2021
Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study
Yadav D, Whitcomb D, Tang G, Slivka A, Bellin M, Consortium N, AlKaade S, Amann S, Anderson M, Banks P, Conwell D, Brand R, Cote G, Romagnuolo J, Forsmark C, Gardner T, Gelrud A, Guda N, Lewis M, Muniraj T, Sandhu B, Sherman S, Singh V, Wilcox C. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study. Clinical Gastroenterology And Hepatology 2021, 21: 226-228.e1. PMID: 34793964, DOI: 10.1016/j.cgh.2021.11.011.Peer-Reviewed Original ResearchConceptsChronic pancreatitisCytokine-induced beta-cell dysfunctionPancreatogenic diabetes mellitusPrimary pathophysiologic defectType 3c diabetesSubset of patientsBeta-cell dysfunctionRecurrent AcuteGlucose intoleranceDiabetes mellitusPathophysiologic defectsFibrotic changesInsulin deficiencyCell dysfunctionExocrine pancreasPilot studyPancreatitisMellitusAcuteDiabetesInflammationPatientsDysfunctionInjuryPancreas
1996
Corrective gene transfer in the human skin disorder lamellar ichthyosis
Choate K, Medalie D, Morgan J, Khavari P. Corrective gene transfer in the human skin disorder lamellar ichthyosis. Nature Medicine 1996, 2: 1263-1267. PMID: 8898758, DOI: 10.1038/nm1196-1263.Peer-Reviewed Original ResearchConceptsLamellar ichthyosisImmunodeficient mouse xenograft modelPrimary pathophysiologic defectMouse xenograft modelAbnormal epidermal differentiationCorrective gene transferCutaneous gene deliveryPathophysiologic defectsLI patientsEpidermal differentiationFunctional abnormalitiesPotential future approachesImmunodeficient miceXenograft modelSkin diseasesCutaneous barrierDifferentiation marker filaggrinFunction measuresNormal skinEpidermal barrierPatient's skinPrimary keratinocytesPatientsSkinHuman skin
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