2021
Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents
Lévy R, Langlais D, Béziat V, Rapaport F, Rao G, Lazarov T, Bourgey M, Zhou Y, Briand C, Moriya K, Ailal F, Avery D, Markle J, Lim A, Ogishi M, Yang R, Pelham S, Emam M, Migaud M, Deswarte C, Habib T, Saraiva L, Moussa E, Guennoun A, Boisson B, Belkaya S, Martinez-Barricarte R, Rosain J, Belkadi A, Breton S, Payne K, Benhsaien I, Plebani A, Lougaris V, Di Santo J, Neven B, Abel L, S. C, Bousfiha A, Marr N, Bustamante J, Liu K, Gros P, Geissmann F, Tangye S, Casanova J, Puel A. Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents. Journal Of Clinical Investigation 2021, 131: e150143. PMID: 34623332, PMCID: PMC8409595, DOI: 10.1172/jci150143.Peer-Reviewed Original ResearchConceptsCD4+ T cellsMemory CD4+ T cellsC-Rel deficiencyT cellsMyeloid cellsLymphoid cellsB cellsC-RelMultiple infectious agentsNaive CD4+ T cellsCD8+ T cellsAntigen-presenting cell functionConventional DC1sFrequency of NKMemory B cellsNaive T cellsNaive B cellsFunctional deficitsReduced IL-2 productionProduction of Th1Infectious agentsIL-23 productionIL-2 productionInduction of CD86 expressionB cell survivalProtective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis
Wang N, Wu W, Qiang C, Ma N, Wu K, Liu D, Wang J, Yang X, Xue L, Diao T, Liu J, Li A, Zhang B, Li Z, Farrar C, Banda N, Bayarri‐Olmos R, Garred P, Zhou W, Li K. Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis. Arthritis & Rheumatology 2021, 73: 1430-1440. PMID: 33605085, PMCID: PMC8324516, DOI: 10.1002/art.41696.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisRA patientsJoint inflammationInflammatory cytokinesMouse modelAPC activationMurine collagen-induced arthritis (CIA) modelSubsequent T cell responsesC-reactive protein levelsAntigen-presenting cell functionCollagen-induced arthritis modelCL-11Clinical arthritis scoreDisease Activity ScoreSeverity of CIAErythrocyte sedimentation rateT cell responsesAdaptive immune responsesWild-type miceCollectin-11Soluble C-type lectinArthritis scorePharmacologic treatmentActivity scoreSevere arthritis
2000
Ethyleneglycol-Bis-(β-Aminoethylether)Tetraacetate as a Blood Anticoagulant: Preservation of Antigen-Presenting Cell Function and Antigen-Specific Proliferative Response of Peripheral Blood Mononuclear Cells from Stored Blood
Kumar P, Satchidanandam V. Ethyleneglycol-Bis-(β-Aminoethylether)Tetraacetate as a Blood Anticoagulant: Preservation of Antigen-Presenting Cell Function and Antigen-Specific Proliferative Response of Peripheral Blood Mononuclear Cells from Stored Blood. MSphere 2000, 7: 578-583. PMID: 10882655, PMCID: PMC95917, DOI: 10.1128/cdli.7.4.578-583.2000.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAntigen-specific responsesBlood mononuclear cellsJapanese encephalitis virusLymphoproliferative responsesMononuclear cellsT cellsFresh peripheral blood mononuclear cellsAdherent antigen-presenting cellsAntigen-presenting cell functionAntigen-specific proliferative responsesAntigen-specific T cell linesAntigen-specific lymphoproliferative responsesEffector T cellsAntigen-presenting cellsAnticoagulant of choiceT cell linesJEV patientsLymphocyte proliferationAntigen stimulationInterleukin-2Proliferative responseStored bloodStimulation assaysEncephalitis virus
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