogensHRV isolatesMajor causeStudy periodSymptomsInfection
2008
Human Bocavirus: a Newly Discovered Human Parvovirus
Kahn J, Tattersall P. Human Bocavirus: a Newly Discovered Human Parvovirus. 2008, 21-38. DOI: 10.1128/9781555815592.ch2.Peer-Reviewed Original ResearchSevere acute respiratory syndrome-associated coronavirusPopulation-based surveillance studyRespiratory tract infectionsNew respiratory virusesRespiratory viral pathogensCause of morbiditySerum of childrenRespiratory tract diseaseViral pathogensNovel human polyomavirusesHBoV DNATract infectionsRespiratory virusesRespiratory secretionsHuman bocavirusHuman metapneumovirusRespiratory specimensTract diseaseHBoVViral life cycleSurveillance studyHuman polyomavirusesHuman rhinovirusHuman parvovirusPneumonia
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