2022
Antiproliferative Effects of Olanzapine against MCF-7 Cells and Its Molecular Interactions with Survivin
Vedam V, Nuthalapati P, Ghanta M, David D, Vijayalakshmi M, Potla K, Mary Y. Antiproliferative Effects of Olanzapine against MCF-7 Cells and Its Molecular Interactions with Survivin. International Journal Of Nutrition Pharmacology Neurological Diseases 2022, 12: 72-78. DOI: 10.4103/ijnpnd.ijnpnd_82_21.Peer-Reviewed Original ResearchMCF-7 cells
2019
Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells
Warth B, Palermo A, Rattray NJW, Lee NV, Zhu Z, Hoang LT, Cai Y, Mazurek A, Dann S, VanArsdale T, Fantin VR, Shields D, Siuzdak G, Johnson CH. Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells. Metabolites 2019, 9: 7. PMID: 30609717, PMCID: PMC6359333, DOI: 10.3390/metabo9010007.Peer-Reviewed Original ResearchProgression-free survivalBreast cancer cell metabolismEstrogen receptor antagonistCyclin-dependent kinase 4Breast cancer cellsCancer cell metabolismCombination chemotherapyMCF-7 cellsReceptor antagonistCombination chemotherapeuticsSurvival advantageSelective metabolic pathwaysMetabolic disruptionCancer cellsMetabolic pathwaysKinase 4Cancer metabolismSelective inhibitorPalbociclibSame metabolic pathwayDrugsMetabolismTranscriptomic changesCell modelCell metabolism
2018
Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy
Warth B, Raffeiner P, Granados A, Huan T, Fang M, Forsberg EM, Benton HP, Goetz L, Johnson CH, Siuzdak G. Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy. Cell Chemical Biology 2018, 25: 291-300.e3. PMID: 29337187, PMCID: PMC5856613, DOI: 10.1016/j.chembiol.2017.12.010.Peer-Reviewed Original ResearchConceptsEffects of palbociclibPositive breast cancerUS FDA approvalGlobal metabolomics approachMCF-7 cellsCombination therapyBreast cancerEstrogen receptorMetabolic effectsPhytoestrogen genisteinFDA approvalModel xenoestrogenCellular metabolismCancer therapyFunctional assaysXenoestrogensPathway modificationTherapyMetabolomics approachCombination cancer therapyFatty acidsEstrogenic mycotoxin zearalenoneProliferation experimentsMetabolitesMetabolism
2017
p63 and p73 repress CXCR5 chemokine receptor gene expression in p53-deficient MCF-7 breast cancer cells during genotoxic stress
Mitkin N, Muratova A, Sharonov G, Korneev K, Sviriaeva E, Mazurov D, Schwartz A, Kuprash D. p63 and p73 repress CXCR5 chemokine receptor gene expression in p53-deficient MCF-7 breast cancer cells during genotoxic stress. Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2017, 1860: 1169-1178. PMID: 29107083, DOI: 10.1016/j.bbagrm.2017.10.003.Peer-Reviewed Original ResearchConceptsMCF-7 breast cancer cellsBreast cancer cellsP53 family membersCXCR5 expressionMCF-7 cellsGenotoxic stressChemokine receptor gene expressionTumor response to chemotherapyCancer cellsNFkB activationParental MCF-7 cellsResponse to chemotherapyReceptor gene expressionDNA alkylating agent methyl methanesulfonateAssociated with elevated expressionChemokine receptor genesGene expressionActivation of p53 tumor suppressorMCF-7P53 tumor suppressorSite-directed mutagenesisP53 family genesCRISPR/Cas9-mediated inactivationEffects of genotoxic stressP53 geneSalinomycin Induces Reactive Oxygen Species and Apoptosis in Aggressive Breast Cancer Cells as Mediated with Regulation of Autophagy
Kim K, Park K, Kim S, Yu S, Lee D, Kim Y, Noh K, YEUL J, Seo Y, Ahn S. Salinomycin Induces Reactive Oxygen Species and Apoptosis in Aggressive Breast Cancer Cells as Mediated with Regulation of Autophagy. Anticancer Research 2017, 37: 1747-1758. PMID: 28373437, DOI: 10.21873/anticanres.11507.Peer-Reviewed Original ResearchConceptsMDA-MB-231 cellsAggressive breast cancer cellsBreast cancer cellsCancer cellsReactive oxygen speciesBreast cancer cell linesROS productionMitochondrial membrane potentialScavenger of ROSInduces reactive oxygen speciesCancer cell linesCaspase-3/9 activityPropidium iodide stainingMCF-7 cellsOxygen speciesAcceleration of apoptosisAcridine orange stainingAutophagy inhibitionMonocarboxylic ionophoreChemotherapeutic drugsCancer treatmentMitochondrial dysfunctionIodide stainingRegulation of autophagyUnderlying mechanism
2016
Identification of candidate anti-cancer molecular mechanisms of compound kushen injection using functional genomics
Qu Z, Cui J, Harata-Lee Y, Aung TN, Feng Q, Raison JM, Kortschak RD, Adelson DL. Identification of candidate anti-cancer molecular mechanisms of compound kushen injection using functional genomics. Oncotarget 2016, 7: 66003-66019. PMID: 27602759, PMCID: PMC5323210, DOI: 10.18632/oncotarget.11788.Peer-Reviewed Original ResearchConceptsCompound Kushen InjectionAnti-cancer molecular mechanismMolecular mechanismsHigh-throughput Illumina RNA-Seq technologyIllumina RNA-Seq technologyMCF-7 cellsKushen InjectionRNA-seq technologyEffect of CKITranscriptome analysis methodsLong non-coding RNAsPlant secondary metabolitesNon-coding RNAsDifferential expression analysisCell proliferationGene differential expression analysisMCF-7 human breast cancer cell lineDe novo identificationHuman breast cancer cell linesMCF-7 cell proliferationBreast cancer cell linesDose-dependent fashionAnnexin V/propidium iodideTraditional Chinese medicine preparationP53-independent mechanism
2013
Confocal Raman data analysis enables identifying apoptosis of MCF-7 cells caused by anticancer drug paclitaxel
Salehi H, Middendorp E, Panayotov I, Dutilleul P, Vegh AG, Ramakrishnan S, Gergely C, Cuisinier F. Confocal Raman data analysis enables identifying apoptosis of MCF-7 cells caused by anticancer drug paclitaxel. Journal Of Biomedical Optics 2013, 18: 056010-056010. PMID: 23698321, DOI: 10.1117/1.jbo.18.5.056010.Peer-Reviewed Original ResearchDetection of apoptosis caused by anticancer drug paclitaxel in MCF-7 cells by confocal Raman microscopy
Salehi H, Middendorp E, Végh A, Ramakrishnan S, Gergely C, Cuisinier F. Detection of apoptosis caused by anticancer drug paclitaxel in MCF-7 cells by confocal Raman microscopy. Proceedings Of SPIE--the International Society For Optical Engineering 2013, 8594: 85940f-85940f-10. DOI: 10.1117/12.1000149.Peer-Reviewed Original Research
2012
P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells
Hwang M, Peddibhotla S, McHenry P, Chang P, Yochum Z, Park K, Sears J, Vargo-Gogola T. P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells. Cancers 2012, 4: 475-489. PMID: 22582143, PMCID: PMC3348653, DOI: 10.3390/cancers4020475.Peer-Reviewed Original ResearchChromosome segregationMicrotubule-kinetochore attachmentsDisruption of mitosisRegulator of mitosisDeficient MCF-7 cellsP190B Rho GTPaseCancer cellsMitotic defectsRho proteinsRho GTPasesRac GTPaseRho GTPaseRac activityKnockdown cellsCell cycle analysisDeficient cellsChemical inhibitionNovel roleMitosisP190BS transitionS phaseHeLa cellsAltered expressionMCF-7 cells
2011
MicroRNA 135 Regulates HOXA10 Expression in Endometriosis
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 Regulates HOXA10 Expression in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2011, 96: e1925-e1933. PMID: 21956427, PMCID: PMC3232619, DOI: 10.1210/jc.2011-1231.Peer-Reviewed Original ResearchConceptsEndometrium of womenHOXA10 expressionHOXA10 regulationB expressionProliferative phaseEndometrial stromal cellsUniversity Medical CenterRegulation of HOXA10Time of ovulationMicroRNA-135Endometrial biopsyEndometrial receptivityMCF-7 cellsEndometrial samplesMenstrual cycleLuteal phaseMedical CenterSex steroidsStudy interventionEndometriosisSecretory phaseHOXA10 mRNAMicroRNA-135aStromal cellsEndometriumLow doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial–mesenchymal transition
Zhang X, Li X, Zhang N, Yang Q, Moran MS. Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial–mesenchymal transition. Biochemical And Biophysical Research Communications 2011, 412: 188-192. PMID: 21810413, DOI: 10.1016/j.bbrc.2011.07.074.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionBreast cancer cellsMCF-7 cellsCancer cellsMCF-7 breast cancer cellsEpithelial differentiation markersBreast cancerEMT markersLow doseMesenchymal markersTherapeutic effectivenessTranswell assaysMolecular alterationsLow dosesMesenchymal transitionRT-PCRCell invasionEnhanced migrationDifferentiation markersLDIRInvasivenessMarkersCellsPhenotypic changesInvasion
2010
In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer
Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS. In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer. Discover Oncology 2010, 1: 146-155. PMID: 21761357, PMCID: PMC3140020, DOI: 10.1007/s12672-010-0015-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzhydryl CompoundsBlotting, WesternCarcinogensCell Line, TumorDiethylstilbestrolEndocrine DisruptorsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticFemaleGene ExpressionHistone-Lysine N-MethyltransferaseHumansMammary Neoplasms, ExperimentalMicePhenolsPolycomb Repressive Complex 2PregnancyPrenatal Exposure Delayed EffectsReverse Transcriptase Polymerase Chain ReactionConceptsUtero exposureMCF-7 cellsEZH2 expressionMammary tissueMammary glandBreast cancerBreast cancer riskEffects of BPAAdult mammary tissueEZH2 protein expressionPersistent epigenetic changesZeste homolog 2DES exposureFetal exposureEZH2 mRNA expressionBreast neoplasiaNeoplastic changesCancer riskBPA treatmentEndocrine-disrupting chemicalsAdult womenDevelopmental programmingMRNA expressionUteroMice
2009
Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells
Ruiz-Ramos R, López-Carrillo L, Albores A, Hernández-Ramírez RU, Cebrian ME. Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells. Toxicology And Applied Pharmacology 2009, 241: 269-274. PMID: 19766132, DOI: 10.1016/j.taap.2009.09.006.Peer-Reviewed Original ResearchConceptsC-Myc protein levelsProtein levelsC-MycInduction of genesMCF-7 cellsHigher DNA synthesis rateMTHFR protein levelsAlters cell cycleBreast epithelial cellsArsenite treatmentGrowth regulationMethylenetetrahydrofolate reductaseCell cycleC-Myc overexpressionFolate cycleDNA synthesis rateBrdU-stained cellsEffects of arsenicCell proliferationHuman populationSodium arseniteEpithelial cellsCell viabilityMT1/2Arsenite concentrationCancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis
Yi CH, Zheng T, Leaderer D, Hoffman A, Zhu Y. Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis. Cancer Letters 2009, 284: 149-156. PMID: 19457610, PMCID: PMC3182267, DOI: 10.1016/j.canlet.2009.04.017.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBasic Helix-Loop-Helix Transcription FactorsBreast NeoplasmsCell Line, TumorCell Transformation, NeoplasticChromatin ImmunoprecipitationCircadian RhythmFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksGenome-Wide Association StudyHumansNeoplasm ProteinsNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisRNA InterferenceRNA, Small InterferingTranscription, GeneticConceptsDirect transcriptional targetTranscriptional targetsCircadian genesGenome-wide mapping approachChip analysisGenome-wide ChIPCancer-related gene expressionCore circadian genesRelevant biological pathwaysTranscriptional profilesGene expressionReal-time PCR assaysBiological processesCell cycleBiological pathwaysNPAS2Biological involvementGenesHuman cancersMCF-7 cellsCancer developmentTumorigenesisPCR assaysCircadian rhythmTarget
2008
Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry
Paz MM, Ladwa S, Champeil E, Liu Y, Rockwell S, Boamah EK, Bargonetti J, Callahan J, Roach J, Tomasz M. Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry. Chemical Research In Toxicology 2008, 21: 2370-2378. PMID: 19053323, PMCID: PMC2630229, DOI: 10.1021/tx8002615.Peer-Reviewed Original ResearchConceptsBreast cancer cellsMitomycin CCancer cellsMCF-7 human breast cancer cellsEMT6 cellsEMT6 mouse mammary tumor cellsHuman breast cancer cellsMCF-7 breast cancer cellsMouse mammary tumor cellsMammary tumor cellsMCF-7 cellsHuman fibroblastsMitomycin C treatmentTumor cellsReductive metabolitesDecarbamoyl mitomycin CNormal human fibroblastsSwitching of G-protein Usage by the Calcium-sensing Receptor Reverses Its Effect on Parathyroid Hormone-related Protein Secretion in Normal Versus Malignant Breast Cells*
Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J. Switching of G-protein Usage by the Calcium-sensing Receptor Reverses Its Effect on Parathyroid Hormone-related Protein Secretion in Normal Versus Malignant Breast Cells*. Journal Of Biological Chemistry 2008, 283: 24435-24447. PMID: 18621740, PMCID: PMC2528989, DOI: 10.1074/jbc.m801738200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone NeoplasmsBreast NeoplasmsCell Line, TumorCyclic AMPCyclic AMP-Dependent Protein KinasesFemaleGTP-Binding Protein alpha SubunitsHumansHypercalcemiaLactationMammary Glands, AnimalMammary Neoplasms, AnimalMAP Kinase Signaling SystemMiceNeoplasm MetastasisNeoplasm ProteinsParathyroid Hormone-Related ProteinPregnancyReceptors, Calcium-SensingType C PhospholipasesConceptsG-protein usagePTHrP productionMammary epithelial cellsBreast cancer cellsBreast cellsMCF-7 cellsParathyroid hormone-related protein secretionParathyroid hormone-related proteinParathyroid hormone secretionCancer cellsMCF-7 human breast cancer cellsCalcium-sensing receptorHuman breast cancer cellsHormone-related proteinNormal mammary epithelial cellsRegulation of calciumMalignant breast cellsNormal breast cellsG protein-coupled receptorsG protein couplingBone metastasesPTHrP secretionHormone secretionBone metabolismBreast cancer
2004
Expression of sigma 1 receptor in human breast cancer
Wang B, Rouzier R, Albarracin C, Sahin A, Wagner P, Yang Y, Smith T, Bernstam F, Marcelo A, Hortobagyi G, Pusztai L. Expression of sigma 1 receptor in human breast cancer. Breast Cancer Research And Treatment 2004, 87: 205-214. PMID: 15528963, DOI: 10.1007/s10549-004-6590-0.Peer-Reviewed Original ResearchConceptsHuman breast cancerSigma-1 receptorBreast cancerS1R expressionNormal breastMDA-MBCell linesBenign breast diseaseEffect of chemotherapyEpithelial cell stainingNeoplastic breast epithelial cellsInvasive breast carcinomaBreast cancer cell linesNormal breast tissueDose-dependent inhibitionAdditive cytotoxic effectBreast epithelial cellsAdjuvant chemotherapyCancer cell linesDuctal hyperplasiaMCF-7 cellsPredictive factorsCancer patientsBreast diseaseSitu cancerHOXA10 Regulates p53 Expression and Matrigel Invasion in Human Breast Cancer Cells
Chu MC, Selam FB, Taylor HS. HOXA10 Regulates p53 Expression and Matrigel Invasion in Human Breast Cancer Cells. Cancer Biology & Therapy 2004, 3: 568-572. PMID: 15044858, DOI: 10.4161/cbt.3.6.848.Peer-Reviewed Original ResearchConceptsEstrogen receptor modulatorsBreast cancer cellsHOXA10 expressionReceptor modulatorsP53 expressionBreast cancer cell growthBT20 cellsCancer cellsEffects of estradiolNormal breast developmentHuman breast cancer cellsHOXA10 mRNA expressionCancer cell growthP53 protein expressionMechanism of actionHuman breast tissueMCF-7 cellsBreast cancerBreast developmentSemi-quantitative RT-PCRMatrigel invasionMRNA expressionBreast tissueEstradiolFunctional phenotype
2003
An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation.
Lu J, Pierron A, Ravid K. An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation. Cancer Research 2003, 63: 6413-23. PMID: 14559831.Peer-Reviewed Original ResearchConceptsEstrogen receptor alphaIB-MECAMCF-7 cellsReceptor alphaHuman breast cancer cell proliferationBreast cancer cell proliferationDifferent adenosine analoguesHuman breast cancer cell line MCF-7Overexpression of ERalphaBreast cancer cell line MCF-7Breast cancer treatmentCancer cell line MCF-7Adenosine analoguesHs578T cellsCancer cell proliferationCell line MCF-7Breast cancer cell typesDifferent breast cancer cell typesCancer cell typesT cellsDrug treatmentN-methyluronamideSelective agonistZR-75Positive cells
1983
Tamoxifen and 5-fluorouracil in breast cancer: cytotoxic synergism in vitro.
Benz C, Cadman E, Gwin J, Wu T, Amara J, Eisenfeld A, Dannies P. Tamoxifen and 5-fluorouracil in breast cancer: cytotoxic synergism in vitro. Cancer Research 1983, 43: 5298-303. PMID: 6616464.Peer-Reviewed Original ResearchConceptsHormone-dependent human breast cancer cell linesCytotoxic interactionNuclear estrogen receptor levelsEstrogen receptor levelsHuman breast cancer cell linesBreast cancer cell linesMCF-7Nuclear estrogen receptorsMCF-7 cytotoxicityCytosol progesterone receptorGrowth inhibitionCytosol progesteroneCancer cell linesMCF-7 cellsMicroM tamoxifenProgesterone receptorBreast cancerReceptor levelsEstrogen receptorNM estradiolTamoxifenIsobologram analysisClonogenic assayControl valuesCell lines
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