2023
Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Zhang W, Zhao X, Qi X, Kimber S, Hooper N, Wang T. Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Frontiers In Cellular Neuroscience 2023, 17: 1195470. PMID: 37361999, PMCID: PMC10285224, DOI: 10.3389/fncel.2023.1195470.Peer-Reviewed Original ResearchBrain microvascular endothelial-like cellsTransendothelial electrical resistanceCerebral autosomal dominant arteriopathyAutosomal dominant arteriopathyCADASIL patientsNeurovascular interactionsMural cellsNeurovascular unitSubcortical infarctsBlood-brain barrier functionPluripotent stem cell modelsBarrier functionBrain MRI lesionsSmall vessel diseaseBrain barrier functionCortical projection neuronsStem cell modelWild-type astrocytesFuture therapeutic developmentNVU cell typesVascular mural cellsEarly disease pathologyInduced Pluripotent Stem Cell ModelRecurrent strokeCell types
2022
CGRP, Migraine, and Brain MRI in CADASIL
Goldstein E, Gopal N, Badi M, Hodge D, de Havenon A, Glover P, Durham P, Huang J, Lin M, Baradaran H, Majersik J, Meschia J. CGRP, Migraine, and Brain MRI in CADASIL. The Neurologist 2022, 28: 231-236. PMID: 36729391, PMCID: PMC10277309, DOI: 10.1097/nrl.0000000000000478.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideMigraine-related disabilitySerum calcitonin gene-related peptideSerum CGRP levelsCGRP levelsBrain magnetic resonance imagingCerebral autosomal dominant arteriopathyGene-related peptideAutosomal dominant arteriopathyMagnetic resonance imagingCross-sectional analysisRadiographic associationRadiographic implicationsPrimary outcomeT2 hyperintensityCerebral microbleedsDisability ScaleSubcortical infarctsMigraine pathophysiologyVasoactive peptidesBrain MRIMigraine pathologyMigraineResonance imagingCADASIL
2019
The Notch pathway in CNS homeostasis and neurodegeneration
Ho DM, Artavanis‐Tsakonas S, Louvi A. The Notch pathway in CNS homeostasis and neurodegeneration. WIREs Mechanisms Of Disease 2019, 9: e358. PMID: 31502763, DOI: 10.1002/wdev.358.Peer-Reviewed Original ResearchConceptsNervous system developmentCNS homeostasisNotch pathway activityNeurodegenerative diseasesCerebral autosomal dominant arteriopathyAcute brain traumaChronic neurodegenerative conditionsProgressive neurodegenerative diseaseAutosomal dominant arteriopathyCellular contextCentral nervous systemAmyotrophic lateral sclerosisNotch signalsAdult organismNotch activityNotch pathwayNeural developmentMultiple sclerosisAdult neurogenesisBrain traumaPathway activitySubcortical infarctsLateral sclerosisNOTCH3 mutationsHereditary stroke
2011
Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease
Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: e128-e135. PMID: 21555590, PMCID: PMC3102344, DOI: 10.1073/pnas.1101964108.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseIschemic cerebral small-vessel diseaseCerebral small vessel diseaseGranular osmiophilic materialMouse modelCerebral autosomal dominant arteriopathySmooth muscle cell degenerationBrain vessel pathologyPrevalent human conditionVascular smooth muscle cellsNotch 3 mutationPostmortem human tissueAutosomal dominant arteriopathyTransgenic mouse modelIschemic stroke susceptibilityAge-dependent phenotypeMuscle cell degenerationSmooth muscle cellsNotch-3 receptorCommon monogenic causeIschemic strokeVascular dementiaSubcortical infarctsReceptor activity assaysHuman brain vessels
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply