2014
Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders
Rana A, Goyal N, Ahlawat A, Jamwal S, Reddy B, Sharma S. Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders. Perfusion 2014, 30: 94-105. PMID: 24947460, DOI: 10.1177/0267659114536760.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideIschemic preconditioningDiabetes mellitusMito-KATP channelMitochondrial permeability transition poreChronic diabetes mellitusGene-related peptideCardio-protective roleIschemia/reperfusionSub-lethal ischemiaGlycogen synthase kinase-3βSynthase kinase-3βCardioprotective effectsMyocardial damageMyocardial infarctionBlood supplyPart of heartMetabolic disordersInvolvement of PTENBeneficial effectsPTEN inhibitorKinase-3βPathological statesMellitusHyperlipidemia
2010
Renalase deficiency aggravates ischemic myocardial damage
Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. Renalase deficiency aggravates ischemic myocardial damage. Kidney International 2010, 79: 853-860. PMID: 21178975, DOI: 10.1038/ki.2010.488.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseWild-type miceRenalase deficiencyKnockout micePlasma blood urea nitrogenLevels of renalaseMild ventricular hypertrophyRenalase knockout mouseNormal systolic functionTraditional risk factorsPlasma catecholamine levelsIschemic myocardial damageBlood urea nitrogenCardiac complicationsCardiovascular complicationsSystolic functionVentricular hypertrophyCardioprotective effectsCatecholamine levelsKidney diseaseMyocardial damageMyocardial necrosisRecombinant renalaseRisk factorsCardiac ischemia
1999
Subxyphoid access of the normal pericardium: A novel drug delivery technique
Laham R, Simons M, Hung D. Subxyphoid access of the normal pericardium: A novel drug delivery technique. Catheterization And Cardiovascular Interventions 1999, 47: 109-111. PMID: 10385173, DOI: 10.1002/(sici)1522-726x(199905)47:1<109::aid-ccd24>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPericardial spaceHemodynamic compromiseNormal pericardiumSubxyphoid accessSmall pericardial effusionContinuous positive pressureNovel drug delivery techniqueIntrapericardial drug deliveryAnimals 4 weeksLarge animal modelDelivery techniquesNovel delivery techniquesAdverse eventsPericardial effusionMyocardial damageDrug delivery techniquesRight ventricleFluoroscopic guidanceInfusion catheterHistologic examinationPericardial accessIntroducer needlePositive pressureHigh riskAnimal models
1989
The Role of Nuclear Cardiology in the Assessment of Myocardial Infarction and the Evaluation of Early Interventions
Kayden D, Wackers F, Zaret B. The Role of Nuclear Cardiology in the Assessment of Myocardial Infarction and the Evaluation of Early Interventions. Developments In Cardiovascular Medicine 1989, 97: 187-211. DOI: 10.1007/978-1-4613-1597-1_10.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseConvalescent phaseMyocardial infarctionStable coronary artery diseaseManagement of patientsPresence of ischemiaMyocardial functional reserveNuclear cardiologyEarly reperfusionAcute phaseVentricular functionIschemic myocardiumMyocardial damageFunctional reservePatient prognosisEarly interventionInfarctionMyocardiumPrognosisInfarctsFuture riskPatientsDiagnostic toolAppropriate management strategies
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