2023
Pulmonary Function and Quality of Life in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study
Abdo M, Kunisaki K, Morris A, Stosor V, Chang D, D'Souza G, Crothers K, Abdel-Maksoud M, DiGuiseppi C, Brown T, Erlandson K, MaWhinney S. Pulmonary Function and Quality of Life in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study. AIDS Research And Human Retroviruses 2023, 39: 621-632. PMID: 37276144, PMCID: PMC10712368, DOI: 10.1089/aid.2023.0001.Peer-Reviewed Original ResearchConceptsPulmonary impairmentPulmonary functionOdds ratioMedian age 57 yearsMulticenter AIDS Cohort StudyGreater respiratory impairmentPulmonary function impairmentImpaired pulmonary functionAge 57 yearsHealth-related qualityLower physical HRQoLRespiratory health statusAIDS Cohort StudyCohort study dataQuality of lifeHRQoL scoresCohort studyLower HRQoLPhysical HRQoLHIV serostatusAdjusted analysisFunction impairmentRespiratory impairmentMmHg decreaseRespiratory health
2022
Pulmonary and physical function limitations in aging men with and without HIV from the Multicenter AIDS Cohort Study (MACS)
Abdo M, Kunisaki K, Morris A, Stosor V, Chang D, D'Souza G, Crothers K, Abdel-Maksoud M, DiGuiseppi C, Brown T, MaWhinney S, Erlandson K. Pulmonary and physical function limitations in aging men with and without HIV from the Multicenter AIDS Cohort Study (MACS). Annals Of Epidemiology 2022, 76: 50-60. PMID: 36244514, PMCID: PMC9881119, DOI: 10.1016/j.annepidem.2022.10.005.Peer-Reviewed Original ResearchConceptsMulticenter AIDS Cohort StudyWeak grip strengthGait speedGrip strengthPhysical functionPulmonary impairmentPulmonary functionGreater oddsSimilar gait speedSlow gait speedPhysical function limitationsAIDS Cohort StudyCohort study dataNormal FEVCohort studyMedian ageHIV serostatusHIVFunction limitationsFEVDlPhysical outcomesAgeFrailtyMen
2021
Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study
Abdo M, Kunisaki K, Stosor V, D'Souza G, Abdel-Maksoud M, Brown T, MaWhinney S, Erlandson K. Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study. Innovation In Aging 2021, 5: 612-612. PMCID: PMC8968408, DOI: 10.1093/geroni/igab046.2328.Peer-Reviewed Original ResearchHypertension careBlood pressureMulticenter AIDS Cohort StudyHypertension care cascadeControl of hypertensionElevated blood pressureMajor risk factorPhysical function limitationsAIDS Cohort StudyCause of deathLevel of diagnosisRetirement Longitudinal StudyPersons age 75Care cascadeCohort studyRisk factorsCardiovascular diseaseAge 75High riskFunction limitationsOlder personsHypertensionChina HealthModern medicationsOlder populationAssociations Between Meal Program Participation and Protein Intake in People Over 65 (NHANES 2013-2018)
Abdo M, Kunisaki K, Stosor V, D'Souza G, Abdel-Maksoud M, Brown T, MaWhinney S, Erlandson K. Associations Between Meal Program Participation and Protein Intake in People Over 65 (NHANES 2013-2018). Innovation In Aging 2021, 5: 613-614. PMCID: PMC8968276, DOI: 10.1093/geroni/igab046.2333.Peer-Reviewed Original ResearchWeak grip strengthGrip strengthHIV serostatusGait speedImpaired DLCONormal DLCOPulmonary functionPhysical functionMulticenter AIDS Cohort StudyPhysical function impairmentPulmonary function testsSlow gait speedAdjusted mixed-effects modelPhysical function limitationsAIDS Cohort StudyCohort study dataNormal FEV1Cohort studyCumulative smokingEffect of ageMedian ageFunction testsFunction impairmentEffect modificationSlow gaitEffect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study.
Abdo M, Langan SJ, MaWhinney S, Sun J, Lake JE, Palella FJ, Kingsley L, Brown TT, Erlandson KM. Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 86: 455-462. PMID: 33230030, PMCID: PMC8193908, DOI: 10.1097/qai.0000000000002579.Peer-Reviewed Original ResearchConceptsStatin usePhysical functionStatin usersHIV serostatusGait speedMulticenter AIDS Cohort StudyBaseline median ageGrip strength declineCardiovascular risk factorsGait speed declineAIDS Cohort StudyAge-associated changesYears of ageLong-term riskStatin therapyCohort studyMedian ageGrip strengthRisk factorsHIVStudy menSpeed declineAgeMenSerostatus
2019
Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study
Lu H, Surkan P, Irwin M, Treisman G, Breen E, Sacktor N, Stall R, Wolinsky S, Jacobson L, Abraham A. Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study. American Journal Of Epidemiology 2019, 188: 1994-2003. PMID: 31642472, PMCID: PMC6825834, DOI: 10.1093/aje/kwz190.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusMulticenter AIDS Cohort StudyAIDS Cohort StudyInflammatory processCohort studyHigher oddsDepressive symptomsSoluble tumor necrosis factor receptor 2Soluble interleukin-2 receptor αTumor necrosis factor receptor 2B-cell activating factorEpidemiological Studies Depression ScaleInterleukin-2 receptor αNecrosis factor receptor 2Relevant depression symptomsSoluble interleukin-6 receptorPathogenesis of depressionHigh-risk populationRisk of depressionFactor receptor 2Interleukin-6 receptorExploratory factor analysisHIV- menHIV- participantsInflammatory profile
1999
Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation.
Dean M, Jacobson L, McFarlane G, Margolick J, Jenkins F, Howard O, Dong H, Goedert J, Buchbinder S, Gomperts E, Vlahov D, Oppenheim J, O'Brien S, Carrington M. Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation. Cancer Research 1999, 59: 3561-4. PMID: 10446961.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsB-LymphocytesCase-Control StudiesChemokine CCL5Cohort StudiesGene FrequencyGenetic Predisposition to DiseaseHIV-1HumansLymphoma, AIDS-RelatedMalePoint MutationReceptors, CCR5RiskSarcoma, KaposiSequence DeletionTetradecanoylphorbol AcetateWhite PeopleConceptsNon-Hodgkin lymphomaB cellsAIDS lymphomasCCR5 geneRisk of NHLMulticenter AIDS Cohort StudyCCR5 ligand RANTEST-cell declineAIDS Cohort StudyCCR5-Delta32 alleleB-cell lymphomaCase-control analysisCCR5-Delta32 mutationChemokine receptor genesCCR5 chemokine receptor geneTime of infectionLigand RANTESTime AIDSCohort studyOpportunistic infectionsAIDS patientsCommon malignancyKaposi's sarcomaNHL casesProliferative response
1998
The Cost-effectiveness of Preventing AIDS-Related Opportunistic Infections
Freedberg KA, Scharfstein JA, Seage GR, Losina E, Weinstein MC, Craven DE, Paltiel AD. The Cost-effectiveness of Preventing AIDS-Related Opportunistic Infections. JAMA 1998, 279: 130-136. PMID: 9440663, DOI: 10.1001/jama.279.2.130.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAIDS-Related Opportunistic InfectionsAnti-Infective AgentsCD4 Lymphocyte CountChemopreventionCost-Benefit AnalysisCytomegalovirus InfectionsData CollectionHealth Care CostsHumansLife ExpectancyMarkov ChainsModels, TheoreticalMycobacterium avium-intracellulare InfectionMycosesPneumonia, PneumocystisQuality-Adjusted Life YearsRisk FactorsToxoplasmosisUnited StatesConceptsPneumocystis carinii pneumoniaCD4 cell countQuality-adjusted life expectancyOpportunistic infectionsCell countLife expectancyAdvanced human immunodeficiency virus diseaseAverage total lifetime costsHuman immunodeficiency virus (HIV) diseaseMycobacterium avium complex infectionMulticenter AIDS Cohort StudyIncremental cost-effectiveness ratioHIV patient careCost of prophylaxisCost-effective prophylaxisDirect medical costsAIDS Cohort StudyLifetime direct medical costsLong-term survivalCost-effectiveness ratioServices Utilization SurveyMarkov simulation modelTotal lifetime costsCytomegalovirus diseasePreventing AIDS
1994
Incidence Of Clinical Aids Conditions In A Cohort Of Homosexual Men With CD4+ Cell Counts <100/mm3
Bacellar H, Muñoz A, Hoover D, Phair J, Besley D, Kingsley L, Vermund S, Study F. Incidence Of Clinical Aids Conditions In A Cohort Of Homosexual Men With CD4+ Cell Counts <100/mm3. The Journal Of Infectious Diseases 1994, 170: 1284-1287. PMID: 7963728, DOI: 10.1093/infdis/170.5.1284.Peer-Reviewed Original ResearchConceptsIncidence rateHomosexual menCD4 cells/mm3P. carinii pneumonia prophylaxisHuman immunodeficiency virus type 1Multicenter AIDS Cohort StudyImmunodeficiency virus type 1Cells/mm3Use of antiretroviralsPneumocystis carinii pneumoniaAIDS Cohort StudyHealth care providersMycobacterium avium complexVirus type 1Cytomegalovirus diseasePneumonia prophylaxisCytomegalovirus retinitisAIDS illnessCohort studyOpportunistic infectionsAIDS conditionsCarinii pneumoniaClinical trialsKaposi's sarcomaCare providers
1993
Depressive Symptoms as Predictors of Medical Outcomes in HIV Infection
Lyketsos C, Hoover D, Guccione M, Senterfitt W, Dew M, Wesch J, VanRaden M, Treisman G, Morgenstern H, Saah A, Palenicek J, Armenian H, Farzadegan H, Graham N, Margolick J, McArthur J, Phair J, Chmiel J, Cohen B, O'Gorman M, Variakojis D, Wesch J, Wolinsky S, Detels R, Visscher B, Chen I, Dudley J, Fahey J, Giorgi J, Lee M, Martinez-Mara O, Miller E, Nishanian P, Taylor J, Zack J, Rinaldor C, Kingsley L, Becker J, Gupta P, Ho M, Muñoz A, Jacobson L, Beaty T, Galai N, Epstein L, Guccione M, Hoover D, Meinert C, Nelson K, Piantadosi S, Su S, Schrager L, Vermund S, Kaslow R, VanRaden M, Seminara D. Depressive Symptoms as Predictors of Medical Outcomes in HIV Infection. JAMA 1993, 270: 2563-2567. DOI: 10.1001/jama.1993.03510210049026.Peer-Reviewed Original ResearchHuman immunodeficiency virusCD4 countCohort studyHIV infectionDepressive symptomsMedical outcomesEight-year cohort studyHIV-seropositive homosexual menMulticenter AIDS Cohort StudyLow CD4 countEpidemiologic Studies Depression ScaleAssociation of depressionEight-year followWorse medical outcomesAIDS Cohort StudyHIV outcomesImmunodeficiency syndromeImmunodeficiency virusProphylactic treatmentEligible participantsWorse outcomesMore AIDSOutcome measuresHomosexual menSymptomsTrends in the Incidence of Outcomes Defining Acquired Immunodeficiency Syndrome (AIDS) in the Multicenter AIDS Cohort Study: 1985–1991
Muñoz A, Schrager L, Bacellar H, Speizer I, Vermund S, Detels R, Saah A, Kingsley L, Seminara D, Phair J. Trends in the Incidence of Outcomes Defining Acquired Immunodeficiency Syndrome (AIDS) in the Multicenter AIDS Cohort Study: 1985–1991. American Journal Of Epidemiology 1993, 137: 423-438. PMID: 8096356, DOI: 10.1093/oxfordjournals.aje.a116691.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAIDS-Related Opportunistic InfectionsCD4-Positive T-LymphocytesCohort StudiesCytomegalovirus InfectionsHerpes SimplexHIV SeropositivityHIV-1HumansIncidenceLeukocyte CountLymphomaMaleNervous System DiseasesPneumonia, PneumocystisProspective StudiesRegression AnalysisRisk FactorsSarcoma, KaposiUnited StatesConceptsAcquired Immunodeficiency SyndromeP. carinii pneumoniaCarinii pneumoniaProgressive immunosuppressionKaposi's sarcomaImmunodeficiency syndromeOpportunistic infectionsHerpes simplex virus infectionHuman immunodeficiency virus type 1Multicenter AIDS Cohort StudyImmunodeficiency virus type 1Use of chemoprophylaxisUse of prophylaxisIncidence of outcomesPneumocystis carinii pneumoniaSimplex virus infectionAIDS Cohort StudyVirus type 1Antiretroviral therapyCohort studyClinical outcomesInitial diagnosisSecondary diagnosisLower incidenceNeurologic disease
1992
Recent Scientific Contributions to Understanding HIV/AIDS from the Multicenter AIDS Cohort Study
Detels R, Phair J, Saah A, Rinaldo C, Murioz A, Kaslow R, Seminara D, Schrager L, Vermund S. Recent Scientific Contributions to Understanding HIV/AIDS from the Multicenter AIDS Cohort Study. Journal Of Epidemiology 1992, 2: 11. DOI: 10.2188/jea.2.2sup_11.Peer-Reviewed Original ResearchMulticenter AIDS Cohort StudyAIDS Cohort StudyCohort studyPublic healthPrincipal investigatorComprehensive cancer centerNational Cancer InstituteHIV/AIDSCancer CenterUniversity Medical SchoolCancer InstituteJohns Hopkins University SchoolInfectious diseasesJohns Hopkins SchoolPittsburgh Graduate SchoolNational InstituteUniversity SchoolHealthHygieneInvestigatorsUniversity of CaliforniaProject officersMedical schoolsAllergyAIDS
1991
Zidovudine use in AIDS-free HIV-1-seropositive homosexual men in the Multicenter AIDS Cohort Study (MACS), 1987-1989.
Graham NM, Zeger SL, Kuo V, Jacobson LP, Vermund SH, Phair JP, Detels R, Rinaldo CR, Saah AJ. Zidovudine use in AIDS-free HIV-1-seropositive homosexual men in the Multicenter AIDS Cohort Study (MACS), 1987-1989. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1991, 4: 267-76. PMID: 1671411.Peer-Reviewed Original ResearchConceptsHIV-1 seropositive homosexual menZidovudine useVisit 11Clinical variablesClinical trialsHomosexual menVisit 7Multicenter AIDS Cohort StudyLymphocytes/mm3Major clinical variablesClinical trial participationAIDS Cohort StudyClinical trial participantsSeropositive participantsZidovudine therapyCohort studyHigher treatment ratesLymphocyte levelsLymphocyte numbersNonclinical factorsAIDS patientsTrial participationSymptom statusOverall prevalenceOdds ratio
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