2023
Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment
Blaine S, Fogelman N, Lacadie C, Constable T, Sinha R. Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment. Alcohol Clinical And Experimental Research 2023, 47: 1067-1078. PMID: 37070596, PMCID: PMC10289130, DOI: 10.1111/acer.15082.Peer-Reviewed Original ResearchAlcohol taste testFunctional magnetic resonance imagingAlcohol motivationSupplementary motor areaOrbitofrontal cortexInferior frontal gyrus regionsPerfusion functional magnetic resonance imagingEnhanced neural responseNeural reward responsesMedial orbitofrontal cortexPlacebo sessionAlcohol use disorderBrain reward regionsPlacebo-controlled effectsNeural processesOFC responsesReward responsesNeural responsesPlacebo beerSocial drinkersCerebral blood flowReward regionsBD relativeVentral striatumAlcohol effects
2008
The Effects of Methylphenidate on Decision Making in Attention-Deficit/Hyperactivity Disorder
DeVito EE, Blackwell AD, Kent L, Ersche KD, Clark L, Salmond CH, Dezsery AM, Sahakian BJ. The Effects of Methylphenidate on Decision Making in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2008, 64: 636-639. PMID: 18504036, PMCID: PMC2577132, DOI: 10.1016/j.biopsych.2008.04.017.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCambridge Gamble TaskADHD groupHyperactivity disorderDecision-making cognitionDecision-making deficitsEffects of methylphenidatePoor decision makingParent-reported symptomsHealthy age-matched control groupNeuropsychological markersEveryday behaviorStimulant medicationDisruptive behaviorPoor decisionsPoor judgmentBetting behaviorLittle empirical dataControl subjectsPlacebo sessionAge-matched control groupTaskDecision makingMethylphenidatePlacebo-controlled trial
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