2021
Physiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylation
Li N, Kang H, Peng Z, Wang H, Weng S, Zeng X. Physiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylation. Ecotoxicology And Environmental Safety 2021, 221: 112418. PMID: 34146982, DOI: 10.1016/j.ecoenv.2021.112418.Peer-Reviewed Original ResearchConceptsHuman sperm viabilityHuman sperm functionHuman spermExposure of BPASperm functionProgesterone-induced acrosome reactionProtein tyrosine phosphorylationProtein tyrosine phosphorylation levelsAcrosome reactionMale infertilityHealthy peopleMouse sperm motilitySperm viabilityCalcium signalingPhosphorylation levelsTyrosine phosphorylation levelsBisphenol ASperm motilityProgressive motilityHyperactivationMotilityDetectable concentrationRemarkable declineTyrosine phosphorylationPlastic monomers
2017
Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases
Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA. Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases. ACS Central Science 2017, 3: 1322-1328. PMID: 29296673, PMCID: PMC5746864, DOI: 10.1021/acscentsci.7b00486.Peer-Reviewed Original ResearchStriatal-enriched protein tyrosine phosphataseProtein tyrosineTyrosine phosphatasePhosphatase inhibitorProtein tyrosine phosphataseProtein tyrosine phosphorylation levelsActive site cysteineProtein tyrosine phosphorylationTyrosine phosphorylation levelsHuman PTPsSite cysteinePTP targetsTyrosine phosphorylationRepresentative cysteine proteaseCysteine proteasesHuman diseasesCellular activitiesPhosphorylation levelsVirulence factorsEssential roleSelective mechanismIntracellular GSH concentrationSelective active sitesNeurodegenerative diseasesPTP
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