2020
Targeted glycan degradation potentiates the anticancer immune response in vivo
Gray MA, Stanczak MA, Mantuano NR, Xiao H, Pijnenborg JFA, Malaker SA, Miller CL, Weidenbacher PA, Tanzo JT, Ahn G, Woods EC, Läubli H, Bertozzi CR. Targeted glycan degradation potentiates the anticancer immune response in vivo. Nature Chemical Biology 2020, 16: 1376-1384. PMID: 32807964, PMCID: PMC7727925, DOI: 10.1038/s41589-020-0622-x.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsAntibodies, MonoclonalB7-H1 AntigenCell Line, TumorHumansHydrolysisImmunoconjugatesImmunotherapyKiller Cells, NaturalMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutModels, MolecularMolecular Targeted TherapyNeuraminidasePolysaccharidesProgrammed Cell Death 1 ReceptorProtein BindingProtein Interaction Domains and MotifsProtein Structure, SecondaryReceptor, ErbB-2Sialic Acid Binding Immunoglobulin-like LectinsSurvival AnalysisT-LymphocytesConceptsImmune checkpoint inhibitor therapyTumor-infiltrating myeloid cellsCheckpoint inhibitor therapyImmune cell infiltrationPowerful treatment optionAnticancer immune responseSurvival of miceSyngeneic breast cancer modelImmune cell activationBreast cancer modelBreast cancer cellsCheckpoint therapyMost patientsInhibitor therapyPD-1Checkpoint receptorsImmune suppressionTreatment optionsCell infiltrationImmune responseMyeloid cellsCancer modelCell activationCertain cancersCancer typesReduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis
Chen W, Karhadkar TR, Ryu C, Herzog EL, Gomer RH. Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis. ImmunoHorizons 2020, 4: 352-362. PMID: 32576593, PMCID: PMC8500545, DOI: 10.4049/immunohorizons.2000043.Peer-Reviewed Original ResearchConceptsSerum amyloid PIPF patientsPulmonary fibrosisFibrocyte differentiationIL-10 accumulationAmyloid PEffects of SAPIdiopathic pulmonary fibrosis (IPF) pathogenesisPulmonary fibrosis pathogenesisIdiopathic pulmonary fibrosisBronchoalveolar lavage fluidSera of patientsHigh extracellular levelsPotential therapeutic targetDifferentiation of monocytesSialic acidIPF pathogenesisIL-10Scar-like tissueLavage fluidHealthy controlsFatal disorderFibrosis pathogenesisHuman PBMCsTherapeutic target
2019
Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography
Boutagy NE, Ravera S, Papademetris X, Onofrey JA, Zhuang ZW, Wu J, Feher A, Stacy MR, French BA, Annex BH, Carrasco N, Sinusas AJ. Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography. Circulation Cardiovascular Imaging 2019, 12: e009063. PMID: 31296047, PMCID: PMC6629470, DOI: 10.1161/circimaging.119.009063.Peer-Reviewed Original ResearchConceptsMicro-single photon emissionSingle photon emissionHindlimb ischemiaTomography/Tomography/Computed TomographyIschemic gastrocnemius muscleNIS inhibitor perchloratePeripheral artery diseaseSkeletal muscleUnilateral hindlimb ischemiaAdeno-Associated Virus Serotype 9Standardized uptake valueSodium/iodide symporterVivo quantificationVirus serotype 9Vivo validationNonischemic limbsArtery diseaseNonischemic muscleC57BL/6J miceMurine modelGastrocnemius muscleComputed tomographyIschemic conditionsRadiotracer uptake
2018
An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae
Ortigoza M, Blaser S, Zafar M, Hammond A, Weiser J. An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae. MBio 2018, 9: 10.1128/mbio.02359-18. PMID: 30563897, PMCID: PMC6299224, DOI: 10.1128/mbio.02359-18.Peer-Reviewed Original ResearchConceptsInfluenza A virusSusceptible to influenza A virusesInfluenza A virus transmissionInfant mouse modelUpper respiratory tractInfluenza A virus sheddingHumoral immunityMouse modelInfluenza A virus strainsTransmission of influenza A virusesAnimal modelsVirus strainsInfluenza virus strainsUpper respiratory tract floraGuinea pig modelAntagonizing transmissionAdult miceSusceptible recipientsA virusMarker of infectiousnessSialidase expressionPandemic potentialViral sheddingRespiratory tractPig model
2017
Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut
Lim B, Zimmermann M, Barry NA, Goodman AL. Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut. Cell 2017, 169: 547-558.e15. PMID: 28431252, PMCID: PMC5532740, DOI: 10.1016/j.cell.2017.03.045.Peer-Reviewed Original ResearchConceptsGene expressionModulate gene expressionAbsence of inducerCommunity assemblyAddition of inducerGenetic toolsInducible promoterGene productsExpression platformHost physiologyPromoter activityHuman commensalGenus BacteroidesSynthetic inducersGut anaerobesInducerSialidase activityExpressionNumerous aspectsGut microbiotaSialic acidGutPromoterValuable toolCommensalAs human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31
Hyun SW, Liu A, Liu Z, Lillehoj EP, Madri JA, Reynolds AB, Goldblum SE. As human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31. Cellular Signalling 2017, 35: 1-15. PMID: 28343945, DOI: 10.1016/j.cellsig.2017.03.014.Peer-Reviewed Original ResearchMeSH KeywordsCateninsCell LineCell-Free SystemDelta CateninEndothelial CellsHumansLungMicrovesselsN-Acetylneuraminic AcidNeovascularization, PhysiologicNeuraminidasePhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Protein BindingProtein Interaction MapsProto-Oncogene Proteins c-fynProto-Oncogene Proteins c-yesSignal Transductionsrc-Family Kinases
2015
Nanomicroarray and Multiplex Next-Generation Sequencing for Simultaneous Identification and Characterization of Influenza Viruses - Volume 21, Number 3—March 2015 - Emerging Infectious Diseases journal - CDC
Zhao J, Ragupathy V, Liu J, Wang X, Vemula SV, Mubarak H, Ye Z, Landry ML, Hewlett I. Nanomicroarray and Multiplex Next-Generation Sequencing for Simultaneous Identification and Characterization of Influenza Viruses - Volume 21, Number 3—March 2015 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2015, 21: 400-408. PMID: 25694248, PMCID: PMC4344273, DOI: 10.3201/eid2103.141169.Peer-Reviewed Original ResearchConceptsMultiplex next-generation sequencingNext-generation sequencingInfluenza virusInfectious Diseases journal - CDCPotential influenza pandemicFuture epidemiologic studiesPublic health benefitsNew diagnostic algorithmInfluenza infectionB virusInfluenza AInfluenza pandemicEpidemiologic studiesMultiple influenzaLaboratory confirmationDiagnostic algorithmHealth benefitsNGS assaysVirusInfluenzaSubtypesMatrix genesGene segmentsDiagnostic platformConfirmation
2014
The Nogo Receptor NgR1 Mediates Infection by Mammalian Reovirus
Konopka-Anstadt JL, Mainou BA, Sutherland DM, Sekine Y, Strittmatter SM, Dermody TS. The Nogo Receptor NgR1 Mediates Infection by Mammalian Reovirus. Cell Host & Microbe 2014, 15: 681-691. PMID: 24922571, PMCID: PMC4100558, DOI: 10.1016/j.chom.2014.05.010.Peer-Reviewed Original ResearchConceptsCentral nervous systemReceptor NgR1Reovirus infectionExpression of NgR1Primary cortical neuronsDistinct cell surface moleculesJunctional adhesion molecule ASoluble NgR1Cell surface moleculesNeurotropic virusesCortical neuronsMammalian reovirusesNonsusceptible cellsNervous systemNgR1Null miceSystemic spreadInfectionIndependent receptorsMultiple receptorsReovirus replicationInitial siteReovirus virionsNeuronsReceptorsNeuraminidase inhibitors for influenza
Krumholz HM. Neuraminidase inhibitors for influenza. The BMJ 2014, 348: g2548. PMID: 24811413, DOI: 10.1136/bmj.g2548.Peer-Reviewed Original ResearchNEU1 Sialidase Regulates the Sialylation State of CD31 and Disrupts CD31-driven Capillary-like Tube Formation in Human Lung Microvascular Endothelia*
Lee C, Liu A, Miranda-Ribera A, Hyun SW, Lillehoj EP, Cross AS, Passaniti A, Grimm PR, Kim BY, Welling PA, Madri JA, DeLisser HM, Goldblum SE. NEU1 Sialidase Regulates the Sialylation State of CD31 and Disrupts CD31-driven Capillary-like Tube Formation in Human Lung Microvascular Endothelia*. Journal Of Biological Chemistry 2014, 289: 9121-9135. PMID: 24550400, PMCID: PMC3979388, DOI: 10.1074/jbc.m114.555888.Peer-Reviewed Original ResearchConceptsHuman pulmonary microvascular ECsCapillary-like tube formationEC tube formationTube formationCell adhesion molecule-1Pulmonary microvascular ECsHuman Lung Microvascular EndotheliaNeu1 sialidaseLung microvascular endotheliumAdhesion molecule-1Endothelial cell adhesion molecule-1Platelet endothelial cell adhesion molecule-1Endothelial cell expressionMultiplicity of infectionMicrovascular endotheliumMolecule-1Microvascular ECsCell expressionCD31Matrigel substrateSialylation statePeanut agglutinin lectinAdhesion moleculesInhibitory effectAngiogenic phenotype
2013
Ventriculomegaly associated with ependymal gliosis and declines in barrier integrity in the aging human and mouse brain
Shook BA, Lennington JB, Acabchuk RL, Halling M, Sun Y, Peters J, Wu Q, Mahajan A, Fellows DW, Conover JC. Ventriculomegaly associated with ependymal gliosis and declines in barrier integrity in the aging human and mouse brain. Aging Cell 2013, 13: 340-350. PMID: 24341850, PMCID: PMC3954884, DOI: 10.1111/acel.12184.Peer-Reviewed Original ResearchConceptsAged humansPeriventricular tissueVentricle enlargementGlial scarringEpendymal cell lossEpendymal cell liningPeriventricular gliosisReactive gliosisHistological featuresDegenerative lossLateral ventricleGliosisMouse modelVentricular expansionVentricle liningAquaporin-4Barrier integrityEpendymal cellsLateral ventricle surfaceCell lossMouse brainVentriculomegalyCell liningMiceScarring
2006
Variation in the Presence of Neuraminidase Genes among Streptococcus pneumoniae Isolates with Identical Sequence Types
Pettigrew MM, Fennie KP, York MP, Daniels J, Ghaffar F. Variation in the Presence of Neuraminidase Genes among Streptococcus pneumoniae Isolates with Identical Sequence Types. Infection And Immunity 2006, 74: 3360-3365. PMID: 16714565, PMCID: PMC1479257, DOI: 10.1128/iai.01442-05.Peer-Reviewed Original ResearchConceptsPneumoniae isolatesSequence typesUpper respiratory tractNeuraminidase geneS. pneumoniae isolatesVirulence determinantsStreptococcus pneumoniae isolatesIdentical sequence typesYoung childrenAdditional virulence determinantsSialic acid-containing substratesCapsule typesMultilocus sequence typesOtitis mediaInvasive diseaseRespiratory tractCarriage isolatesPneumococcal clonesSame sequence typePneumococcal strainsImportant causeStreptococcus pneumoniaeMiddle earDifferent tissue sourcesPneumococcal neuraminidase
2003
Murine neutrophils require α1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum
Carlyon JA, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings RD, McEver RP, Fikrig E. Murine neutrophils require α1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood 2003, 102: 3387-3395. PMID: 12869507, DOI: 10.1182/blood-2003-02-0621.Peer-Reviewed Original ResearchConceptsWild-type miceP-selectin glycoprotein ligand-1Murine neutrophilsCommon tick-borne diseaseAnaplasma phagocytophilumFuc-TIVHuman granulocytic ehrlichiosisPSGL-1 expressionTick-borne diseaseNeutrophil expressionInfection burdenMurine infectionNeutrophilsGranulocytic ehrlichiosisPhagocytophilum infectionMiceHuman neutrophilsSimilar molecular featuresInfectionProductive infectionSialidase treatmentLigand 1PhagocytophilumMolecular featuresFuc-TVII
2001
Glycosylation Alters Steady-State Inactivation of Sodium Channel Nav1.9/NaN in Dorsal Root Ganglion Neurons and Is Developmentally Regulated
Tyrrell L, Renganathan M, Dib-Hajj S, Waxman S. Glycosylation Alters Steady-State Inactivation of Sodium Channel Nav1.9/NaN in Dorsal Root Ganglion Neurons and Is Developmentally Regulated. Journal Of Neuroscience 2001, 21: 9629-9637. PMID: 11739573, PMCID: PMC6763018, DOI: 10.1523/jneurosci.21-24-09629.2001.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornAntibody SpecificityAxotomyCell MembraneCells, CulturedFemaleGanglia, SpinalGlycosylationImmunoblottingMembrane PotentialsN-Acetylneuraminic AcidNAV1.9 Voltage-Gated Sodium ChannelNeuraminidaseNeuronsNeuropeptidesPatch-Clamp TechniquesRatsRats, Sprague-DawleySciatic NerveSodiumSodium ChannelsSubcellular FractionsTetrodotoxinTrigeminal GanglionConceptsImmunoreactive proteinMembrane fractionAdult DRG neuronsTranscription-PCR analysisHigh molecular weight immunoreactive proteinTheoretical molecular weightWhole-cell patch-clamp analysisLong transcriptsGlycosylation statePatch-clamp analysisAdult tissuesLarge proteinsLimited glycosylationEnzymatic deglycosylationExtensive glycosylationState of glycosylationProteinAdult dorsal root gangliaGlycosylationNative neuronsDevelopmental changesInactivationMembrane preparationsDRG neuronsDorsal root gangliaCD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation
Daniels M, Devine L, Miller J, Moser J, Lukacher A, Altman J, Kavathas P, Hogquist K, Jameson S. CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation. Immunity 2001, 15: 1051-1061. PMID: 11754824, DOI: 10.1016/s1074-7613(01)00252-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 2ATP-Binding Cassette TransportersCD3 ComplexCD4-Positive T-LymphocytesCD8 AntigensCD8-Positive T-LymphocytesCell AdhesionCell DifferentiationCellular SenescenceGlycosylationH-2 AntigensHistocompatibility Antigen H-2DLigandsMacromolecular SubstancesMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutN-Acetylneuraminic AcidNeuraminidaseOvalbuminPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalReceptors, Antigen, T-Cell, alpha-betaRheologySolubilityT-Lymphocyte SubsetsThymus GlandConceptsGlycosylation stateT cell maturationCell maturationT cell adhesionDevelopmental regulationDouble-positive thymocytesCell adhesionT cell activationClass I MHC tetramersAdhesion moleculesCell activationMHC class I moleculesMaturationClass I moleculesClass I MHC moleculesI MHC moleculesI moleculesMoleculesGlycosylationMHC ligandsRegulationMHC moleculesClass I MHCBindingSialylation
1997
High-efficiency incorporation of functional influenza virus glycoproteins into recombinant vesicular stomatitis viruses
Kretzschmar E, Buonocore L, Schnell M, Rose J. High-efficiency incorporation of functional influenza virus glycoproteins into recombinant vesicular stomatitis viruses. Journal Of Virology 1997, 71: 5982-5989. PMID: 9223488, PMCID: PMC191854, DOI: 10.1128/jvi.71.8.5982-5989.1997.Peer-Reviewed Original ResearchConceptsVSV G proteinVesicular stomatitis virusG proteinsForeign membrane proteinsForeign proteinsVirus membrane glycoproteinsVSV particlesVSV G geneNA proteinsStomatitis virusGene orderExtra genesVSV transcriptionMembrane proteinsRecombinant vesicular stomatitis virusSite upstreamVSV virionsVSV membraneHA proteinInfluenza virus proteinsInfluenza virus glycoproteinsGlycoprotein geneGlycoprotein CD4Membrane glycoproteinsViral genomeIsolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin
Goetz D, Greif D, Ding H, Camphausen R, Howes S, Comess K, Snapp K, Kansas G, Luscinskas F. Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin. Journal Of Cell Biology 1997, 137: 509-519. PMID: 9128259, PMCID: PMC2139768, DOI: 10.1083/jcb.137.2.509.Peer-Reviewed Original ResearchAnimalsCell AdhesionCHO CellsCricetinaeE-SelectinEndothelium, VascularHumansImmunoglobulin Fc FragmentsLigandsMembrane GlycoproteinsMetalloendopeptidasesMicrospheresNeuraminidaseOligosaccharidesP-SelectinRecombinant Fusion ProteinsSialyl Lewis X AntigenThreonineTumor Necrosis Factor-alphaUmbilical Veins
1996
Membrane Association of Influenza Virus Matrix Protein Does Not Require Specific Hydrophobic Domains or the Viral Glycoproteins
KRETZSCHMAR E, BUI M, ROSE J. Membrane Association of Influenza Virus Matrix Protein Does Not Require Specific Hydrophobic Domains or the Viral Glycoproteins. Virology 1996, 220: 37-45. PMID: 8659126, DOI: 10.1006/viro.1996.0283.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBinding SitesCell LineCell MembraneChick EmbryoDogsHeLa CellsHemagglutinin Glycoproteins, Influenza VirusHemagglutinins, ViralHumansInfluenza A virusMolecular Sequence DataMutagenesis, Site-DirectedNeuraminidaseOligodeoxyribonucleotidesRecombinant ProteinsViral Matrix ProteinsConceptsMembrane associationSpecific hydrophobic domainsM1 proteinMatrix proteinsHydrophobic domainInfluenza virus matrix proteinVirus matrix proteinInteraction of M1Viral glycoproteinsMajor structural componentRibonucleocapsid coreCytoplasmic tailIntegral proteinsMembrane proteinsMembrane bindingSubcellular fractionationMembrane envelopeCellular membranesHeLa cellsViral proteinsHydrophobic regionProteinIsolated membranesMembraneInfluenza proteins
1981
Adjuvant Immunotherapy or Chemotherapy for Malignant Melanoma: Preliminary Report of the National Cancer Institute Randomized Clinical Trial
Fisher R, Terry W, Hodes R, Rosenberg S, Makuch R, Gordon H, Fisher S. Adjuvant Immunotherapy or Chemotherapy for Malignant Melanoma: Preliminary Report of the National Cancer Institute Randomized Clinical Trial. 1981, 61: 1267-1277. PMID: 7031934, DOI: 10.1016/s0039-6109(16)42582-x.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinDisease-free intervalAdjuvant immunotherapyClinical trialsMalignant melanomaStage I malignant melanomaStage II melanomaSurvival of patientsNational Cancer InstituteOverall survivalPostsurgical patientsMethyl-CCNUCalmette-GuerinCancer InstituteMelanoma cellsMelanomaFurther treatmentPreliminary reportImmunotherapyChemotherapyPatientsTrialsSurvivalSignificant improvement
1978
Characteristics of the Fc Receptor Induced by Herpes Simplex Virus
Costa J, Yee C, Nakamura Y, Rabson A. Characteristics of the Fc Receptor Induced by Herpes Simplex Virus. Intervirology 1978, 10: 32-39. PMID: 75867, DOI: 10.1159/000148965.Peer-Reviewed Original Research
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