2015
IL-7Ralow memory CD8+ T cells are clonally anergic cells and defect in aerobic glycolysis pathway (HUM4P.274)
Sim J, Kim J, Seol M, Lee S, Cho B, Ko Y, Oh K, Lee D, Kim J, Park A, Kang I, Choi K, Kim H. IL-7Ralow memory CD8+ T cells are clonally anergic cells and defect in aerobic glycolysis pathway (HUM4P.274). The Journal Of Immunology 2015, 194: 122.5-122.5. DOI: 10.4049/jimmunol.194.supp.122.5.Peer-Reviewed Original ResearchMemory CD8T cellsIL-2 stimulationCD3/CD28 AbSubset of CD8TCR stimulationExpression of GATA3Aerobic glycolysis pathwayPMA/ionomycin treatmentDistal TCR signalingAnergic statusCD28 AbsPeripheral bloodHuman CD8IL-2C-myc expressionCD8IL-7Anergic cellsCalcium fluxHuman immunologyNF-AT1Nuclear translocationAerobic glycolysisIonomycin treatment
2014
TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219)
Nickerson K, Christensen S, Cullen J, Meng W, Luning Prak E, Shlomchik M. TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219). The Journal Of Immunology 2014, 192: 46.10-46.10. DOI: 10.4049/jimmunol.192.supp.46.10.Peer-Reviewed Original ResearchAnti-DNA B cellsSystemic lupus erythematosusB cellsB cell receptorAnti-DNA autoantibodiesLupus erythematosusBreaking B-cell toleranceAbsence of TLR9Reactive B cellsAutoimmunity in vivoB cell toleranceAutoimmune-prone MRLFunctional anergyAutoreactive cellsPeripheral repertoireAnergic cellsBone marrowExtrafollicular pathwayReceptor editingClinical hallmarkBCR signalingMouse modelBCR expressionTLR9Healthy individualsHuman IL-7Rα low memory CD8+ T cells are clonal anergic cells being reversed by exogenous IL-2 (IRC10P.469)
Sim J, Cho B, Lee S, Ko Y, Seol M, Kim J, Oh K, Lee D, Kang I, Choi K, Kim H. Human IL-7Rα low memory CD8+ T cells are clonal anergic cells being reversed by exogenous IL-2 (IRC10P.469). The Journal Of Immunology 2014, 192: 192.7-192.7. DOI: 10.4049/jimmunol.192.supp.192.7.Peer-Reviewed Original Research
2013
TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation
Nickerson KM, Christensen SR, Cullen JL, Meng W, Prak E, Shlomchik MJ. TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation. The Journal Of Immunology 2013, 190: 1447-1456. PMID: 23296704, PMCID: PMC3563726, DOI: 10.4049/jimmunol.1202115.Peer-Reviewed Original ResearchConceptsAnti-DNA B cellsB cellsBone marrowAbsence of TLR9Autoimmune prone animalsAutoimmune-prone MRLSystemic lupus erythematosusAnergic B cellsB cell compartmentB cell toleranceAb-forming cellsL chain editingB cell life spanFunctional anergyLupus erythematosusTLR9 expressionAutoreactive cellsPeripheral activationExtrafollicular pathwayPeripheral repertoireSystemic autoimmunityMouse modelAnergic cellsTLR9Cell life span
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