2023
Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD
Jiang K, Greenberg J, Abraham A, Xu Y, Schelling J, Feldman H, Schrauben S, Waikar S, Shlipak M, Wettersten N, Coca S, Vasan R, Gutierrez O, Ix J, Warady B, Kimmel P, Bonventre J, Parikh C, Mitsnefes M, Denburg M, Furth S, Ramachandran V, Schelling J, Denburg M, Furth S, Warady B, Bonventre J, Waikar S, Sabbisetti V, Coresh J, Grams M, Rebholz C, Abraham A, Parikh C, Coca S, Rhee E, Kimmel P, Kusek J, Rovin B, Shlipak M, Sarnak M, Gutiérrez O, Ix J, Dubin R, Hostetter T, Deo R, Feldman H, Xie D, Shou H, Ballard S, Whitehead K, Collins H, Greenberg J, Ganz P. Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD. Kidney360 2023, 4: 1039-1047. PMID: 37303083, PMCID: PMC10476681, DOI: 10.34067/kid.0000000000000183.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Left ventricular hypertrophyUrine KIM-1Injury molecule-1Chemoattractant protein-1Ventricular hypertrophyAlpha-1-microglobulinHigher plasmaLVH prevalenceHigh prevalenceMolecule-1Urine kidney injury molecule-1Urine monocyte chemoattractant protein-1Soluble urokinase-type plasminogen activator receptorTumor necrosis factor receptor 2Monocyte chemoattractant protein-1Kidney tubule healthNecrosis factor receptor 2Pathophysiology of LVHUrine MCP-1Multivariable-adjusted modelsMCP-1 concentrationsBody mass indexProtein 1Child Cohort Study
2020
Signaling through tumor necrosis receptor 2 induces stem cell marker in CD133+ regenerating tubular epithelial cells in acute cell-mediated rejection of human renal allografts
Bradley JR, Wang J, Bardsley V, Broecker V, Thiru S, Pober JS, Al-Lamki R. Signaling through tumor necrosis receptor 2 induces stem cell marker in CD133+ regenerating tubular epithelial cells in acute cell-mediated rejection of human renal allografts. American Journal Of Transplantation 2020, 20: 2380-2391. PMID: 32167668, DOI: 10.1111/ajt.15846.Peer-Reviewed Original Research
2019
Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study
Lu H, Surkan P, Irwin M, Treisman G, Breen E, Sacktor N, Stall R, Wolinsky S, Jacobson L, Abraham A. Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study. American Journal Of Epidemiology 2019, 188: 1994-2003. PMID: 31642472, PMCID: PMC6825834, DOI: 10.1093/aje/kwz190.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusMulticenter AIDS Cohort StudyAIDS Cohort StudyInflammatory processCohort studyHigher oddsDepressive symptomsSoluble tumor necrosis factor receptor 2Soluble interleukin-2 receptor αTumor necrosis factor receptor 2B-cell activating factorEpidemiological Studies Depression ScaleInterleukin-2 receptor αNecrosis factor receptor 2Relevant depression symptomsSoluble interleukin-6 receptorPathogenesis of depressionHigh-risk populationRisk of depressionFactor receptor 2Interleukin-6 receptorExploratory factor analysisHIV- menHIV- participantsInflammatory profile
2013
Functional Analyses of TNFR2 in Physiological and Pathological Retina AngiogenesisTNFR2 Mediates Retinal Angiogenesis
Wan T, Xu Z, Zhou HJ, Zhang H, Luo Y, Li Y, Min W. Functional Analyses of TNFR2 in Physiological and Pathological Retina AngiogenesisTNFR2 Mediates Retinal Angiogenesis. Investigative Ophthalmology & Visual Science 2013, 54: 211-221. PMID: 23188724, PMCID: PMC3544528, DOI: 10.1167/iovs.12-10364.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-2AnimalsAnimals, NewbornCell SurvivalDisease Models, AnimalEndothelium, VascularEpithelial CellsGene ExpressionHumansHypoxiaInfant, NewbornMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeovascularization, PathologicNF-kappa BOxygenProtein-Tyrosine KinasesReceptor, TIE-2Receptors, Tumor Necrosis Factor, Type IIRetinaRetinal NeovascularizationRetinopathy of PrematurityVascular Endothelial Growth Factor Receptor-2ConceptsTumor necrosis factor receptor 2Wild-type C57BL/6 miceTNFR2 deletionTNFR2-KOOIR modelOxygen-induced retinopathy modelNecrosis factor receptor 2Pathological neovascular tuftsRetinal vascular repairVascular ECsRetinal vascular developmentIschemia-induced revascularizationRetinal vasculature developmentFactor receptor 2Vascular endothelial cellsPreretinal neovascularizationVascular developmentC57BL/6 miceNeovascular tuftsKO miceNeonatal miceIsolectin stainingVascular repairBone marrow kinasePostnatal day
2004
Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2
Lainez B, Fernandez-Real J, Romero X, Esplugues E, Cañete J, Ricart W, Engel P. Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2. International Immunology 2004, 16: 169-177. PMID: 14688072, DOI: 10.1093/intimm/dxh014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlternative SplicingAnimalsArthritis, RheumatoidBase SequenceChlorocebus aethiopsCloning, MolecularCOS CellsEnzyme-Linked Immunosorbent AssayEtanerceptFemaleHumansImmunoglobulin GMaleMiddle AgedMolecular Sequence DataProtein IsoformsReceptors, Tumor Necrosis FactorSepsisTransfectionTumor Necrosis Factor-alphaConceptsAlternative splicingCell death inductionTNF-alpha-induced apoptosisExtracellular ectodomainMultiple inflammatory pathologiesCytoplasmic domainNovel isoformHuman TNFR2COS cellsExpression studiesDeath inductionCell typesTNF-alpha functionReceptors TNFR1SplicingExon 7Soluble formIsoformsBiological effectsBiological activityTumor necrosis factor receptor 2Pleiotropic cytokineNecrosis factor receptor 2Factor receptor 2TNFR2
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