2023
Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium
Bhat S, Malla A, Oddi V, Sen J, Bhandari R. Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research 2023, 1871: 119596. PMID: 37742721, DOI: 10.1016/j.bbamcr.2023.119596.Peer-Reviewed Original ResearchConceptsBlood-testis barrierSeminiferous epitheliumBlood-testis barrier disruptionMouse seminiferous epitheliumCell adhesionGerm cell adhesionActin-based cytoskeletonInositol hexakisphosphate kinase 1Inositol hexakisphosphate kinasesGerm cell lossDownregulation of transcriptsMammalian testisKnockout miceRound spermatidsSertoli cellsSubcellular mislocalizationCofilin dephosphorylationIntegrin signalingMouse testisTight junction protein claudin-3Transcriptional misregulationGap junction protein connexinCell junction integrityIP6K1Junction protein connexin
2017
IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids
Malla A, Bhandari R. IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids. Journal Of Cell Science 2017, 130: 2854-2866. PMID: 28743739, DOI: 10.1242/jcs.204966.Peer-Reviewed Original ResearchConceptsRound spermatidsTemporal regulationMale germ cell differentiationDeletion of IP6K1Associated First Person interviewGerm cell differentiationRNA-binding proteinsInositol hexakisphosphate kinasesFirst Person interviewRegulate several physiological processesSomatic histonesSpermatid differentiationSpermatid elongationMouse testisPachytene spermatocytesMouse spermatidsChromatoid bodyChromatin componentsPRM2 expressionTranslational derepressionSpermatidsAberrant localisationIP6K1Body formationPremature expression
2016
The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia
Ozturk S, Sozen B, Uysal F, Bassorgun I, Usta M, Akkoyunlu G, Demir N. The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia. Journal Of Assisted Reproduction And Genetics 2016, 33: 335-348. PMID: 26843391, PMCID: PMC4785164, DOI: 10.1007/s10815-016-0654-z.Peer-Reviewed Original ResearchConceptsPoly(A)-binding proteinNon-obstructive azoospermiaPoly(A)-binding protein geneSertoli cell-only syndromeTesticular biopsy samplesRound spermatidsPABP expressionExpression levelsIsolated spermatocytesTranslational controlProtein geneInfertile menPABPC1Male infertilitySpermatocytesPABPC3MRNA expressionArrest groupEPABSco groupBiopsy samplesMolecular backgroundProteinAzoospermiaEvaluate expression levels
2012
Epab and Pabpc1 Are Differentially Expressed During Male Germ Cell Development
Ozturk S, Guzeloglu-Kayisli O, Demir N, Sozen B, Ilbay O, Lalioti MD, Seli E. Epab and Pabpc1 Are Differentially Expressed During Male Germ Cell Development. Reproductive Sciences 2012, 19: 911-922. PMID: 22814100, PMCID: PMC4046314, DOI: 10.1177/1933719112446086.Peer-Reviewed Original ResearchConceptsRound spermatidsGene expressionMale germ cell developmentGerm cell developmentPABPC1 expressionTranslational regulationCytoplasmic polyadenylationPosttranscriptional mechanismsPABPC1Key proteinsCell developmentEPABSpatial expressionMature testesMouse testisMessenger RNASpermatogenic cellsTail lengthProteinSpermatocytesExpressionSpermatogoniaTestisEarly postnatal lifePolyadenylation
2011
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse
Beyret E, Lin H. Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Developmental Biology 2011, 355: 215-226. PMID: 21539824, PMCID: PMC3443393, DOI: 10.1016/j.ydbio.2011.04.021.Peer-Reviewed Original ResearchConceptsPIWI proteinsXY bodyMouse testisAdult mouse testisEarly round spermatidsSex chromosomesGenomic sequencesPiRNAsChromatoid bodyCytological characterizationPachytene stageGerm cellsPhenotypic analysisAdult testisRound spermatidsProteinMeiosisSpermatogenesisCytoplasmDense bodiesSpermatocytesTestisPiRNAChromosomesTransposon
2006
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis
Grivna ST, Pyhtila B, Lin H. MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 13415-13420. PMID: 16938833, PMCID: PMC1569178, DOI: 10.1073/pnas.0605506103.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsSmall RNAsTranslational machineryMRNA cap-binding complexArgonaute family proteinsCap-binding complexPIWI family membersPresence of DicerRound spermatidsSubset of miRNAsCytosolic ribonucleoproteinTranslational repressionGene regulationFamily proteinsSubfamily proteinsCytoplasmic proteinsTarget mRNAsMIWIPosttranscriptional levelPolysomal fractionsPolysome fractionsMature spermGene expressionImportant regulatorSpermiogenesisInterplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells
Kotaja N, Lin H, Parvinen M, Sassone-Corsi P. Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. Journal Of Cell Science 2006, 119: 2819-2825. PMID: 16787948, DOI: 10.1242/jcs.03022.Peer-Reviewed Original ResearchConceptsChromatoid bodyGerm cellsPost-transcriptional regulationRound spermatidsTestis-specific memberMale germ cellsHaploid germ cellsArgonaute familyKinesin KIF17bRNA metabolismNucleocytoplasmic transportTranscriptional coactivatorKIF17bMIWIFunctional interplayNuclear envelopeGene expressionMolecular mechanismsEssential roleRNASpermatidsPotential mechanismsCellsCoactivatorNew light
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