2024
Performance of Ulcer Features in Predicting Malignancy Among Gastric Ulcers Diagnosed on Upper Endoscopy.
Patel A, Gandle C, Baerman E, Lill I, Pecha R, Nguyen Wenker T, El-Serag H, Ketwaroo G, Tan M. Performance of Ulcer Features in Predicting Malignancy Among Gastric Ulcers Diagnosed on Upper Endoscopy. Journal Of Clinical Gastroenterology 2024 PMID: 39761160, PMCID: PMC12203138, DOI: 10.1097/mcg.0000000000002118.Peer-Reviewed Original ResearchSurveillance endoscopyGastric atrophyIrregular bordersElevated borderGastric ulcerMalignant ulcersUlcer featuresGastric ulcer diagnosisPrevalence of malignancyPredictors of malignancyBenign gastric ulcerBiopsy histopathologyForrest classificationUpper endoscopyPredicting malignancyUlcer diagnosisMalignant featuresEndoscopic appearanceMalignancyPrevalent malignancyEndoscopyBenign ulcerPatientsPredictive valueHistopathology
2022
Identifying the profile of Helicobacter pylori negative gastric cancers: a case only analysis within the Stomach cancer Pooling (StoP) Project
Morais S, Peleteiro B, Araújo N, Malekzadeh R, Ye W, Plymoth A, Tsugane S, Hidaka A, Hamada GS, López-Carrillo L, Zaridze D, Maximovich D, Aragonés N, Castaño-Vinyals G, Pakseresht M, Hernández-Ramírez RU, López-Cervantes M, Leja M, Gasenko E, Pourfarzi F, Zhang ZF, Yu GP, Derakhshan MH, Pelucchi C, Negri E, La Vecchia C, Lunet N. Identifying the profile of Helicobacter pylori negative gastric cancers: a case only analysis within the Stomach cancer Pooling (StoP) Project. Cancer Epidemiology Biomarkers & Prevention 2022, 31: cebp.0402.2021. PMID: 34728467, DOI: 10.1158/1055-9965.epi-21-0402.Peer-Reviewed Original ResearchConceptsStomach cancer Pooling (StoP) ProjectGastric cancerNegative gastric cancerGastric atrophyRisk factorsOdds ratioFamily historyPooling ProjectPositive casesGastric cancer risk factorsInfection statusNon-cardia gastric cancerCancer risk factorsFirst-degree relativesHigh-risk profileAbsence of infectionOccurrence of cancerCurrent smokersPooled prevalenceCagA statusHpNGCSerologic testsLow prevalenceAdvanced stageCancer
2019
Sex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project)
Ferro A, Morais S, Pelucchi C, Dierssen-Sotos T, Martín V, López-Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernández-Ramírez RU, López-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Sex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project). European Journal Of Gastroenterology & Hepatology 2019, 31: 593-598. PMID: 30839435, DOI: 10.1097/meg.0000000000001389.Peer-Reviewed Original ResearchConceptsH. pylori infectionHelicobacter pylori infectionPylori infectionPrevalence ratiosOdds ratioGastric atrophyIgG serum antibody titersStomach cancer Pooling (StoP) ProjectPublication biasInfection statusSerum antibody titersConfidence intervalsSummary odds ratiosSerum pepsinogen levelsIndividual participant dataLifetime infectionsMultiplex serologyAntibody titersHistological examinationPooling ProjectPepsinogen levelsOlder controlsInfectionParticipant dataStrong association
2018
Gastric Adenocarcinoma of the Fundic Gland Type
Benedict MA, Lauwers GY, Jain D. Gastric Adenocarcinoma of the Fundic Gland Type. American Journal Of Clinical Pathology 2018, 149: 461-473. PMID: 29648578, DOI: 10.1093/ajcp/aqy019.Peer-Reviewed Original ResearchConceptsFundic gland typeGA-FGGastric adenocarcinomaParietal cellsEndoscopic mucosal resectionGeneral surgical pathologistsFeatures of malignancyChief cell differentiationGland typeDeeper invasionExtragastric spreadGastric atrophyLymphovascular invasionBenign courseIntestinal metaplasiaMucosal resectionNodal metastasisSurgical excisionChronic gastritisRare lesionsUncommon neoplasmHelicobacter infectionOxyntic mucosaSurgical pathologistsAdequate treatment
2010
Genetic Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals
Lochhead P, Frank B, Hold GL, Rabkin CS, Ng MT, Vaughan TL, Risch HA, Gammon MD, Lissowska J, Weck MN, Raum E, Müller H, Illig T, Klopp N, Dawson A, McColl KE, Brenner H, Chow W, El–Omar E. Genetic Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals. Gastroenterology 2010, 140: 435-441. PMID: 21070776, PMCID: PMC3031760, DOI: 10.1053/j.gastro.2010.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAntigens, NeoplasmCarcinoma, Squamous CellCase-Control StudiesEsophageal NeoplasmsFemaleGastritis, AtrophicGastrointestinal NeoplasmsGenetic Predisposition to DiseaseGPI-Linked ProteinsHelicobacter InfectionsHelicobacter pyloriHumansMaleNeoplasm ProteinsPolymorphism, Single NucleotideRiskWhite PeopleConceptsChronic atrophic gastritisNoncardia gastric cancerUpper gastrointestinal cancerGastric cancer casesProstate stem cell antigen (PSCA) geneCancer casesGastric cancerAtrophic gastritisGastrointestinal cancerRs2294008 polymorphismWhite individualsRisk allelesHelicobacter pylori-infected subjectsPylori-infected subjectsPopulation-based studySquamous cell carcinomaGastric cancer patientsGastric cardia cancerCase-control studyEsophageal cancer casesDiffuse histologic typeAntigen geneProximal cancersGastric atrophyHistologic type
2006
A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors
Hold GL, Rabkin CS, Chow W, Smith MG, Gammon MD, Risch HA, Vaughan TL, McColl KE, Lissowska J, Zatonski W, Schoenberg JB, Blot WJ, Mowat NA, Fraumeni JF, El–Omar E. A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors. Gastroenterology 2006, 132: 905-912. PMID: 17324405, DOI: 10.1053/j.gastro.2006.12.026.Peer-Reviewed Original ResearchMeSH KeywordsAchlorhydriaCarcinomaCase-Control StudiesCohort StudiesEuropeFemaleGastritis, AtrophicGene Expression Regulation, NeoplasticGene FrequencyGenetic Predisposition to DiseaseGenotypeHelicobacter InfectionsHelicobacter pyloriHumansLogistic ModelsMaleOdds RatioPhenotypePolymorphism, GeneticPopulation SurveillancePrecancerous ConditionsRegistriesRisk AssessmentRisk FactorsStomach NeoplasmsToll-Like Receptor 4United StatesConceptsH pylori infectionGastric carcinoma patientsNoncardia gastric carcinomaOdds ratioGastric carcinomaCardia carcinomaGastric atrophyCarcinoma patientsPylori infectionG polymorphismPopulation-based case-control studyUpper gastrointestinal tract cancerSevere gastric atrophyFrequency-matched controlsGastric acid outputGastrointestinal tract cancerGastric cancer patientsGastric cardia carcinomaCase-control studyEsophageal squamous cellsPotential confounding factorsGastric carcinoma casesGastric changesTract cancerAcid output
2003
Gastric Atrophy, Metaplasia, and Dysplasia
Kapadia CR. Gastric Atrophy, Metaplasia, and Dysplasia. Journal Of Clinical Gastroenterology 2003, 36: s29-s36. PMID: 12702963, DOI: 10.1097/00004836-200305001-00006.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisIntestinal metaplasiaAtrophic gastritisCobalamin deficiencyGastric atrophyPernicious anemiaPylori infectionDysplastic epitheliumH. pyloriFamilial Peutz-Jeghers syndromeChronic Helicobacter pylori infectionH. pylori-related gastritisSerum cobalamin levelsH. pylori infectionHelicobacter pylori infectionHigh-grade dysplasiaEarly gastric cancerExtent of atrophyRecent consensus conferenceFamilial adenomatous polyposis syndromeGastric adenomatous polypsAdenomatous polyposis syndromePeutz-Jeghers syndromeAutoimmune gastritisGastric remnant
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