2025
The hidden burden: self-reported irritability in adolescent girls signals higher psychiatric risk
Vidal-Ribas P, Krebs G, Silver J, Tseng W, Ford T, Stringaris A. The hidden burden: self-reported irritability in adolescent girls signals higher psychiatric risk. BMC Public Health 2025, 25: 1832. PMID: 40389896, PMCID: PMC12087224, DOI: 10.1186/s12889-025-23076-6.Peer-Reviewed Original ResearchConceptsSelf-reported irritabilityPrevalence of irritabilityIrritable moodParent reportAssociations of irritabilityMental health of childrenLevels of irritabilityAssessment of irritabilityAdolescent femalesMental health problemsPediatric irritabilityPsychopathological symptomsTemper outburstsHealth of childrenPsychiatric disordersPsychiatric riskDevelopmental trajectoriesEmotional problemsSelf-ReportMoodMental healthAdolescent malesLongitudinally Designed StudyChildren Aged 5BackgroundMost research
2017
Antipsychotics for aggression in adults: A meta-analysis
van Schalkwyk GI, Beyer C, Johnson J, Deal M, Bloch MH. Antipsychotics for aggression in adults: A meta-analysis. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 81: 452-458. PMID: 28754408, DOI: 10.1016/j.pnpbp.2017.07.019.Peer-Reviewed Original ResearchConceptsTreatment of aggressionAntipsychotic medicationNon-pharmacologic interventionsEffect sizeChoice of agentSignificant dose effectSignificant morbidityCochrane LibraryAntipsychotic agentsDopamine antagonistsPsychiatric illnessIrritable moodMultiple diagnosesClinical decisionAntipsychoticsSpecific agentsSearch termsSmall effect sizesDiagnosisDose effectMedicationsSymptom dimensionsAggressive behaviorTreatmentAdults
2015
Low-Dose Quetiapine Induced or Worsened Mania in the Context of Possible Undertreatment
Millard HY, Wilson BA, Noordsy DL. Low-Dose Quetiapine Induced or Worsened Mania in the Context of Possible Undertreatment. The Journal Of The American Board Of Family Medicine 2015, 28: 154-158. PMID: 25567837, DOI: 10.3122/jabfm.2015.01.140105.Peer-Reviewed Educational MaterialsConceptsLow-dose quetiapineCase reportManic symptomsLow dosesDrug-naïve patientsD2 receptor antagonismQuality of lifePossible undertreatmentAcute maniaReceptor blockadeAtypical antipsychoticsBipolar depressionReceptor antagonismPsychotic featuresLifetime prevalenceIrritable moodBipolar disorderMental illnessQuetiapineDopamine concentrationsManiaPotential inductionSymptomsWorseningDoses
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