2024
Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis
Tang H, Du S, Niu Z, Zhang D, Tang Z, Chen H, Chen Z, Zhang M, Xu Y, Sun Y, Fu X, Norback D, Shao J, Zhao Z. Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis. BMC Microbiology 2024, 24: 505. PMID: 39614169, PMCID: PMC11606197, DOI: 10.1186/s12866-024-03668-9.Peer-Reviewed Original ResearchConceptsSpecies levelBacterial speciesAR childrenNasal cavityMethodsIn this case–control studyBody sitesControl groupBacterial diversityCase-control studyB-diversityOral swab samplesS. epidermidisStaphylococcus epidermidisStaphylococcus aureusBacterial characterizationMicrobesAllergic rhinitisSpeciesHealthy subjectsBackgroundAllergic rhinitisSwab samplesHealthy onesConclusionsOur studyMicroorganismsRhinitisImproved species assignments across the entire Anopheles genus using targeted sequencing
Boddé M, Makunin A, Teltscher F, Akorli J, Andoh N, Bei A, Chaumeau V, Desamours I, Ekpo U, Govella N, Kayondo J, Kobylinski K, Ngom E, Niang E, Okumu F, Omitola O, Ponlawat A, Rakotomanga M, Rasolonjatovoniaina M, Ayala D, Lawniczak M. Improved species assignments across the entire Anopheles genus using targeted sequencing. Frontiers In Genetics 2024, 15: 1456644. PMID: 39364005, PMCID: PMC11446804, DOI: 10.3389/fgene.2024.1456644.Peer-Reviewed Original ResearchSpecies assignmentSequence dataAmplicon sequencing dataSpecies population structureAccurate species identificationSamples to species levelNuclear lociPopulation structureAmplicon panelSpecies levelSpecies identificationTarget sequenceAnopheles genusGenusSpeciesAmpliconsComparison of samplesSequenceLociMosquitoesIncreased powerMadagascarControl measuresMetagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in mice
Chen H, Huang S, Zhao Y, Sun R, Wang J, Yao S, Huang J, Yu Z. Metagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in mice. Microbiology Spectrum 2024, 12: e03735-23. PMID: 38441977, PMCID: PMC10986500, DOI: 10.1128/spectrum.03735-23.Peer-Reviewed Original ResearchConceptsTaxonomic compositionGut microbiomeIntestinal microbiomeFunctional genesKEGG OrthologyMetagenomic analysisIntestinal microbiotaRegulatory mechanismsFunction of gut microbiomeComposition of gut microbiotaAbundance of functional genesMetagenomic sequencingGene functionGut microbiotaPotential regulatory mechanismSpecies levelIntervention of probioticsBacillus amyloliquefaciensMicrobiomeGenesMicrobiotaHost immune responseProbiotic interventionMetabolic reactionsSchistosoma japonicum</i>
2022
Microbial source tracking and antimicrobial resistance in one river system of a rural community in Bahia, Brazil
Moretto V, Bartley P, Ferreira V, Santos C, Silva L, Ponce-Terashima R, Blanton R, Reis M, Barbosa L. Microbial source tracking and antimicrobial resistance in one river system of a rural community in Bahia, Brazil. Brazilian Journal Of Biology 2022, 82: e231838. PMID: 33681894, DOI: 10.1590/1519-6984.231838.Peer-Reviewed Original ResearchConceptsHuman fecal contaminationMicrobial source trackingRiver systemsFecal contaminationSource trackingGram-negative bacteriaGut of humansSpecies levelVillage centerWater supplyRiverRural communitiesNegative bacteriaBacteriaAntimicrobial resistanceNatural resistanceResidual antibioticsAntibiotic bacteriaHuman sourcesContaminationFood animalsBahiaClasses of antibioticsCommunityUse of antibiotics
2020
An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint
Ramanan D, Sefik E, Galván-Peña S, Wu M, Yang L, Yang Z, Kostic A, Golovkina T, Kasper D, Mathis D, Benoist C. An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint. Cell 2020, 181: 1276-1290.e13. PMID: 32402238, PMCID: PMC7393667, DOI: 10.1016/j.cell.2020.04.030.Peer-Reviewed Original ResearchConceptsDouble-negative feedback loopTreg proportionImmunological modeGut immune responseGut commensalsControlling gut inflammationSpecies levelInbred mouse strainsMulti-generational transmissionTreg-dependent mannerCellular perturbationsRegulatory T cellsDisease susceptibilityNon-epigeneticMaternal transmissionInflammatory disease susceptibilityNon-geneticGut inflammationT cellsGenetic tuningMouse strainsImmune responseMultiple generationsImmune systemFeedback loop
2013
Upregulation of Cytoprotective Defense Mechanisms and Hypoxia-Responsive Proteins Imparts Tolerance to Acute Hypobaric Hypoxia
Jain K, Suryakumar G, Prasad R, Ganju L. Upregulation of Cytoprotective Defense Mechanisms and Hypoxia-Responsive Proteins Imparts Tolerance to Acute Hypobaric Hypoxia. High Altitude Medicine & Biology 2013, 14: 65-77. PMID: 23537263, DOI: 10.1089/ham.2012.1064.Peer-Reviewed Original ResearchMeSH KeywordsAltitudeAnimalsAtmospheric PressureCatalaseCreatine Kinase, MB FormDyspneaEndothelin-1ErythropoietinHeme Oxygenase-1HSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMaleMalondialdehydeMyocarditisMyocardiumNitric OxideOxidative StressProtein CarbonylationRatsRats, Sprague-DawleyReactive Oxygen SpeciesSuperoxide DismutaseTime FactorsUp-RegulationVascular Endothelial Growth Factor AConceptsEnvironmental stressHypoxia-responsive proteinsSubsequent oxidative damageReactive oxygen species levelsCellular machineryHypoxia-responsive moleculesResponsive genesOxygen species levelsSpecies levelDifferential expressionTolerant animalsDefense mechanismsOxidative damageCytoprotective chaperoneAntioxidant enzymesHypobaric hypoxiaHigh expressionHIF-1αProteinAdult Sprague-Dawley ratsExpressionMyocardial antioxidant enzymesAcute hypobaric hypoxiaSprague-Dawley ratsCK-MB activity
2011
Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development
Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V, Smith C. Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Experimental Hematology 2011, 40: 318-329.e2. PMID: 22198153, DOI: 10.1016/j.exphem.2011.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAldehydesAnimalsAnimals, CongenicB-LymphocytesBone Marrow TransplantationCell CountCell CycleCell LineageCells, CulturedColony-Forming Units AssayDNA DamageEnzyme InductionGene Expression RegulationHematopoiesisHematopoietic Stem CellsLymphopeniaMiceMice, Inbred C57BLMice, Knockoutp38 Mitogen-Activated Protein KinasesRadiation ChimeraReactive Oxygen SpeciesRetinal DehydrogenaseSignal TransductionConceptsB cell developmentHematopoietic stem cellsReactive oxygen speciesMitogen-activated protein kinase activityP38 mitogen-activated protein kinase activityProtein kinase activityExcess reactive oxygen speciesOxygen speciesReactive aldehydesStem cell numbersHematopoietic stem cell numbersReactive oxygen species levelsEarly B cellsNumber of HSCsHSC biologyCell cycle distributionKinase activityOxygen species levelsAldh1a1 deficiencyGene expressionSpecies levelIntracellular signalingAldehyde dehydrogenasesDNA damageCell cycling
2006
Molecular Phylogeny and Evolutionary Relationships Among Mosquitoes (Diptera: Culicidae) from the Northeastern United States Based on Small Subunit Ribosomal DNA (18S rDNA) Sequences
SHEPA J, ANDREADIS T, VOSSBRINCK C. Molecular Phylogeny and Evolutionary Relationships Among Mosquitoes (Diptera: Culicidae) from the Northeastern United States Based on Small Subunit Ribosomal DNA (18S rDNA) Sequences. Journal Of Medical Entomology 2006, 51 DOI: 10.1603/0022-2585(2006)43[443:mpaera]2.0.co;2.Peer-Reviewed Original ResearchSmall subunit ribosomal DNA sequencesRibosomal DNA sequencesSister groupMolecular phylogenyEvolutionary relationshipsDNA sequencesMonophyletic sister groupPhylogenetic dataPhylogenetic relationshipsDistinct cladesPhylogenetic studiesBasal cladeAnopheles MeigenMorphological charactersMosquito taxaRobineau-DesvoidyAedes MeigenSpecies levelGeneric levelMosquito speciesCulex L.PhylogenyCladeSpeciesOchlerotatusMolecular Phylogeny and Evolutionary Relationships Among Mosquitoes (Diptera: Culicidae) from the Northeastern United States Based on Small Subunit Ribosomal DNA (18S rDNA) Sequences
SHEPARD J, ANDREADIS T, VOSSBRINCK C. Molecular Phylogeny and Evolutionary Relationships Among Mosquitoes (Diptera: Culicidae) from the Northeastern United States Based on Small Subunit Ribosomal DNA (18S rDNA) Sequences. Journal Of Medical Entomology 2006, 43: 443-454. DOI: 10.1603/0022-2585%282006%2943%5b443%3ampaera%5d2.0.co%3b2.Peer-Reviewed Original ResearchSmall subunit ribosomal DNA sequencesRibosomal DNA sequencesSister groupMolecular phylogenyEvolutionary relationshipsDNA sequencesMonophyletic sister groupPhylogenetic dataPhylogenetic relationshipsDistinct cladesPhylogenetic studiesBasal cladeAnopheles MeigenMorphological charactersMosquito taxaRobineau-DesvoidyAedes MeigenSpecies levelGeneric levelMosquito speciesCulex L.PhylogenyCladeSpeciesOchlerotatus
1998
Genetic polymorphism of morphological and biochemical characters in a Natal, Brazil, population of Lutzomyia longipalpis (Diptera: Psychodidae).
Mukhopadhyay J, Ghosh K, Azevedo A, Rangel E, Munstermann L. Genetic polymorphism of morphological and biochemical characters in a Natal, Brazil, population of Lutzomyia longipalpis (Diptera: Psychodidae). Journal Of The American Mosquito Control Association 1998, 14: 277-82. PMID: 9813825.Peer-Reviewed Original ResearchConceptsGenetic isolationSpecies statusSpot phenotypeGenetic variationIsoenzyme lociMorphological phenotypesSpecies levelMorphological variationWeinberg expectationsField populationsBiochemical charactersLutzomyia longipalpisEastern BrazilPolymorphic charactersPhlebotomine sand fliesGenetic profileIntermediate formIsoenzyme frequenciesPhenotypeGenetic polymorphismsSand fliesNew WorldSpot patternsLociLongipalpis
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