2024
Drawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking
Harris B, Sinha R, Goldfarb E. Drawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking. Journal Of Neuroscience 2024, 44: e1027242024. PMID: 39147591, PMCID: PMC11450530, DOI: 10.1523/jneurosci.1027-24.2024.Peer-Reviewed Original ResearchAlcohol motivationInfluence later behaviorEnhance memorySalience responseFemale social drinkersAlcohol drinkingEmotionally salient experiencesResponse to alcoholDouble-blind cross-over designMemory biasSalient memoriesAlcohol-related eventsRisky alcohol drinkingSocial drinkersMotivated behaviorMaladaptive consequencesLateral behaviorCross-over designRisky drinkingMemoryRodent modelsHuman researchSalienceRisky drinkersCortisol
2022
Increased Voluntary Alcohol Consumption in Mice Lacking GABAB(1) Is Associated With Functional Changes in Hippocampal GABAA Receptors
Floris G, Asuni G, Talani G, Biggio F, Pisu M, Zanda M, Contu L, Maciocco E, Serra M, Follesa P. Increased Voluntary Alcohol Consumption in Mice Lacking GABAB(1) Is Associated With Functional Changes in Hippocampal GABAA Receptors. Frontiers In Behavioral Neuroscience 2022, 16: 893835. PMID: 35755407, PMCID: PMC9218813, DOI: 10.3389/fnbeh.2022.893835.Peer-Reviewed Original ResearchVoluntary alcohol consumptionAssociated with functional changesBlood alcohol concentrationAlcohol consumptionIncrease voluntary alcohol consumptionHippocampal GABA<sub>A</KO miceAlcohol drinking behaviorAlcohol drinkingAlcohol use disorderResponse to alcoholExcessive alcohol drinkingAcute alcohol administrationNeuroactive steroid levelsHippocampal GABAA receptorsAdministration of alcoholSynaptic GABA<sub>A</High blood alcohol concentrationsIncreased alcohol consumptionInvestigate alcohol consumptionNeurosteroid responseHippocampal levelsUse disorderBrain regionsAlcohol administration
2016
Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics
Yoder K, Albrecht D, Dzemidzic M, Normandin M, Federici L, Graves T, Herring C, Hile K, Walters J, Liang T, Plawecki M, O'Connor S, Kareken D. Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug And Alcohol Dependence 2016, 160: 163-169. PMID: 26832934, PMCID: PMC5074339, DOI: 10.1016/j.drugalcdep.2016.01.001.Peer-Reviewed Original ResearchConceptsSample of social drinkersNontreatment-seeking alcoholicsSocial drinkersVentral striatumDopamine releaseAlcohol intoxicationAlcohol-induced dopamine releaseVoxel-wise binding potentialTarget breath alcohol concentrationEffects of alcohol intoxicationRight ventral striatumInduce dopamine releaseStriatal DA systemIntravenous alcohol infusionAlcohol use disorderResponse to alcoholBreath alcohol concentrationDA responseStriatal dopamineDA systemTarget BrACAlcohol clampUse disorderDependent drinkersAlcohol infusion
2015
Differences in subjective response to alcohol by gender, family history, heavy episodic drinking, and cigarette use: refining and broadening the scope of measurement.
Morean M, Corbin W, Treat T. Differences in subjective response to alcohol by gender, family history, heavy episodic drinking, and cigarette use: refining and broadening the scope of measurement. Journal Of Studies On Alcohol And Drugs 2015, 76: 287-95. PMID: 25785804, PMCID: PMC5374480, DOI: 10.15288/jsad.2015.76.287.Peer-Reviewed Original ResearchConceptsSubjective response to alcoholSubjective Effects of Alcohol ScaleResponse to alcoholHigh arousalPlacebo-controlled alcohol administration studyFamily history of alcoholismEffects of Alcohol ScaleMultigroup confirmatory factor analysisAlcohol administration studyMean-level comparisonsCigarette smoking statusFamily historyHistory of alcoholismHeavy drinking statusConfirmatory factor analysisHeavy episodic drinkingDrinking statusSmoking statusAlcohol ScaleSubjective effectsHeavy episodic drinkersSimulated bar settingEpisodic drinkersScalar MIEpisodic drinking
2010
Subjective Response to Alcohol: A Critical Review of the Literature
Morean M, Corbin W. Subjective Response to Alcohol: A Critical Review of the Literature. Alcohol Clinical And Experimental Research 2010, 34: 385-395. PMID: 20028359, DOI: 10.1111/j.1530-0277.2009.01103.x.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSubjective response to alcoholResponse to alcoholBlood alcohol curveSubjective responsesAlcohol effectsDevelopment of alcohol use disordersAlcohol’s positive effectsAlcohol challenge paradigmHigh-risk individualsAssessment of subjective responseChallenge paradigmNegative reinforcementAlcohol curveImpairing effectsUse disorderCognitive/behavioral impairmentDrinking behaviorAlcohol problemsGenetic influencesLaboratory-based researchPartial supportAlcohol usePlacebo-ControlledSensitive to negative effects
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