2023
Mobilizing or Sedative Effects? A Narrative Review of the Association Between Intergroup Contact and Collective Action Among Advantaged and Disadvantaged Groups
Cocco V, Vezzali L, Stathi S, Di Bernardo G, Dovidio J. Mobilizing or Sedative Effects? A Narrative Review of the Association Between Intergroup Contact and Collective Action Among Advantaged and Disadvantaged Groups. Personality And Social Psychology Review 2023, 28: 119-180. PMID: 37864514, PMCID: PMC11010580, DOI: 10.1177/10888683231203141.Peer-Reviewed Original Research
2022
Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers
Ralevski E, Horvath T, Shanabrough M, Newcomb J, Pisani E, Petrakis I. Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers. Alcohol And Alcoholism 2022, 58: 100-106. PMID: 36382470, PMCID: PMC9830489, DOI: 10.1093/alcalc/agac058.Peer-Reviewed Original Research
2017
Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol
Ralevski E, Horvath TL, Shanabrough M, Hayden R, Newcomb J, Petrakis I. Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol. Alcohol And Alcoholism 2017, 52: 431-438. PMID: 28481974, DOI: 10.1093/alcalc/agx022.Peer-Reviewed Original ResearchConceptsGhrelin levelsDoses of alcoholHealthy social drinkersSubjective effectsTG levelsAlcohol infusionSedative effectsLow doseHigh doseOral alcohol administrationIntravenous alcohol infusionFeeding-related peptidesSocial drinkersAlcohol administrationIntravenous alcoholOral alcoholGhrelinPercent changeInfusionRewarding propertiesBehavioral effectsAlcohol effectsDoseTime pointsSignificant predictors
2013
Sodium oxybate–induced central sleep apneas
Frase L, Schupp J, Sorichter S, Randelshofer W, Riemann D, Nissen C. Sodium oxybate–induced central sleep apneas. Sleep Medicine 2013, 14: 922-924. PMID: 23834969, DOI: 10.1016/j.sleep.2013.03.023.Peer-Reviewed Original ResearchConceptsCentral sleepBreathing disordersCheyne-Stokes patternSleep-disordered breathingUse of GHBTreatment of narcolepsyCurrent safety recommendationsSodium oxybateSedative effectsPatientsSleepGHBNarcolepsySafety recommendationsHuman brainConstant treatmentFurther investigationDe novo emergenceDisordersSafety guidelinesTreatmentNovo emergenceFirst reportDiscontinuationCataplexyTwo cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive–compulsive disorder and a history of major depressive disorder
Niciu MJ, Grunschel B, Corlett PR, Pittenger C, Bloch MH. Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive–compulsive disorder and a history of major depressive disorder. Journal Of Psychopharmacology 2013, 27: 651-654. PMID: 23676198, DOI: 10.1177/0269881113486718.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAntidepressant effectsPsychiatric comorbidityComorbid depressionNon-competitive N-methyl-D-aspartate (NMDA) receptor antagonistN-methyl-D-aspartate receptor antagonistTreatment-refractory obsessive-compulsive disorderAcute antidepressant effectsTreatment-resistant unipolarOpen-label trialSevere respiratory depressionAdverse neuropsychiatric effectsComorbid psychiatric disordersMinimal depressive symptomsOff-label useMajor depressive disorderStart of infusionRespiratory depressionIntravenous ketamineNeuropsychiatric effectsKetamine infusionBipolar depressionReceptor antagonistDepressive disorderSedative effects
2010
The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative‐Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice
Kamens HM, Andersen J, Picciotto MR. The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative‐Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice. Alcohol Clinical And Experimental Research 2010, 34: 2053-2060. PMID: 20946306, PMCID: PMC2988947, DOI: 10.1111/j.1530-0277.2010.01301.x.Peer-Reviewed Original ResearchConceptsSedative-hypnotic effectsBaseline locomotor activityFixed-speed rotarodAlcohol abuseEthanol consumptionNicotinic acetylcholine receptor partial agonist vareniclineLocomotor activityEthanol-induced motor incoordinationAbility of vareniclineAcute ethanol injectionDuration of LORRLocomotor activity chambersEffects of vareniclineAcute ethanol administrationNew pharmacologic strategiesDowel testDuration of lossPartial agonist vareniclineEthanol-induced ataxiaBalance beamNicotinic modulationPharmacologic strategiesMotor incoordinationEthanol administrationSedative effectsAversive Effects of Ethanol in Adolescent Versus Adult Rats: Potential Causes and Implication for Future Drinking
Schramm‐Sapyta N, DiFeliceantonio AG, Foscue E, Glowacz S, Haseeb N, Wang N, Zhou C, Kuhn CM. Aversive Effects of Ethanol in Adolescent Versus Adult Rats: Potential Causes and Implication for Future Drinking. Alcohol Clinical And Experimental Research 2010, 34: 2061-2069. PMID: 20860614, PMCID: PMC2988872, DOI: 10.1111/j.1530-0277.2010.01302.x.Peer-Reviewed Original ResearchConceptsAversive effectsAdolescents Versus AdultsProblem drinking behaviorDrug seeking behaviorBlood ethanol concentrationTaste aversionFuture drinkingAdolescent ratsAge differencesDrugs of abuseEthanol CTADrug takingDrinking behaviorAdolescentsPhysiologic effectsAdult ratsTeenage yearsIndividual variationRodent studiesAbuseAdultsSeeking behaviourDrug intakeEpidemiological evidenceSedative effects
2008
Subjective alcohol effects and drinking behavior: The relative influence of early response and acquired tolerance
Morean M, Corbin W. Subjective alcohol effects and drinking behavior: The relative influence of early response and acquired tolerance. Addictive Behaviors 2008, 33: 1306-1313. PMID: 18619740, DOI: 10.1016/j.addbeh.2008.06.007.Peer-Reviewed Original ResearchConceptsSubjective alcohol responsesRutgers Alcohol Problem IndexDrinking outcomesDrinking behaviorPredictive of drinking outcomesAssess alcohol useIncremental validityAlcohol responsesAlcohol effectsQuestionnaire-RevisedSelf-ratingsSedative responsePsychometric propertiesSedative effectsAlcohol useInternal consistencyAcquired toleranceProblem IndexRevised versionAssociated with useUnique variablesDrinkingOnline surveyModified versionEarly response
2007
Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors
Trevisan L, Petrakis IL, Pittman B, Gueorguieva R, D’Souza D, Perry E, Limoncelli D, Krystal JH. Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors. Alcohol Clinical And Experimental Research 2007, 32: 36-42. PMID: 18028532, DOI: 10.1111/j.1530-0277.2007.00543.x.Peer-Reviewed Original ResearchConceptsCo-agonist siteHealthy human subjectsEthanol administrationD-cycloserineHigh-dose d-cycloserineAlcohol levelsReceptor functionPlacebo 4 hoursDouble-blind conditionsNMDA receptor functionNMDA glutamate receptorsMild sedative effectDoses of ethanolGlutamate receptor functionBreath alcohol levelsHuman subjectsVerbal fluencyGlycineB siteGroups of subjectsEthanol antagonismCombination of ethanolSedative effectsNMDA receptorsClinical significanceGlutamate receptors
2004
Sedation after spinal anesthesia in elderly patients: a preliminary observational study with the PSA-4000
Kurup V, Ramani R, Atanassoff PG. Sedation after spinal anesthesia in elderly patients: a preliminary observational study with the PSA-4000. Journal Canadien D'anesthésie 2004, 51: 562-565. PMID: 15197118, DOI: 10.1007/bf03018398.Peer-Reviewed Original ResearchConceptsOAA/S scorePatient State IndexSpinal anesthesiaSedative effectsObservational studyPre-existing neurological conditionsS scoresElderly patient populationReticular activating systemOAA/SPreliminary observational studyElderly patientsNon-parametric dataSedation scoreSpinal anestheticPatient populationPsychotropic medicationsAfferent inputAnesthetic agentsMaximum sedationNeurological conditionsUnsedated patientsSedationAnesthesiaOrthopedic surgery
1995
Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience
CHAPPELL P, RIDDLE M, SCAHILL L, LYNCH K, SCHULTZ R, ARNSTEN A, LECKMAN J, COHEN D. Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1140-1146. PMID: 7559307, DOI: 10.1097/00004583-199509000-00010.Peer-Reviewed Original ResearchConceptsYale Global Tic Severity ScaleAttention deficit hyperactivity disorderTourette syndromeContinuous Performance TestHyperactivity disorderOpen-label studyCommon side effectsSeverity of motorComorbid attention deficit hyperactivity disorderSafe alternative therapySignificant decreaseTic Severity ScalePreliminary clinical experienceMajority of subjectsConners' Parent Rating ScaleTransient sedationControlled TrialsAlternative therapiesSedative effectsGuanfacine treatmentPhonic ticsSeverity ScaleSide effectsStimulant medicationTic severity
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