2024
Epidemiology, treatment and outcomes of gastroenteropancreatic neuroendocrine neoplasms
Uhlig J, Nie J, Gibson J, Cecchini M, Stein S, Lacy J, Kunz P, Kim H. Epidemiology, treatment and outcomes of gastroenteropancreatic neuroendocrine neoplasms. Scientific Reports 2024, 14: 30536. PMID: 39690170, PMCID: PMC11652651, DOI: 10.1038/s41598-024-81518-4.Peer-Reviewed Original ResearchConceptsGEP-NEN patientsGastroenteropancreatic neuroendocrine neoplasmsOverall survivalGEP-NENsTreatment patternsSystemic therapyNeuroendocrine neoplasmsAssociated with improved survivalLow-grade diseaseNational Cancer DatabaseLonger overall survivalSite-specific incidenceDisease specific factorsG3 NENSurgical resectionCancer DatabaseImproved survivalLow-stageCox regressionImprove outcomesPatientsIncidence increasesInternational guidelinesInvestigate incidenceSurvival
2020
A Consensus-Developed Morphological Re-Evaluation of 196 High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms and Its Clinical Correlations
Elvebakken H, Perren A, Scoazec J, Tang L, Federspiel B, Klimstra D, Vestermark L, Ali A, Zlobec I, Myklebust T, Hjortland G, Langer S, Gronbaek H, Knigge U, Janson E, Sorbye H. A Consensus-Developed Morphological Re-Evaluation of 196 High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms and Its Clinical Correlations. Neuroendocrinology 2020, 111: 883-894. PMID: 33002892, DOI: 10.1159/000511905.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumor G3High-grade gastroenteropancreatic neuroendocrine neoplasmsGastroenteropancreatic neuroendocrine neoplasmsNeuroendocrine tumorsKi-67GEP-NENsNeuroendocrine neoplasmsHigh-grade GEP-NENMedian progression-free survivalGEP-NEN patientsMedian overall survivalProgression-free survivalFirst-line chemotherapyResponse to chemotherapyMorphological criteriaOrganoid growth patternKi-67 <Proliferation rateMetastatic diseaseOverall survivalPrognostic significanceDesmoplastic stromaLonger survivalTumor cellsClinical correlates
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