2025
Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei Z, Hu W, Sun G, Huang G, He C, Fretz J, Hettinghouse A, Liu R, Cai X, Zhang M, Chen Y, Jiang N, He M, Wiznia D, Xu H, Chen Z, Chen L, Tang K, Zhou H, Liu C. Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss. Cell Research 2025, 35: 23-44. PMID: 39743632, PMCID: PMC11701132, DOI: 10.1038/s41422-024-01016-0.Peer-Reviewed Original ResearchConceptsGC-induced osteoporosisBone lossInflammatory arthritisAdverse effects of dexamethasoneGlucocorticoid-induced bone lossHigh-dose dexamethasoneEffect of dexamethasoneFDA-approved drug librarySynthetic GCTreat inflammatory arthritisImmunosuppressive drugsPrescribed anti-inflammatoryGC receptorCombinatorial administrationSide effectsLow affinityGlucocorticoidOsteoporosisDexamethasoneReceptorsAdverse effectsBinding receptorsAnti-inflammatoryDrug libraryTau deficiency
2016
Protective effects of ginsenoside F2 on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice
Park S, Seo W, Eun H, Kim S, Jo E, Kim M, Choi W, Lee J, Shim Y, Cui C, Kim S, Hwang C, Jeong W. Protective effects of ginsenoside F2 on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice. Biochemical And Biophysical Research Communications 2016, 478: 1713-1719. PMID: 27596969, DOI: 10.1016/j.bbrc.2016.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsDermatitisEar, ExternalEdemaFlow CytometryGene ExpressionGinsenosidesInterleukin-17MaleMice, Inbred C57BLMice, KnockoutNeutrophilsProtective AgentsReactive Oxygen SpeciesReceptors, Antigen, T-Cell, gamma-deltaReverse Transcriptase Polymerase Chain ReactionT-LymphocytesTetradecanoylphorbol AcetateConceptsSkin inflammationT cellsAnti-inflammatory roleProtective effectIL-17Reactive oxygen speciesProduction of IL-17Protective effect of dexamethasoneVehicle-treated miceEars of miceTPA-treated groupExpression of inflammatory mediatorsEffect of dexamethasoneFlow cytometry analysisIL-17AEar thicknessGeneration of reactive oxygen speciesInterleukin-17Dermal inflammationInflammatory mediatorsTopical useInflammatory responseTherapeutic approachesTPA treatmentInflammation
2003
Borrelia burgdorferi transcriptome in the central nervous system of non-human primates
Narasimhan S, Camaino M, Liang FT, Santiago F, Laskowski M, Philipp MT, Pachner AR, Radolf JD, Fikrig E. Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 15953-15958. PMID: 14671329, PMCID: PMC307674, DOI: 10.1073/pnas.2432412100.Peer-Reviewed Original ResearchConceptsNon-human primate modelB. burgdorferiEffect of dexamethasoneCentral nervous systemHost metabolic pathwaysNon-human primatesNeurological symptomsPaucibacillary natureCNS milieuImmune statusCommon manifestationPrimate modelNervous systemExpression profilesLyme diseaseHost factorsHeart tissueGene expressionB. burgdorferi transcriptomeBorrelia burgdorferiNHPNeuroborreliosisImmunocompetentVivo gene expressionBurgdorferi
1999
Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone.
Milner J, Kent S, Ashley T, Wilson S, Strominger J, Hafler D. Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. The Journal Of Immunology 1999, 163: 2522-9. PMID: 10452989, DOI: 10.4049/jimmunol.163.5.2522.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAntibodies, BlockingAntibodies, MonoclonalAntigens, CD1Antigens, CD1dAntigens, Differentiation, B-LymphocyteApoptosisAutocrine CommunicationCD3 ComplexCD4-Positive T-LymphocytesClone CellsDexamethasoneDose-Response Relationship, Immunologicfas ReceptorHistocompatibility Antigens Class IIHumansImmunosuppressive AgentsInterleukin-2Lymphocyte ActivationReceptors, Antigen, T-Cell, alpha-betaSignal TransductionT-Lymphocyte SubsetsConceptsActivation-induced cell deathT cell clonesT cellsTCR signal strengthCell clonesAutocrine IL-2 productionNK T cellsT cell responsesT cell subsetsInhibition of CD4Anti-CD3 stimulationT cell proliferationEffect of dexamethasoneMHC class IIIL-2 productionPresence of dexamethasoneExogenous corticosteroidsCell subsetsImmunomodulatory consequencesDexamethasone treatmentImmune responseCD4High dosesLow dosesCell responses
1995
Study on IL-8 Expression in Peripheral Blood Monocytes
Kim J, Lee J, Kang M, Park J, Yoo C, Kim Y, Han S, Shim Y. Study on IL-8 Expression in Peripheral Blood Monocytes. Tuberculosis And Respiratory Diseases 1995, 42: 703-712. DOI: 10.4046/trd.1995.42.5.703.Peer-Reviewed Original ResearchPeripheral blood monocytesIL-8 mRNA expressionIL-8 mRNAIL-8 protein releaseEffect of dexamethasoneIL-8IFN-gammaBlood monocytesSystemic inflammationMRNA expressionTissue injuryInflammatory reactionLPS stimulationImportant immune effector cellsProtein expressionHuman peripheral blood monocytesImmune effector cellsIL-8 productionIL-8 expressionIL-8 proteinMonocytes/macrophagesNorthern blot analysisBlot analysisEffector cellsSuch inflammation
1993
Glucocorticoids stimulate Na+/H+ antiporter in OKP cells
Baum M, Cano A, Alpern RJ. Glucocorticoids stimulate Na+/H+ antiporter in OKP cells. American Journal Of Physiology 1993, 264: f1027-f1031. PMID: 8391752, DOI: 10.1152/ajprenal.1993.264.6.f1027.Peer-Reviewed Original ResearchConceptsOKP cellsProximal tubule acidificationEffect of dexamethasoneAntiporter activityTime-dependent stimulationM aldosteroneHemodynamic changesTubule acidificationSystemic administrationDependent pH recoveryDexamethasoneM dexamethasoneAcid loadStimulatory effectGlucocorticoidsPH recoveryStimulationPH-sensitive dyePresent studyMaximal velocityCellsDirect effectAldosteronePrevious studiesActivity
1988
Glucocorticoids have a different action than aldosterone on target tissue
Halevy J, Boulpaep E, Budinger M, Binder H, Hayslett J. Glucocorticoids have a different action than aldosterone on target tissue. American Journal Of Physiology 1988, 254: f153-f158. PMID: 3337244, DOI: 10.1152/ajprenal.1988.254.1.f153.Peer-Reviewed Original ResearchConceptsRU 28362Same doseInhibitory actionDexamethasone-treated animalsBody wt-1Effects of glucocorticoidsEffect of dexamethasoneReceptor-independent actionsRat distal colonSodium channel blockersMarked inhibitory actionEquivalent short-circuit currentBasolateral potential differenceAldosterone receptorsEpithelial changesDistal colonChannel blockersAldosteroneSynthetic glucocorticoidDay 1WT-1Large intestineGlucocorticoidsEpithelial resistanceMarked inhibition
1986
Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships
Rooney S, Dynia D, Smart D, Chu A, Ingleson L, Wilson C, Gross I. Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships. Biochimica Et Biophysica Acta 1986, 888: 208-216. PMID: 3017448, DOI: 10.1016/0167-4889(86)90023-6.Peer-Reviewed Original ResearchConceptsEffect of dexamethasoneDexamethasone bindingCholine-phosphate cytidylyltransferase activitySpecific dexamethasone bindingFetal lung maturationFetal rat lung explantsCholine-phosphate cytidylyltransferaseSpecific nuclear bindingCytidylyltransferase activityRat lung explantsReceptor-mediated processSupernatant fractionFetal rat lungDose-response curveDexamethasone-treated culturesLung maturationGlucocorticoid bindingGlucocorticoid actionDe novo phosphatidylcholine synthesisLung explantsRat lungDexamethasoneGlucocorticoid stimulationStimulatory effectCholine incorporation
1982
The Effect of Dexamethasone on Renal Electrolyte Excretion in the Adrenalectomized Rat
BIA M, TYLER K, DEFRONZO R. The Effect of Dexamethasone on Renal Electrolyte Excretion in the Adrenalectomized Rat. Endocrinology 1982, 111: 882-888. PMID: 7106056, DOI: 10.1210/endo-111-3-882.Peer-Reviewed Original ResearchConceptsDose of dexamethasoneHigh dose of dexamethasoneRenal electrolyte excretionSodium excretionAdrenalectomized ratsK excretionElectrolyte excretionHigh dosesLow dosesLow dose of dexamethasoneLow dose of aldosteroneUrinary sodium excretionDose of aldosteroneDecreased sodium excretionLowest effective doseGlomerular filtration rateRenal potassium excretionUrinary K excretionAffecting sodium excretionK concentrationEffect of dexamethasoneAcute administrationUrinary potassiumPlasma K concentrationPotassium excretion
1974
Effect of dexamethasone on herpes simplex virus type 2 infection in vitro
COSTA J, YEE C, TROOST T, RABSON A. Effect of dexamethasone on herpes simplex virus type 2 infection in vitro. Nature 1974, 252: 745-746. PMID: 4373659, DOI: 10.1038/252745a0.Peer-Reviewed Original ResearchConceptsHSV-2 infectionHerpes simplex virus type 2 infectionSimplex virus type 2 infectionVirus type 2 infectionEffect of corticosteroidsSimplex type 2Type 2 infectionEffect of dexamethasoneMouse mammary tumorsPresence of steroidsGlucocorticoid influencesEpidemiological evidenceMammary tumorsPhysiological dosesVirus-infected culturesType 2Plaque formationMalignant transformationViral strainsInfectionTypes of cellsMurine leukemia virusMouse embryo fibroblastsCorticosteroidsLeukemia virus
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