2024
Seven-tesla magnetic resonance imaging of the nervus terminalis, olfactory tracts, and olfactory bulbs in COVID-19 patients with anosmia and hypogeusia
Kirsch C, Khurram S, Lambert D, Belani P, Pawha P, Alipour A, Rashid S, Herb M, Saju S, Zhu Y, Delman B, Lin H, Balchandani P. Seven-tesla magnetic resonance imaging of the nervus terminalis, olfactory tracts, and olfactory bulbs in COVID-19 patients with anosmia and hypogeusia. Frontiers In Radiology 2024, 4: 1322851. PMID: 39410969, PMCID: PMC11473298, DOI: 10.3389/fradi.2024.1322851.Peer-Reviewed Original ResearchCOVID-19 patientsOlfactory bulbOlfactory tractNervus terminalisT2 hyperintensityAngiotensin-converting enzyme-2Olfactory nerveHealthy controlsSARS-CoV-2White matter T2 hyperintensitiesBoard-certified neuroradiologistsPotential entry sitesExpression of angiotensin-converting enzyme-2Viral entry siteBrain volume lossCentral nervous systemMagnetic resonance imagingBrainstem involvementT2 hyperintensitiesAbsence of NTOlfactory epitheliumVolume lossT2 signalACE-2 receptorHypogeusia
2022
CGRP, Migraine, and Brain MRI in CADASIL
Goldstein E, Gopal N, Badi M, Hodge D, de Havenon A, Glover P, Durham P, Huang J, Lin M, Baradaran H, Majersik J, Meschia J. CGRP, Migraine, and Brain MRI in CADASIL. The Neurologist 2022, 28: 231-236. PMID: 36729391, PMCID: PMC10277309, DOI: 10.1097/nrl.0000000000000478.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideMigraine-related disabilitySerum calcitonin gene-related peptideSerum CGRP levelsCGRP levelsBrain magnetic resonance imagingCerebral autosomal dominant arteriopathyGene-related peptideAutosomal dominant arteriopathyMagnetic resonance imagingCross-sectional analysisRadiographic associationRadiographic implicationsPrimary outcomeT2 hyperintensityCerebral microbleedsDisability ScaleSubcortical infarctsMigraine pathophysiologyVasoactive peptidesBrain MRIMigraine pathologyMigraineResonance imagingCADASIL
2021
Neuroinflammation Associated With Tumor Necrosis Factor-α Inhibitor Exposure
Yu AW, Pecsok M, Longbrake EE, Wesley SF. Neuroinflammation Associated With Tumor Necrosis Factor-α Inhibitor Exposure. Neurology Clinical Practice 2021, 11: e488-e496. PMID: 34484946, PMCID: PMC8382406, DOI: 10.1212/cpj.0000000000001014.Peer-Reviewed Original ResearchMRI findingsBrain MRIYale New Haven Health SystemNonspecific MRI findingsRetrospective cohort studyCommon abnormal findingDetailed chart reviewRisk stratification parametersElectronic medical recordsAdditional immunotherapyNeuroinflammatory phenomenaTNFi discontinuationTNFi exposureChart reviewCohort studyAbnormal findingsPeriod prevalenceT2 hyperintensityAutoimmune diseasesClinical spectrumInhibitor exposureMedical recordsTumor necrosisTNFiNeuroinflammation
2018
Severe Leukoencephalopathy with Clinical Recovery Caused by Recessive BOLA3 Mutations
Stutterd C, Lake N, Peters H, Lockhart P, Taft R, van der Knaap M, Vanderver A, Thorburn D, Simons C, Leventer R. Severe Leukoencephalopathy with Clinical Recovery Caused by Recessive BOLA3 Mutations. JIMD Reports 2018, 43: 63-70. PMID: 29654549, PMCID: PMC6323033, DOI: 10.1007/8904_2018_100.Peer-Reviewed Original ResearchComplete clinical recoveryClinical recoveryClinical courseMRI abnormalitiesWhite matterTrio whole-genome sequencingBilateral T2 hyperintensitiesWhole-genome sequencingPatient's clinical courseDeep white matterFrontal white matterCompound heterozygous variantsRespiratory chain enzyme activitiesNovel disease-causing variantsCultured patient fibroblastsPatient fibroblastsMitochondrial respiratory chain enzyme activitiesAcute hemiplegiaT2 hyperintensityMultisystem diseaseSevere leukoencephalopathyDisease onsetGenetic leukoencephalopathiesNeurological regressionLactate levels
2016
Rare case of T-cell lymphoma presenting as acute myelopathy
Samara VC, de Havenon A. Rare case of T-cell lymphoma presenting as acute myelopathy. BMJ Case Reports 2016, 2016: bcr2016217944. PMID: 27769981, PMCID: PMC5093351, DOI: 10.1136/bcr-2016-217944.Peer-Reviewed Original ResearchConceptsT-cell lymphomaAcute myelopathySystemic T-cell lymphomaT-cell lymphoproliferative disorderExtensive T2 hyperintensityLower extremity paresthesiasLower extremity weaknessDiffuse contrast enhancementErythematous maculopapular rashT lymphocyte populationsBone marrow aspirateExtremity weaknessSystemic chemotherapyExtremity paresthesiasMaculopapular rashLymphoproliferative disordersRare presentationT2 hyperintensityPeripheral bloodSpinal MRIMarrow aspiratesRare caseCerebrospinal fluidMyelopathyChemotherapy
2015
Multicontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes
Mossa-Basha M, Hwang WD, De Havenon A, Hippe D, Balu N, Becker KJ, Tirschwell DT, Hatsukami T, Anzai Y, Yuan C. Multicontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes. Stroke 2015, 46: 1567-1573. PMID: 25953365, DOI: 10.1161/strokeaha.115.009037.Peer-Reviewed Original ResearchConceptsReversible cerebral vasoconstriction syndromeVessel wall magnetic resonance imagingCerebral vasoconstriction syndromeMagnetic resonance imagingT2 hyperintensityIntracranial vasculopathyResonance imagingWall thickeningPattern of enhancementCases of atherosclerosisIntracranial vascular diseaseT2 signal characteristicsExcellent inter-reader agreementInter-reader agreementVasculitic lesionsInvasive workupWall involvementStenotic lesionsVasculopathic processPostcontrast enhancementVascular diseaseDifferential diagnosisVasculopathyLesion typeSyndrome
2014
Posterior reversible encephalopathy syndrome with spinal cord involvement
de Havenon A, Joos Z, Longenecker L, Shah L, Ansari S, Digre K. Posterior reversible encephalopathy syndrome with spinal cord involvement. Neurology 2014, 83: 2002-2006. PMID: 25355822, DOI: 10.1212/wnl.0000000000001026.Peer-Reviewed Original ResearchConceptsSpinal cord involvementReversible encephalopathy syndromeSpinal cord lesionsCord involvementEncephalopathy syndromeCord lesionsCervicomedullary junctionT2 hyperintensityHypertensive retinopathySpinal cordGrade IV hypertensive retinopathyReversible posterior leukoencephalopathy syndromeSpinal cord T2 hyperintensityCase of PRESPosterior leukoencephalopathy syndromeSevere acute hypertensionCohort of patientsFavorable clinical courseCervical spine MRIPatient management decisionsAcute hypertensionAntihypertensive treatmentHypertensive encephalopathyLeukoencephalopathy syndromeEmpiric treatmentA case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab
Fredericks C, Kvam K, Bear J, Crabtree G, Josephson. A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab. Lupus 2014, 23: 711-713. PMID: 24531080, DOI: 10.1177/0961203314524292.Peer-Reviewed Original ResearchConceptsProgressive multifocal leukoencephalopathySystemic lupus erythematosusMultifocal leukoencephalopathyAutoantibody-positive systemic lupus erythematosusDevelopment of PMLMild systemic lupus erythematosusTrials of belimumabProgressive neurologic declineFatal adverse effectsSoluble B lymphocyte stimulatorB lymphocyte stimulatorB cell maturationJCV PCRLupus patientsNeurologic declineSymptom onsetAutonomic symptomsLupus erythematosusT2 hyperintensityAutoimmune diseasesStandard treatmentBelimumabWhite matterEpisodic dystoniaCareful monitoring
2013
Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression.
Gupta R, Maralani P, Chawla S, Gopal P, Mohan S. Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression. Journal Of Neurosurgery 2013, 120: 522-7. PMID: 24329022, DOI: 10.3171/2013.11.jns13980.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Bacterial AgentsCerebellar DiseasesC-Reactive ProteinDecompression, SurgicalHumansImage Processing, Computer-AssistedImmunohistochemistryInfluenza VaccinesLeukocytosisMagnetic Resonance ImagingMaleNeuroimagingNeurosurgical ProceduresPseudotumor CerebriTomography, X-Ray ComputedVaccinationVentriculostomyConceptsPseudotumoral hemicerebellitisSurgical decompressionBilateral cerebellar hemispheresSignificant mass effectAcute cerebellitisT2 hyperintensityCerebellar swellingPediatric populationRare presentationSurgical interventionElderly malesInflammatory processPial enhancementAdvanced neuroimagingCerebellar hemisphereNeuroimaging findingsMR perfusionHemicerebellitisMR spectroscopyMass effectCerebellitisDecompressionMagnetic resonance
2001
Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits
Schaefer P, Gonzalez R, Hunter G, Wang B, Koroshetz W, Schwamm L. Diagnostic Value of Apparent Diffusion Coefficient Hyperintensity in Selected Patients With Acute Neurologic Deficits. Journal Of Neuroimaging 2001, 11: 369-380. PMID: 11677876, DOI: 10.1111/j.1552-6569.2001.tb00065.x.Peer-Reviewed Original ResearchConceptsAcute neurologic deficitsMagnetic resonance imagingDiffusion-weighted imagingNeurologic deficitsMRI abnormalitiesClinical syndromeMRI T2 hyperintensityVenous sinus thrombosisIschemic brain injuryEvaluation of patientsSubset of patientsConventional magnetic resonance imagingApparent diffusion coefficient (ADC) mapsDiffusion coefficient mapsHIV encephalopathyHypertensive encephalopathyNonischemic etiologyPosterior leukoencephalopathySinus thrombosisCarotid endarterectomyT2 hyperintensityNeurologic conditionsVasogenic edemaBrain injuryDiffusion magnetic resonance imaging
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