2010
CD4+ T cells mediate mucosal and systemic immune responses to experimental hookworm infection
DONDJI B, SUN T, BUNGIRO RD, VERMEIRE JJ, HARRISON LM, BIFULCO C, CAPPELLO M. CD4+ T cells mediate mucosal and systemic immune responses to experimental hookworm infection. Parasite Immunology 2010, 32: 406-413. PMID: 20500671, PMCID: PMC3241967, DOI: 10.1111/j.1365-3024.2010.01204.x.Peer-Reviewed Original ResearchConceptsT cellsImmune responseHookworm infectionHost cellular immune responseExperimental hookworm infectionT-cell depletionMesenteric lymph nodesSystemic immune responsesCellular immune responsesHumoral immune responseIntestinal nematode infectionsIntestinal worm burdenResource-limited countriesHookworm antigensLymph nodesSevere anemiaIntraperitoneal injectionLymphocyte proliferationHookworm Ancylostoma ceylanicumIsotype controlDisease pathogenesisWorm burdenSyrian hamstersAncylostoma ceylanicumEffector role
2008
Role for Nitric Oxide in Hookworm-Associated Immune Suppression
Dondji B, Bungiro RD, Harrison LM, Vermeire JJ, Bifulco C, McMahon-Pratt D, Cappello M. Role for Nitric Oxide in Hookworm-Associated Immune Suppression. Infection And Immunity 2008, 76: 2560-2567. PMID: 18347036, PMCID: PMC2423093, DOI: 10.1128/iai.00094-08.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsHookworm infectionNitric oxideInfected animalsMesenteric lymph node cellsHost cellular immune responseCellular immune responsesLymph node cellsProliferative capacityT cell preparationsSurface immunoglobulin GParasite-induced immunosuppressionResource-poor countriesHookworm antigensMLN cellsLymphocyte subpopulationsPositive lymphocytesCellular immunityImmune suppressionLymphocyte proliferationNode cellsFluorescence-activated cell sortingInfected hamstersImmune responseAnimal studies
2004
Inhibition of alloresponse by a human trophoblast non-coding RNA suppressing class II transactivator promoter III and major histocompatibility class II expression in murine B-lymphocytes
Geirsson A, Bothwell AL, Hammond GL. Inhibition of alloresponse by a human trophoblast non-coding RNA suppressing class II transactivator promoter III and major histocompatibility class II expression in murine B-lymphocytes. The Journal Of Heart And Lung Transplantation 2004, 23: 1077-1081. PMID: 15454174, DOI: 10.1016/j.healun.2004.07.020.Peer-Reviewed Original ResearchConceptsClass II expressionCIITA promoter IIIPromoter IIIMajor histocompatibilityClass II transactivator promoter IIIMajor histocompatibility class II expressionMHC class II expressionConstitutive class II expressionClass II transcriptsAllograft toleranceLymphocyte proliferationT lymphocytesAllogenic responseLymphocyte stimulationMurine B lymphocytesB cellsB lymphocytesClass IIFlow cytometryFunctional affectsConcurrent suppressionBp 152AlloresponseSignificant suppressionCIITA promoter
2001
Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers
Redlich C, Stowe M, Wisnewski A, Eisen E, Karol M, Lemus R, Holm C, Chung J, Sparer J, Liu Y, Woskie S, Appiah‐Pippim J, Gore R, Cullen M. Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers. American Journal Of Industrial Medicine 2001, 39: 587-597. PMID: 11385643, DOI: 10.1002/ajim.1058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAir Pollutants, OccupationalAnalysis of VarianceAsthmaAutomobilesChi-Square DistributionCross-Sectional StudiesCyanatesEpidemiologic StudiesFemaleHumansIsocyanatesMaleMiddle AgedOccupational DiseasesOccupational ExposurePaintStatistics, NonparametricSurveys and QuestionnairesConceptsAuto body shop workersDiisocyanate asthmaLymphocyte proliferationHost risk factorsShortness of breathShop workersMethacholine responsivenessMethacholine challengeChest tightnessDiisocyanate exposureOccupational asthmaImmunologic responseRisk factorsPhysiologic changesImmune responseEpidemiologic studiesSurveillance studyPhysiologic responsesAsthmaOvert casesSymptomsExposure dataEpisodic exposureAuto body shopsExposureLymphocyte responses to stress in postpartum women: relationship to vagal tone
Redwine L, Altemus M, Leong Y, Carter C. Lymphocyte responses to stress in postpartum women: relationship to vagal tone. Psychoneuroendocrinology 2001, 26: 241-251. PMID: 11166487, DOI: 10.1016/s0306-4530(00)00049-4.Peer-Reviewed Original ResearchConceptsPoke-weed mitogenLymphocyte responsesLymphocyte proliferationVagal toneImmune responseNon-postpartum womenCellular immune responsesLymphocyte proliferation responseCardiac vagal toneBlood pressureHPA axisPostpartum womenFollicular phaseParturient womenVagal systemHeart rateProliferation responseEndocrine measuresWeed mitogenStress-induced changesPhytohemagglutininWomenAutonomic measuresBottlefeedingRegression analysis
2000
Ethyleneglycol-Bis-(β-Aminoethylether)Tetraacetate as a Blood Anticoagulant: Preservation of Antigen-Presenting Cell Function and Antigen-Specific Proliferative Response of Peripheral Blood Mononuclear Cells from Stored Blood
Kumar P, Satchidanandam V. Ethyleneglycol-Bis-(β-Aminoethylether)Tetraacetate as a Blood Anticoagulant: Preservation of Antigen-Presenting Cell Function and Antigen-Specific Proliferative Response of Peripheral Blood Mononuclear Cells from Stored Blood. MSphere 2000, 7: 578-583. PMID: 10882655, PMCID: PMC95917, DOI: 10.1128/cdli.7.4.578-583.2000.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAntigen-specific responsesBlood mononuclear cellsJapanese encephalitis virusLymphoproliferative responsesMononuclear cellsT cellsFresh peripheral blood mononuclear cellsAdherent antigen-presenting cellsAntigen-presenting cell functionAntigen-specific proliferative responsesAntigen-specific T cell linesAntigen-specific lymphoproliferative responsesEffector T cellsAntigen-presenting cellsAnticoagulant of choiceT cell linesJEV patientsLymphocyte proliferationAntigen stimulationInterleukin-2Proliferative responseStored bloodStimulation assaysEncephalitis virus
1999
Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma?
Wisnewski A, Lemus R, Karol M, Redlich C. Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma? Journal Of Allergy And Clinical Immunology 1999, 104: 341-347. PMID: 10452755, DOI: 10.1016/s0091-6749(99)70377-5.Peer-Reviewed Original ResearchConceptsIsocyanate-induced asthmaHuman lung epithelial cell lineEpithelial cell proteinsLung epithelial cell lineEpithelial cell lineLymphocyte proliferationProliferation of PBMCCell linesAirway inflammationAtopic subjectsNonasthmatic individualsHDI exposureAirway epitheliumImmunostimulatory potentialAsthmaCell proteinsWestern blottingPotential roleProliferationExposureHDI concentrationCross-linking chemicalsCell polypeptidesConjugation patternSubjectsImpact of different low-density lipoprotein (LDL) receptor mutations on the ability of LDL to support lymphocyte proliferation
Martínez-Botas J, Suárez Y, Reshef A, Carrero P, Ortega H, Gómez-Coronado D, Teruel J, Leitersdorf E, Lasunción M. Impact of different low-density lipoprotein (LDL) receptor mutations on the ability of LDL to support lymphocyte proliferation. Metabolism 1999, 48: 834-839. PMID: 10421221, DOI: 10.1016/s0026-0495(99)90214-7.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinAbility of LDLFamilial hypercholesterolemiaReceptor mutationsLow-density lipoprotein receptor mutationNormal low density lipoproteinHomozygous familial hypercholesterolemiaDifferent LDL receptor mutationsEndogenous cholesterol synthesisLDL receptor mutationsMitogen-stimulated lymphocytesLymphocyte proliferationPeripheral lymphocytesLDL particlesLymphocytesMitogenic effectCytometric analysisCholesterol synthesisLDL bindingCase 2Case 1Similar extentCompound heterozygotesDefective internalizationDifferent phenotypes
1997
Local delivery of c‐myb antisense oligonucleotides during balloon angioplasty
Azrin M, Mitchel J, Bow L, Pedersen C, Cartun R, Aretz T, Waters D, McKay R. Local delivery of c‐myb antisense oligonucleotides during balloon angioplasty. Catheterization And Cardiovascular Interventions 1997, 41: 232-240. PMID: 9213020, DOI: 10.1002/(sici)1097-0304(199707)41:3<232::aid-ccd2>3.0.co;2-7.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAnimalsAutoradiographyCell DivisionCoronary DiseaseCoronary VesselsDrug Delivery SystemsFeasibility StudiesFemaleLymphocyte ActivationMiceMicroscopy, FluorescenceMuscle, Smooth, VascularOligonucleotides, AntisenseProliferating Cell Nuclear AntigenProto-Oncogene ProteinsProto-Oncogene Proteins c-mybSwineTrans-ActivatorsConceptsSmooth muscle cell proliferationMuscle cell proliferationIntraluminal deliveryBalloon angioplastyCell proliferationLess cellular proliferationQuantitative immunohistochemical stainingCatheter-based systemC-MybC-myb antisenseCell nuclear antigenArterial injuryPeripheral arteriesLymphocyte proliferationContralateral vesselCarotid arteryImmunohistochemical stainingAngioplastyArterial mediaArterial segmentsNuclear antigenLocal deliveryCellular proliferationArteryProliferationNITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking J, Xie Q, Nathan C. NITRIC OXIDE AND MACROPHAGE FUNCTION. Annual Review Of Immunology 1997, 15: 323-350. PMID: 9143691, DOI: 10.1146/annurev.immunol.15.1.323.ChaptersConceptsExpression of NOS2Nitric oxide synthaseAdaptive immune systemNormal host cellsRemarkable molecular machinesInflammatory diseasesLymphocyte proliferationNO pathwayOxide synthaseImmune responseMacrophage productsMacrophage functionSuppressive effectImmune systemNOS2Nitric oxideHigh-output isoformTumor cellsMacrophagesCytotoxic actionElevated Ca2Transcriptional inductionFunctional dimerCytotoxic activityMolecular machines
1994
Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells.
Viney J, Dianda L, Roberts S, Wen L, Mallick C, Hayday A, Owen M. Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 11948-11952. PMID: 7991563, PMCID: PMC45353, DOI: 10.1073/pnas.91.25.11948.Peer-Reviewed Original ResearchConceptsTCR gamma deltaTCR alpha betaGamma deltaAlpha betaT-cell receptor alpha betaT cell receptor expressionSurface activation markersAlpha mutant miceWild-type animalsActivation markersEnvironmental antigensLymphoid componentLymphocyte proliferationLymphoid organsLymphoid tissueReceptor expressionT cellsImmune responseMutant miceAbsolute numberMiceSubstantial proportionCell populationsPrimary regulatorBeta
1993
Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse
de Souza MS, Smith AL, Beck DS, Terwilliger GA, Fikrig E, Barthold SW. Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse. Infection And Immunity 1993, 61: 1814-1822. PMID: 8478071, PMCID: PMC280770, DOI: 10.1128/iai.61.5.1814-1822.1993.Peer-Reviewed Original ResearchConceptsT cell responsesDelayed-type hypersensitivity responseVigorous T cell responseRecipient C3H miceCell-mediated responsesAntigen-specific proliferationBorrelia burgdorferi infectionB cell mitogensAntigen-specific assaysLaboratory miceAdoptive transferImmune dysfunctionHypersensitivity responseResistant miceLymphocyte proliferationLymphoid organsBurgdorferi infectionC3H miceInterleukin-2Prostaglandin productionB cellsDiminished numberLyme borreliosisImpaired proliferationLong-term studiesNitric Oxide Modulates Lymphocyte Proliferation But Not Secretion of IL-2
Huot AE, Moore AL, Roberts JD, Hacker MP. Nitric Oxide Modulates Lymphocyte Proliferation But Not Secretion of IL-2. Immunological Investigations 1993, 22: 319-327. PMID: 7689536, DOI: 10.3109/08820139309063411.Peer-Reviewed Original ResearchConceptsLymphocyte proliferationBAL cellsIL-2Nitric oxideNO synthase inhibitor NG-monomethylSynthase inhibitor NG-monomethylExcess IL-2Bronchoalveolar lavage cellsInhibitor NG-monomethylCytokines IL-2Time of sacrificeIL-2 productionInterleukin-2 productionModulate lymphocyte proliferationSource of NOIL-2-dependent CTLL-2 cellsLavage cellsNG-monomethylCytokine releaseIntratracheal doseCTLL-2 cellsL-arginineLymphocyte growthMarked inhibitionNO inhibits
1980
Persistent immunologic abnormalities in long-term survivors of advanced Hodgkin's disease.
Fisher R, DeVita V, Bostick F, Vanhaelen C, Howser D, Hubbard S, Young R. Persistent immunologic abnormalities in long-term survivors of advanced Hodgkin's disease. Annals Of Internal Medicine 1980, 92: 595-9. PMID: 6992672, DOI: 10.7326/0003-4819-92-5-595.Peer-Reviewed Original ResearchConceptsLong-term survivorsMitogen-induced lymphocyte proliferationPersistent immunologic abnormalitiesHodgkin's diseaseImmunologic abnormalitiesE rosettesLymphocyte proliferationAdvanced diffuse histiocytic lymphomaDepressed cellular immunityAdvanced Hodgkin's diseaseDisease-free intervalDiffuse histiocytic lymphomaB cell numbersNormal control subjectsComparable chemotherapyMOPP chemotherapyUntreated patientsCellular immunityControl subjectsHistiocytic lymphomaImmunologic studiesNormal rangeControl populationChemotherapyAbnormalities
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