2025
TblncRNA-23, a long non-coding RNA transcribed by RNA polymerase I, regulates developmental changes in Trypanosoma brucei
Galili-Kostin B, Rajan K, Ida Ashkenazi Y, Freedman A, Doniger T, Cohen-Chalamish S, Waldman Ben-Asher H, Unger R, Roditi I, Tschudi C, Michaeli S. TblncRNA-23, a long non-coding RNA transcribed by RNA polymerase I, regulates developmental changes in Trypanosoma brucei. Nature Communications 2025, 16: 3697. PMID: 40251171, PMCID: PMC12008373, DOI: 10.1038/s41467-025-58979-w.Peer-Reviewed Original ResearchConceptsProcyclic formsNon-coding RNAsLong non-coding RNAsPolycistronic transcription unitsRNA polymerase I.RNA polymerase IProtozoan parasite Trypanosoma bruceiRegulate gene expressionParasite Trypanosoma bruceiTsetse fly vectorComplex life cycleInsect midgutProcyclin genesSocial motilityLate procyclic formsRegulating developmental changesTranscription unitPolymerase I.Polymerase IBase pairsMammalian hostsTrypanosoma bruceiChanging abundanceInsect hostsTarget mRNAs
2023
Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces Plasmodium transmission
Chuang Y, Stone H, Abouneameh S, Tang X, Fikrig E. Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces Plasmodium transmission. MBio 2023, 15: e02257-23. PMID: 38078744, PMCID: PMC10790699, DOI: 10.1128/mbio.02257-23.Peer-Reviewed Original ResearchBlood mealComplex life cycleMosquito fitnessMammalian hostsMammalian adiponectinPathogen infectivityLipid transportersVertebrate hostsAdiponectin receptorsHematophagous arthropodsFemale mosquitoesPlasmodium transmissionLife cycleMosquitoesImportant lipid transporterPathwayHostInfectious agentsVector-borne infectious agentsArthropodsAdiponectinReceptorsInfectionTransportersMeal
2018
De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria
Redmond SN, MacInnis BM, Bopp S, Bei AK, Ndiaye D, Hartl DL, Wirth DF, Volkman SK, Neafsey DE. De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria. Molecular Biology And Evolution 2018, 35: 1678-1689. PMID: 29722884, PMCID: PMC5995194, DOI: 10.1093/molbev/msy059.Peer-Reviewed Original ResearchConceptsDe novo mutationsEvolutionary ratesSlow evolutionary rateNovo mutationsComplex life cycleSlow generation timeLow-complexity regionsGenomic regionsLarge genomesGenomic epidemiology approachReintroduction scenariosCombination of sequencingP. falciparumViral speciesMutation rateClonal lineagesGenomeMutation studiesLibrary preparationIdentical parasitesGeneration timeBacterial pathogensMalaria parasitesMutationsGenomic epidemiology
2017
Molecular mechanisms that mediate invasion and egress of malaria parasites from red blood cells
Alaganan A, Singh P, Chitnis C. Molecular mechanisms that mediate invasion and egress of malaria parasites from red blood cells. Current Opinion In Hematology 2017, 24: 208-214. PMID: 28306665, DOI: 10.1097/moh.0000000000000334.Peer-Reviewed Original ResearchConceptsMalaria parasitesMolecular mechanismsPerforin-like proteinComplex life cycleHost cell invasionDiverse host cellsCurrent understandingDevelopment of inhibitorsDifferent life cycle stagesFemale gametesTimely secretionKey effector moleculesRegulated mannerMolecular basisFemale gametocytesVesicular organellesMosquito midgutFemale anopheline mosquitoesProtein ligandsHost cellsLife cycle stagesCell invasionFunctional roleEffector moleculesParasite growth
2011
[Identification of mosquito-parasitic microsporidia, Amblyospora rugosa and Trichoctosporea pygopellita (Microsporidia: Amblysporidae), from Acanthocyclops venustus and Acanthocyclops reductus (Copepoda: Cyclopidae), based on small subunit rDNA analysis].
Simakova A, Luk'iantsev V, Vossbrink S, Andreadis T. [Identification of mosquito-parasitic microsporidia, Amblyospora rugosa and Trichoctosporea pygopellita (Microsporidia: Amblysporidae), from Acanthocyclops venustus and Acanthocyclops reductus (Copepoda: Cyclopidae), based on small subunit rDNA analysis]. Паразитология 2011, 45: 140-6. PMID: 21874847.Peer-Reviewed Original Research
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