2024
GABAergic Interneuron Dysfunction in Neurodevelopmental Disorders: A New Role for the Transcription Factor MEF2C in Regulating Parvalbumin Interneuron Survival and Function
Gupta J. GABAergic Interneuron Dysfunction in Neurodevelopmental Disorders: A New Role for the Transcription Factor MEF2C in Regulating Parvalbumin Interneuron Survival and Function. Biological Psychiatry 2024, 96: e19-e20. PMID: 39415396, DOI: 10.1016/j.biopsych.2024.09.001.Peer-Reviewed Original ResearchGABAergic interneuron dysfunctionInterneuron survivalInterneuron dysfunctionTranscription factor MEF2CThe role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda C, Pandit S, Turrini S, Reilly J, Palmisano A, Sprugnoli G, Hampel H, Benussi A, Borroni B, Press D, Rotenberg A, El Fakhri G, Koch G, Rossi S, Santarnecchi E. The role of parvalbumin interneuron dysfunction across neurodegenerative dementias. Ageing Research Reviews 2024, 101: 102509. PMID: 39306248, DOI: 10.1016/j.arr.2024.102509.Peer-Reviewed Original ResearchInterneuron dysfunctionCortical hyperexcitabilityTherapeutic targetCortical excitation/inhibition balanceRhythm disruptionFast-spikingPV+ cellsBasket neuronsPotential therapeutic targetInhibitory interneuronsExcitation/inhibition balanceOscillatory disruptionsSymptom onsetNovel biomarkersHyperexcitabilityDysfunctionNeuronal deathOscillatory activityDementia with Lewy bodiesPathophysiological frameworkClinical symptom onsetFrontotemporal dementia
2018
Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain
Anderson NC, Van Zandt MA, Shrestha S, Lawrence DB, Gupta J, Chen CY, Harrsch FA, Boyi T, Dundes CE, Aaron G, Naegele JR, Grabel L. Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain. Stem Cell Research 2018, 33: 83-94. PMID: 30340090, DOI: 10.1016/j.scr.2018.10.007.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyInterneuron progenitorsHippocampal-dependent spatial memory deficitsMemory deficitsMorris water maze testEpileptic mouse brainMature firing patternMature GABAergic interneuronsWater maze testSpatial memory deficitsGABAergic interneuron dysfunctionHippocampus of rodentsInterneuron dysfunctionLobe epilepsySuppress seizuresGABAergic interneuronsMaze testSeizure suppressionMouse modelMouse brainFiring patternsSeizuresTransplantMiceStem cells
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