2025
Safety and immunogenicity of an adjuvanted chikungunya virus virus-like particle (CHIKV VLP) vaccine in previous recipients of other alphavirus vaccines versus alphavirus vaccine-naive controls: an open-label, parallel-group, age-matched, sex-matched, phase 2 randomised controlled study
Hamer M, McCarty J, Pierson B, Regules J, Mendy J, Sanborn A, Gardner C, Haller J, Gregory M, Liggett D, Glass P, Ghosh N, Royalty Tredo S, Warfield K, Burke C, Lee C, Saunders D, Bedell L, Richardson J. Safety and immunogenicity of an adjuvanted chikungunya virus virus-like particle (CHIKV VLP) vaccine in previous recipients of other alphavirus vaccines versus alphavirus vaccine-naive controls: an open-label, parallel-group, age-matched, sex-matched, phase 2 randomised controlled study. The Lancet Microbe 2025, 6: 101000. PMID: 39954701, DOI: 10.1016/j.lanmic.2024.101000.Peer-Reviewed Original ResearchGeometric mean titresCHIKV VLPsVaccine recipientsVLP vaccineAdverse eventsSex-matchedAlphavirus vaccinesOpen-labelParallel-groupAge-matchedVirus-like particlesPrimary immunogenicity endpointNeutralising antibodiesVEEV vaccinesAntibody seroconversion ratesPhase 2 randomised controlled trialFisher's exact testClinical study sitesStatistically significant differenceImmunogenicity endpointsSeroconversion ratesCompare immunogenicitySingle doseAntibody increaseExact test
2022
Serum Calcitonin Gene-Related Peptide Is Elevated in Patients With Migraine and Ophthalmoplegia
Takkar A, Kumar K, Katoch D, Singh P, Minz R, Anand S, Kathirvel S, Ravishankar K, Lal V, Caplan L. Serum Calcitonin Gene-Related Peptide Is Elevated in Patients With Migraine and Ophthalmoplegia. Journal Of Neuro-Ophthalmology 2022, 43: 399-405. PMID: 36255114, DOI: 10.1097/wno.0000000000001695.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideSerum CGRP levelsSerum calcitonin gene-related peptideCalcitonin gene-related peptide levelsCGRP levelsIctal phaseElevated serum CGRP levelsHeadaches consistent with migraineConsistent with migraineICHD-3 criteriaGene-related peptideSex-matched controlsSerum of patientsCase-control studyInflammatory neuropathiesICHD-3Episodic headacheInterictal phaseOphthalmoplegiaMigraineAge-matchedPatientsSerumHeadacheAbducens
2010
Incidence of Cytomegalovirus-associated thrombosis and its risk factors: A case-control study
Atzmony L, Halutz O, Avidor B, Finn T, Zimmerman O, Steinvil A, Zeltser D, Giladi M, Justo D. Incidence of Cytomegalovirus-associated thrombosis and its risk factors: A case-control study. Thrombosis Research 2010, 126: e439-e443. PMID: 20926120, DOI: 10.1016/j.thromres.2010.09.006.Peer-Reviewed Original ResearchConceptsAcute CMV infectionAssociated with thrombosisCMV infectionConsecutive patientsRisk factorsControl groupSex-matched consecutive patientsStudy groupCohort of patientsTertiary medical centerConsecutive matched patientsBinary logistic regression analysisLogistic regression analysisVenous thrombosesVenous thrombosisMatched patientsThrombosis incidenceInherited predispositionMedical chartsArterial thrombosisPhysician awarenessThrombosisAge-matchedPatientsMedical Center
2008
Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity
Anagnostopoulos C, Almonacid A, El Fakhri G, Curillova Z, Sitek A, Roughton M, Dorbala S, Popma J, Di Carli M. Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity. European Journal Of Nuclear Medicine And Molecular Imaging 2008, 35: 1593-1601. PMID: 18425513, PMCID: PMC3124702, DOI: 10.1007/s00259-008-0793-2.Peer-Reviewed Original ResearchConceptsPositron emission tomographyCoronary artery diseaseCoronary vasodilator reserveMyocardial blood flowPositron emission tomography imagingPercent diameter stenosisDiameter stenosisEmission tomographyAge-matchedStenosis severityHyperaemic myocardial blood flowRisk factorsStress myocardial blood flowVasodilator reserveFunctional assessment of coronary artery diseaseAssessment of coronary artery diseaseClinically useful tool
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