2024
Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics
Gordon J, Phizicky D, Schärfen L, Brown C, Escayola D, Kanyo J, Lam T, Simon M, Neugebauer K. Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics. Nucleic Acids Research 2024, 52: 9886-9903. PMID: 38943343, PMCID: PMC11381358, DOI: 10.1093/nar/gkae562.Peer-Reviewed Original ResearchPoly(A)-binding proteinTranscriptome dynamicsNuclear poly(A) binding proteinPoly(A) binding proteinMode of gene regulationFunctional consequences of phosphorylationLong-read sequencingIncreased mRNA turnoverNucleo-cytoplasmic exportConsequences of phosphorylationRegulation of poly(ACohort of mRNAsGene expression programsMRNA biogenesisCytoplasmic mixingMRNA turnoverGene regulationShorter poly(ARNA stabilityMitotic kinasesPoly(ACell cycleMRNA synthesisIncreased transcriptionBinding protein
2016
The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia
Ozturk S, Sozen B, Uysal F, Bassorgun I, Usta M, Akkoyunlu G, Demir N. The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia. Journal Of Assisted Reproduction And Genetics 2016, 33: 335-348. PMID: 26843391, PMCID: PMC4785164, DOI: 10.1007/s10815-016-0654-z.Peer-Reviewed Original ResearchConceptsPoly(A)-binding proteinNon-obstructive azoospermiaPoly(A)-binding protein geneSertoli cell-only syndromeTesticular biopsy samplesRound spermatidsPABP expressionExpression levelsIsolated spermatocytesTranslational controlProtein geneInfertile menPABPC1Male infertilitySpermatocytesPABPC3MRNA expressionArrest groupEPABSco groupBiopsy samplesMolecular backgroundProteinAzoospermiaEvaluate expression levels
2014
Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos
Ozturk S, Yaba-Ucar A, Sozen B, Mutlu D, Demir N. Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos. Reproduction Fertility And Development 2014, 28: 375-383. PMID: 25034140, DOI: 10.1071/rd14106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlastocystCells, CulturedChorionic GonadotropinDose-Response Relationship, DrugEmbryo Culture TechniquesFemaleFertility Agents, FemaleGene Expression Regulation, DevelopmentalGonadotropins, EquineMice, Inbred BALB COocytesOvulation InductionPoly(A)-Binding Protein IPoly(A)-Binding ProteinsSuperovulationTime FactorsConceptsEmbryonic poly(A)-binding proteinPregnant mare serum gonadotropinHuman chorionic gonadotrophinEarly embryo developmentAssisted Reproductive TechnologyMII oocytesFemale miceAdministered to female miceGerminal vesicleOocyte maturationEmbryo developmentIncreased postimplantation lossDose of gonadotropinsCycling female miceDecreased implantation rateQuality of oocytesImpaired oocyte maturationGene expressionExperimental animal studiesEffects of superovulationReverse transcription-polymerase chain reactionPoly(A)-binding proteinPotential risk factorsTranscription-polymerase chain reactionImplantation rate
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply