1985
Prostaglandin E2 inhibits the activation of cloned T cell hybridomas.
Makoul G, Robinson D, Bhalla A, Glimcher L. Prostaglandin E2 inhibits the activation of cloned T cell hybridomas. The Journal Of Immunology 1985, 134: 2645-50. PMID: 2857750, DOI: 10.4049/jimmunol.134.4.2645.Peer-Reviewed Original ResearchConceptsIL-2 secretionT cell hybridomasProstaglandin E2T cellsStimulator cellsCell hybridomasTA3 cellsCAMP levelsMarked inhibitionConcentrations of PGE2M prostaglandin E2IL-2 productionT cell activationDose-dependent mannerT hybridoma cellsMitogenic signalsImmunosuppressive effectsInterleukin-2M. PretreatmentSignificant elevationCell activationPhysiologic concentrationsMin of additionSimilar pretreatmentDcAMP
1978
Rabbit antiserum to human B-cell alloantigens II. Mechanism of inhibition of stimulation in the mixed lymphocyte response
Geier S, Cresswell P. Rabbit antiserum to human B-cell alloantigens II. Mechanism of inhibition of stimulation in the mixed lymphocyte response. Cellular Immunology 1978, 35: 392-402. PMID: 145900, DOI: 10.1016/0008-8749(78)90158-2.Peer-Reviewed Original ResearchConceptsAntibody-dependent cell-mediated cytotoxicityMixed lymphocyte responseAnti-B cell serumLymphocyte responsesDependent cell-mediated cytotoxicityInhibition of monocyteHuman B cell alloantigensADCC effector cellsCell-mediated cytotoxicityImmunoglobulin-positive cellsB-cell alloantigensRabbit antiserumEffector cellsMLR suppressionImmune eliminationStimulator cellsPositive cellsLevel of inhibitionMarked reductionCell populationsChicken antiseraAntiserumSimilar specificityMechanism of inhibitionFc region
1976
Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells
Janeway C, Mosier D, Tigelaar R. Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells. European Journal Of Immunology 1976, 6: 747-750. PMID: 138373, DOI: 10.1002/eji.1830061017.Peer-Reviewed Original ResearchConceptsMixed lymphocyte reactionFresh spleen cellsSpleen cellsLymphocyte reactionOne-way mixed-lymphocyte reactionPrimary mixed lymphocyte reactionMouse strainsStimulator activityCytotoxic T cellsStrong mixed lymphocyte reactionsUnrelated mouse strainsCongenic mouse strainsCytotoxic cellsStimulator cellsT cellsRelease assaysSpecific lossCell activityResidual cellsB subregionRestricted expressionLymphocytesSuch cellsAntigenCells
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