2021
Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents
Lévy R, Langlais D, Béziat V, Rapaport F, Rao G, Lazarov T, Bourgey M, Zhou Y, Briand C, Moriya K, Ailal F, Avery D, Markle J, Lim A, Ogishi M, Yang R, Pelham S, Emam M, Migaud M, Deswarte C, Habib T, Saraiva L, Moussa E, Guennoun A, Boisson B, Belkaya S, Martinez-Barricarte R, Rosain J, Belkadi A, Breton S, Payne K, Benhsaien I, Plebani A, Lougaris V, Di Santo J, Neven B, Abel L, S. C, Bousfiha A, Marr N, Bustamante J, Liu K, Gros P, Geissmann F, Tangye S, Casanova J, Puel A. Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents. Journal Of Clinical Investigation 2021, 131: e150143. PMID: 34623332, PMCID: PMC8409595, DOI: 10.1172/jci150143.Peer-Reviewed Original ResearchConceptsCD4+ T cellsMemory CD4+ T cellsC-Rel deficiencyT cellsMyeloid cellsLymphoid cellsB cellsC-RelMultiple infectious agentsNaive CD4+ T cellsCD8+ T cellsAntigen-presenting cell functionConventional DC1sFrequency of NKMemory B cellsNaive T cellsNaive B cellsFunctional deficitsReduced IL-2 productionProduction of Th1Infectious agentsIL-23 productionIL-2 productionInduction of CD86 expressionB cell survival
2020
The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling
Reed JC, Preston-Hurlburt P, Philbrick W, Betancur G, Korah M, Lucas C, Herold KC. The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling. PLOS ONE 2020, 15: e0236921. PMID: 32986722, PMCID: PMC7521722, DOI: 10.1371/journal.pone.0236921.Peer-Reviewed Original ResearchConceptsT cellsAdvanced glycation endproductsRAGE expressionGlycation endproductsType 1 diabetes mellitusLess IL-2T cell reactivityT-cell phenotypeHealthy control subjectsIL-2 productionT cell receptorPhosphorylation of ZAP70Human T cellsDiabetes mellitusAutoimmune diseasesJurkat cellsCell reactivityControl subjectsInflammatory productsIL-2Primary CD4T cell signalingCell receptorPatientsCell phenotype
2014
Human IL-7Rα low memory CD8+ T cells are clonal anergic cells being reversed by exogenous IL-2 (IRC10P.469)
Sim J, Cho B, Lee S, Ko Y, Seol M, Kim J, Oh K, Lee D, Kang I, Choi K, Kim H. Human IL-7Rα low memory CD8+ T cells are clonal anergic cells being reversed by exogenous IL-2 (IRC10P.469). The Journal Of Immunology 2014, 192: 192.7-192.7. DOI: 10.4049/jimmunol.192.supp.192.7.Peer-Reviewed Original Research
2010
Human IL-7Rαlow memory CD8+ T cells have defect in the calcium signaling pathway in response to TCR triggering, leading to impaired IL-2 production and proliferation. (132.34)
Lee H, Yu M, Lee D, Kang J, Hwang Y, Lee W, Kang I, Kim H. Human IL-7Rαlow memory CD8+ T cells have defect in the calcium signaling pathway in response to TCR triggering, leading to impaired IL-2 production and proliferation. (132.34). The Journal Of Immunology 2010, 184: 132.34-132.34. DOI: 10.4049/jimmunol.184.supp.132.34.Peer-Reviewed Original ResearchIL-2 productionMemory CD8T cellsCytokine productionIL-7Effector cytokine productionT cell subsetsAnergic T cellsPMA/ionomycin treatmentAnti-CD3 AbTCR triggeringEffector cytokinesAnergic phenotypeCell subsetsHuman CD8IL-2CD8Calcium fluxTCR stimulationIonomycin treatmentCell survival responseMAPK pathwayCellular characteristicsProliferationCells
2009
Expression of Diabetes-Associated Genes by Dendritic Cells and CD4 T Cells Drives the Loss of Tolerance in Nonobese Diabetic Mice
Hamilton-Williams EE, Martinez X, Clark J, Howlett S, Hunter KM, Rainbow DB, Wen L, Shlomchik MJ, Katz JD, Beilhack GF, Wicker LS, Sherman LA. Expression of Diabetes-Associated Genes by Dendritic Cells and CD4 T Cells Drives the Loss of Tolerance in Nonobese Diabetic Mice. The Journal Of Immunology 2009, 183: 1533-1541. PMID: 19592648, PMCID: PMC2733871, DOI: 10.4049/jimmunol.0900428.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsDendritic cellsNOD miceProtective allelesCD4 T-cell expressionTolerance defectsImmune tolerance resultsPancreatic lymph nodesCD8 T cellsNonobese diabetic (NOD) miceCD4 T cellsT cell expressionLoss of toleranceIL-2 productionDiabetes 3Lymph nodesDiabetic miceIslet AgsNOD alleleCell expressionMiceSpontaneous developmentIdd3Tolerance results
2006
Cutting Edge: CD4 Is the Receptor for the Tick Saliva Immunosuppressor, Salp15
Garg R, Juncadella IJ, Ramamoorthi N, Ashish, Ananthanarayanan SK, Thomas V, Rincón M, Krueger JK, Fikrig E, Yengo CM, Anguita J. Cutting Edge: CD4 Is the Receptor for the Tick Saliva Immunosuppressor, Salp15. The Journal Of Immunology 2006, 177: 6579-6583. PMID: 17082567, PMCID: PMC4302324, DOI: 10.4049/jimmunol.177.10.6579.Peer-Reviewed Original ResearchConceptsDownstream effector proteinsSrc kinase LckC-terminal residuesLipid raft reorganizationEffector proteinsKinase LckTyrosine phosphorylationMolecular basisExtracellular domainEarly stepsSalp15T cell activationSalivary proteinsCD4 coreceptorProteinCalcium fluxCell activationT cellsCellsLckRepressionPhosphorylationIL-2 productionResiduesCoreceptorIL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells
Nomura LE, Emu B, Hoh R, Haaland P, Deeks SG, Martin JN, McCune JM, Nixon DF, Maecker HT. IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells. AIDS Research And Therapy 2006, 3: 18. PMID: 16859558, PMCID: PMC1562434, DOI: 10.1186/1742-6405-3-18.Peer-Reviewed Original ResearchHIV-specific CD8HIV-positive subjectsHIV-specific T cellsCMV-specific T cellsEffector cell differentiationT cellsIL-2Effector cellsIL-2 production correlatesMemory/effector phenotypeTerminal effector cellsAntigen-specific CD8Cytokine flow cytometryHIV-negative subjectsIL-2 productionCD27-CD28HIV-negativeCytokine profileProgressive diseaseEffector phenotypeHIV-specificEffector differentiationCD8Cell differentiationCell frequency
2005
Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation
Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J. Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation. The Journal Of Immunology 2005, 174: 5100-5109. PMID: 15814741, DOI: 10.4049/jimmunol.174.8.5100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoimmunityCalcium SignalingCD4-Positive T-LymphocytesCell ProliferationColumbidaeCytochromes cDendritic Cellsfas ReceptorGenes, DominantInterleukin-2Lupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, Inbred StrainsMice, KnockoutMice, TransgenicPhenotypeReceptor-CD3 Complex, Antigen, T-CellReceptors, Antigen, T-CellSignal TransductionConceptsNaive CD4T cellsSelf-AgAutoreactive T cell activationMRL T cellsT cell toleranceF1 T cellsProximal defectsAnti-CD3 stimulationClass II MHCIL-2 productionT cell activationWild-type CD4Pigeon cytochrome cCell calcium signalingDendritic cellsControl miceMurine lupusObserved hyperactivityII MHCMRL miceIntracellular calciumLow thresholdPeptide AgCD4
2001
Phenotypic and Functional Analysis of Tumor-Infiltrating Lymphocytes Compared with Tumor-Associated Lymphocytes from Ascitic Fluid and Peripheral Blood Lymphocytes in Patients with Advanced Ovarian Cancer
Santin AD, Hermonat PL, Ravaggi A, Bellone S, Roman JJ, Smith CV, Pecorelli S, Radominska-Pandya A, Cannon MJ, Parham GP. Phenotypic and Functional Analysis of Tumor-Infiltrating Lymphocytes Compared with Tumor-Associated Lymphocytes from Ascitic Fluid and Peripheral Blood Lymphocytes in Patients with Advanced Ovarian Cancer. Gynecologic And Obstetric Investigation 2001, 51: 254-261. PMID: 11408737, DOI: 10.1159/000058060.Peer-Reviewed Original ResearchConceptsTumor-associated lymphocytesTumor-infiltrating lymphocytesPeripheral blood lymphocytesAdvanced ovarian cancerType 1 cytokinesT cellsBlood lymphocytesOvarian cancerAscitic fluidAntigen-experienced T lymphocytesActivation markers HLA-DREarly activation markers CD25Markers HLA-DRType 2 cytokinesActivation markers CD25Major leukocyte populationsIL-2 pathwayIL-2 receptorFunction of lymphocytesIL-2 productionLow surface expressionLymphocyte subsetsHigher proportionHLA-DRActivation markers
1999
Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone.
Milner J, Kent S, Ashley T, Wilson S, Strominger J, Hafler D. Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. The Journal Of Immunology 1999, 163: 2522-9. PMID: 10452989, DOI: 10.4049/jimmunol.163.5.2522.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAntibodies, BlockingAntibodies, MonoclonalAntigens, CD1Antigens, CD1dAntigens, Differentiation, B-LymphocyteApoptosisAutocrine CommunicationCD3 ComplexCD4-Positive T-LymphocytesClone CellsDexamethasoneDose-Response Relationship, Immunologicfas ReceptorHistocompatibility Antigens Class IIHumansImmunosuppressive AgentsInterleukin-2Lymphocyte ActivationReceptors, Antigen, T-Cell, alpha-betaSignal TransductionT-Lymphocyte SubsetsConceptsActivation-induced cell deathT cell clonesT cellsTCR signal strengthCell clonesAutocrine IL-2 productionNK T cellsT cell responsesT cell subsetsInhibition of CD4Anti-CD3 stimulationT cell proliferationEffect of dexamethasoneMHC class IIIL-2 productionPresence of dexamethasoneExogenous corticosteroidsCell subsetsImmunomodulatory consequencesDexamethasone treatmentImmune responseCD4High dosesLow dosesCell responses
1996
Selected P. falciparum specific immune responses are maintained in AIDS adults in Burkina Faso
MIGOT F, OUEDRAOGO J, DIALLO J, ZAMPAN H, DUBOIS B, SCOTT‐FINNIGAN T, .SANOU P, DELORON P. Selected P. falciparum specific immune responses are maintained in AIDS adults in Burkina Faso. Parasite Immunology 1996, 18: 333-339. PMID: 9229386, DOI: 10.1046/j.1365-3024.1996.d01-116.x.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAnimalsAntigens, ProtozoanBurkina FasoCase-Control StudiesCD4 Lymphocyte CountCD4-Positive T-LymphocytesCytokinesHIV-1HumansIn Vitro TechniquesInterferon-gammaInterleukin-2Interleukin-4Lymphocyte ActivationMalaria, FalciparumMiddle AgedPlasmodium falciparumConceptsImmune responseSchizont extractCytokine productionHIV-1Healthy subjectsHIV-1-positive subjectsSpecific human immune responsesCrude schizont extractNegative healthy subjectsPlasmodium falciparum malariaHIV-1 infectionIL-4 productionSpecific immune responseHuman immune responseWhole blood culturesIL-2 productionPresence of PHAMerozoite surface proteinAIDS adultsLymphocyte subsetsFalciparum malariaClinical AIDSAIDS patientsPositive subjectsMalarial antigensHTLV-I-induced T-cell activation.
Buckle GJ, Hafler DA, Höllsberg P. HTLV-I-induced T-cell activation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1996, 13 Suppl 1: s107-13. PMID: 8797712, DOI: 10.1097/00042560-199600001-00018.Peer-Reviewed Original ResearchConceptsT cell activationT cellsUninfected T cellsT cell interactionsMyelopathy/tropical spastic paraparesisHuman T-cell lymphotropic virus type ILymphotropic virus type ITropical spastic paraparesisInfected T cellsT cell clonesIL-2 productionInterleukin-2 productionVirus type ISpastic paraparesisSpontaneous proliferationCD28 pathwayGeneralized activationCostimulatory signalsImmune systemSeparate mechanismsHTLVProlonged stateType IActivationCells
1995
Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro.
Murray AG, Libby P, Pober JS. Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro. The Journal Of Immunology 1995, 154: 151-61. PMID: 7995934, DOI: 10.4049/jimmunol.154.1.151.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsT cell proliferationClass II moleculesHuman vascular smooth muscle cellsMHC class II moleculesT cellsIL-2 productionSmooth muscle cellsEndothelial cellsCell proliferationFunctional MHC class II moleculesII-positive endothelial cellsIL-2-producing cellsMuscle cellsPre-activated T cellsAllogeneic endothelial cellsNitric oxide synthesisInhibition of proliferationVSMC-conditioned mediumAllogeneic CD4CD25 expressionInhibits CD4Immunologic functionVSMC expressionSaphenous vein
1993
Costimulation of peripheral blood T cell activation by human endothelial cells. Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1.
Hughes CC, Pober JS. Costimulation of peripheral blood T cell activation by human endothelial cells. Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1. The Journal Of Immunology 1993, 150: 3148-60. PMID: 8468462, DOI: 10.4049/jimmunol.150.8.3148.Peer-Reviewed Original ResearchConceptsC-fos mRNAIL-2 transcriptionNuclear factorT cellsTranscription factor AP-1PHA activationPeripheral blood T cell activationAP-1Blood T cell activationFactor AP-1C-fosC-JunIL-2 productionHuman umbilical vein ECT cell activationIL-2 mRNAC-Fos proteinEC costimulationEndothelial cells (EC) actAllograft rejectionHuman endothelial cellsIL-2 regulationCostimulatory signalsCell activationKey molecular mechanismsNitric Oxide Modulates Lymphocyte Proliferation But Not Secretion of IL-2
Huot AE, Moore AL, Roberts JD, Hacker MP. Nitric Oxide Modulates Lymphocyte Proliferation But Not Secretion of IL-2. Immunological Investigations 1993, 22: 319-327. PMID: 7689536, DOI: 10.3109/08820139309063411.Peer-Reviewed Original ResearchConceptsLymphocyte proliferationBAL cellsIL-2Nitric oxideNO synthase inhibitor NG-monomethylSynthase inhibitor NG-monomethylExcess IL-2Bronchoalveolar lavage cellsInhibitor NG-monomethylCytokines IL-2Time of sacrificeIL-2 productionInterleukin-2 productionModulate lymphocyte proliferationSource of NOIL-2-dependent CTLL-2 cellsLavage cellsNG-monomethylCytokine releaseIntratracheal doseCTLL-2 cellsL-arginineLymphocyte growthMarked inhibitionNO inhibits
1990
The Endothelial Cell as a Regulator of T‐Cell Function
Hughes. C, Savage C, Pober JS. The Endothelial Cell as a Regulator of T‐Cell Function. Immunological Reviews 1990, 117: 85-102. PMID: 2258192, DOI: 10.1111/j.1600-065x.1990.tb00568.x.Peer-Reviewed Original ResearchConceptsIL-2 productionT cell IL-2 productionT cellsClass II moleculesLFA-3Peripheral blood mononuclear cellsAntigen-presenting capacityMemory T cellsMHC class II moleculesBlood mononuclear cellsNon-immune cell typesT cell functionNon-polymorphic regionsT cell linesCostimulatory cellsMononuclear cellsIL-2Allospecific CTLICAM-1IFN-gammaVCAM-1Immunosuppressive drug CsAAbility of ECCostimulator activityVLA-4
1985
Prostaglandin E2 inhibits the activation of cloned T cell hybridomas.
Makoul G, Robinson D, Bhalla A, Glimcher L. Prostaglandin E2 inhibits the activation of cloned T cell hybridomas. The Journal Of Immunology 1985, 134: 2645-50. PMID: 2857750, DOI: 10.4049/jimmunol.134.4.2645.Peer-Reviewed Original ResearchConceptsIL-2 secretionT cell hybridomasProstaglandin E2T cellsStimulator cellsCell hybridomasTA3 cellsCAMP levelsMarked inhibitionConcentrations of PGE2M prostaglandin E2IL-2 productionT cell activationDose-dependent mannerT hybridoma cellsMitogenic signalsImmunosuppressive effectsInterleukin-2M. PretreatmentSignificant elevationCell activationPhysiologic concentrationsMin of additionSimilar pretreatmentDcAMP
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