2024
Seven-tesla magnetic resonance imaging of the nervus terminalis, olfactory tracts, and olfactory bulbs in COVID-19 patients with anosmia and hypogeusia
Kirsch C, Khurram S, Lambert D, Belani P, Pawha P, Alipour A, Rashid S, Herb M, Saju S, Zhu Y, Delman B, Lin H, Balchandani P. Seven-tesla magnetic resonance imaging of the nervus terminalis, olfactory tracts, and olfactory bulbs in COVID-19 patients with anosmia and hypogeusia. Frontiers In Radiology 2024, 4: 1322851. PMID: 39410969, PMCID: PMC11473298, DOI: 10.3389/fradi.2024.1322851.Peer-Reviewed Original ResearchCOVID-19 patientsOlfactory bulbOlfactory tractNervus terminalisT2 hyperintensityAngiotensin-converting enzyme-2Olfactory nerveHealthy controlsSARS-CoV-2White matter T2 hyperintensitiesBoard-certified neuroradiologistsPotential entry sitesExpression of angiotensin-converting enzyme-2Viral entry siteBrain volume lossCentral nervous systemMagnetic resonance imagingBrainstem involvementT2 hyperintensitiesAbsence of NTOlfactory epitheliumVolume lossT2 signalACE-2 receptorHypogeusiaInflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2
Martin-Lopez E, Brennan B, Mao T, Spence N, Meller S, Han K, Yahiaoui N, Wang C, Iwasaki A, Greer C. Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2. ENeuro 2024, 11: eneuro.0106-24.2024. PMID: 38834299, PMCID: PMC11185043, DOI: 10.1523/eneuro.0106-24.2024.Peer-Reviewed Original ResearchOlfactory bulbOlfactory epitheliumPiriform cortexOlfactory tractOlfactory systemSARS-CoV-2Projection neuronsMyelination defectsOlfactory sensory neuronsLateral olfactory tractLoss of olfactionRespiratory epithelial cellsLamina propria macrophagesSARS-CoV-2 infectionInfected SCDays of infectionIntegrity of myelinOlfactory dysfunctionInfected microgliaSensitive to infectionOlfactory deficitsSensory neuronsSustentacular cellsNasal cavityNeuronal conduction
2016
Axonal branching in lateral olfactory tract is promoted by Nogo signaling
Iketani M, Yokoyama T, Kurihara Y, Strittmatter SM, Goshima Y, Kawahara N, Takei K. Axonal branching in lateral olfactory tract is promoted by Nogo signaling. Scientific Reports 2016, 6: 39586. PMID: 28000762, PMCID: PMC5175167, DOI: 10.1038/srep39586.Peer-Reviewed Original ResearchConceptsLateral olfactory tractCultured OB neuronsOB neuronsCollateral branchesAxonal branchingOlfactory bulbOlfactory tractAxonal bundlesMajor projection neuronsReceptor 1 antagonistKnockdown of NogoCollateral formationProjection neuronsPrimary axonsNogo signalingMitral cellsMiceNeuronsExpression levelsAbnormal increaseTractNogoAntagonistAxons
1995
Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
Sucher N, Akbarian S, Chi C, Leclerc C, Awobuluyi M, Deitcher D, Wu M, Yuan J, Jones E, Lipton. Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain. Journal Of Neuroscience 1995, 15: 6509-6520. PMID: 7472413, PMCID: PMC6578025, DOI: 10.1523/jneurosci.15-10-06509.1995.Peer-Reviewed Original ResearchConceptsLateral olfactory tractLayer VOlfactory tractEntorhinal cortexRegional expression patternsPostnatal day 1NMDA receptor subunitsFunction of NMDARsGlutamate-activated channelsCA1 fieldInferior colliculiRodent CNSAdult brainLayers IIDay 1Triple combinationRodent brainAxonal outgrowthMRNA expressionReceptor subunitsBrain developmentNMDARSubiculumExpression patternsNeocortex
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