2024
Antibody gene features associated with binding and functional activity in malaria vaccine-derived human mAbs
Coelho C, Marquez S, Nguemwo Tentokam B, Berhe A, Miura K, Rao V, Long C, Doumbo O, Sagara I, Healy S, Kleinstein S, Duffy P. Antibody gene features associated with binding and functional activity in malaria vaccine-derived human mAbs. Npj Vaccines 2024, 9: 144. PMID: 39127706, PMCID: PMC11316794, DOI: 10.1038/s41541-024-00929-6.Peer-Reviewed Original ResearchHuman monoclonal antibodyBlocking parasite transmissionMalaria vaccinePlasmodium antigensImpact of adjuvantsClonotypic diversityHuman mAbsAS01Adjuvant groupVaccine designMalariaMonoclonal antibodiesAdjuvant selectionFunctional antibodiesAlhydrogelMAbGermline sequencesAntibodiesAntibody repertoireFunctional mAbsFunctional activityAdjuvantCohortIGHV1Vaccine
2023
Contrasting effects of molecular crowding on the membrane-perturbing and chaperone-like activities of major bovine seminal plasma protein, PDC-109
Singh B, Cheppali S, Saha I, Swamy M. Contrasting effects of molecular crowding on the membrane-perturbing and chaperone-like activities of major bovine seminal plasma protein, PDC-109. International Journal Of Biological Macromolecules 2023, 254: 127573. PMID: 37923045, DOI: 10.1016/j.ijbiomac.2023.127573.Peer-Reviewed Original ResearchConceptsChaperone-like activityPDC-109Effects of molecular crowdingMembrane destabilizationMolecular crowdingBovine seminal plasma proteinSperm cell surfaceSeminal plasma proteinsBovine seminal plasmaAcrosome reactionClient proteinsProtein stabilityMicroenvironment of proteinsSeminal plasmaMembrane-perturbingProtein oligomersReduced surface hydrophobicityOligomeric proteinsLipid effluxCell surfaceCrowding agentsProteinIsothermal titration calorimetric studiesTitration calorimetric studiesFunctional activity
2021
Psilocybin for the Treatment of Depression: A Promising New Pharmacotherapy Approach
Agin-Liebes G, Davis A. Psilocybin for the Treatment of Depression: A Promising New Pharmacotherapy Approach. Current Topics In Behavioral Neurosciences 2021, 56: 125-140. PMID: 34811715, PMCID: PMC10072288, DOI: 10.1007/7854_2021_282.Peer-Reviewed Original ResearchConceptsTreatment of depressionFunctional magnetic resonance imagingTreatment-resistant depressionDiscussion of study limitationsDepressive disorderPsilocybin therapyNeural regionsSerotonergic psychedelicsPharmacotherapy approachesNeuroimaging dataPsilocybinDepressionEffect sizeTherapeutic supportStudy limitationsMagnetic resonance imagingGlobal disabilityResonance imagingClinical trialsPsychedelicsFunctional activityNeuroimagingGlobal burdenDisordersDisabilityEvidence of hippocampal learning in human infants
Ellis CT, Skalaban LJ, Yates TS, Bejjanki VR, Córdova NI, Turk-Browne NB. Evidence of hippocampal learning in human infants. Current Biology 2021, 31: 3358-3364.e4. PMID: 34022155, DOI: 10.1016/j.cub.2021.04.072.Peer-Reviewed Original ResearchConceptsStatistical learningHuman infantsTask-based fMRIMedial prefrontal cortexHuman memoryVisual sequencesDurable memoriesMemory capacityMemory integrationAnterior hippocampusHippocampal activityPrefrontal cortexVital abilityTemporal orderHippocampal learningEarly childhoodLearningMemoryMonosynaptic pathwayTrisynaptic pathwayHippocampusInfantsYounger agePosterior divisionFunctional activity
2020
Risk Factors for Disability After Emergency Department Discharge in Older Adults
Nagurney JM, Han L, Leo‐Summers L, Allore HG, Gill TM. Risk Factors for Disability After Emergency Department Discharge in Older Adults. Academic Emergency Medicine 2020, 27: 1270-1278. PMID: 32673434, PMCID: PMC7749835, DOI: 10.1111/acem.14088.Peer-Reviewed Original ResearchConceptsLower extremity weaknessDisability burdenRisk factorsOlder adultsED visitsPhysical frailtyLongitudinal multivariable modelsEmergency department dischargeModifiable risk factorsCommunity-living personsCandidate risk factorsEmergency department experienceED dischargeNonmodifiable factorsMultivariable analysisRisk stratificationFunctional outcomeIndependent associationMultivariable modelOngoing longitudinal studyMonthly interviewsAnalytic sampleFunctional activityAdultsVisits
2019
Pain and activity after vaginal reconstructive surgery for pelvic organ prolapse and stress urinary incontinence
Barber M, Brubaker L, Nygaard I, Wai C, Dyer K, Ellington D, Sridhar A, Gantz M, Network N, Dickersin K, Jiang L, Lavender M, O’Dell K, Ryan K, Tulikangas P, Kong L, McClish D, Rickey L, Shade D, Tuteja A, Yount S. Pain and activity after vaginal reconstructive surgery for pelvic organ prolapse and stress urinary incontinence. American Journal Of Obstetrics And Gynecology 2019, 221: 233.e1-233.e16. PMID: 31201809, PMCID: PMC7250460, DOI: 10.1016/j.ajog.2019.06.004.Peer-Reviewed Original ResearchConceptsPelvic organ prolapseVaginal vault suspensionSacrospinous vaginal vault suspensionActivity Assessment ScaleMidurethral slingVault suspensionOrgan prolapseReconstructive surgeryPain medicationPostoperative painSurgical groupUrinary incontinenceBodily painFunctional activityPhysical functioningForm Health Survey bodily painBaseline levelsAssessment ScaleImmediate postoperative painNarcotic pain medicationNonnarcotic pain medicationRole-physical subscaleSurgical Pain ScalesSynthetic midurethral slingsTransvaginal prolapse repair
2018
The Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality A Longitudinal Study
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality A Longitudinal Study. CHEST Journal 2018, 153: 1378-1386. PMID: 29559308, PMCID: PMC6026287, DOI: 10.1016/j.chest.2018.03.007.Peer-Reviewed Original ResearchConceptsNursing home admissionPost-ICU disabilityHome admissionCritical illnessFrailty statusGreater disabilityNew nursing home admissionsAssociation of frailtyLikelihood of deathOne-point increaseICU admissionICU survivorsICU outcomesMean agePrognostic informationPrefrailtyFried indexAdmissionFrailtyOlder personsParent cohortAnalytic sampleFunctional activityNonfrailtyDisability
2016
Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 299-307. PMID: 26840348, PMCID: PMC4970594, DOI: 10.1164/rccm.201506-1256oc.Peer-Reviewed Original ResearchConceptsHigher Body Mass IndexOlder ICU survivorsIntensive care unitBody mass indexFunctional recoveryICU survivorsICU admissionMass indexOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsPoor functional recoveryCritical illnessIndependent predictorsCare unitMultivariable analysisFunctional outcomePremorbid functionPotential predictorsVision impairmentAdmissionSurvivorsAnalytic sampleFunctional activityMonths
2014
Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality
Shipitsin M, Small C, Giladi E, Siddiqui S, Choudhury S, Hussain S, Huang YE, Chang H, Rimm DL, Berman DM, Nifong TP, Blume-Jensen P. Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality. Proteome Science 2014, 12: 40. PMID: 25075204, PMCID: PMC4114438, DOI: 10.1186/1477-5956-12-40.Peer-Reviewed Original ResearchProtein levelsPost-translational modificationsProtein-based approachGene-based approachesIntact tissue specimensProtein activityProtein signaturesHuman prostate cancerMolecular informationPredictive protein biomarkersProtein biomarker levelsPhospho-PRAS40Phospho-S6Prostate cancer lethalityTissue lysisSPP1PTENIntact tissueSmad4Cancer lethalityPhenotypeCCND1Morphological featuresProtein biomarkersFunctional activity
2008
BAX activation is initiated at a novel interaction site
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng E, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature 2008, 455: 1076-1081. PMID: 18948948, PMCID: PMC2597110, DOI: 10.1038/nature07396.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisApoptosis Regulatory Proteinsbcl-2-Associated X ProteinBcl-2-Like Protein 11BH3 Interacting Domain Death Agonist ProteinCell LineGene Expression RegulationHumansMembrane ProteinsMiceMutagenesis, Site-DirectedMutationNuclear Magnetic Resonance, BiomolecularProtein BindingProto-Oncogene ProteinsSequence AlignmentConceptsAnti-apoptotic proteinsInteraction sitesBax activationBax-mediated cell deathBCL-2 domainsCell deathBcl-2 familyNovel interaction sitePro-apoptotic proteinsPoint mutagenesisMitochondrial apoptosisBax interactionStress stimuliΑ-helixProteinNew targetsBaxTherapeutic modulationDirect activationActivation siteApoptosisActivationFunctional activitySitesMutagenesis
2005
Role of PDZK1 in membrane expression of renal brush border ion exchangers
Thomson RB, Wang T, Thomson BR, Tarrats L, Girardi A, Mentone S, Soleimani M, Kocher O, Aronson PS. Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13331-13336. PMID: 16141316, PMCID: PMC1201624, DOI: 10.1073/pnas.0506578102.Peer-Reviewed Original ResearchConceptsProximal tubulesExpression of NHE3Functional activityRole of PDZK1Protein PDZK1Reabsorption of NaBrush border expressionMammalian kidneyCFEXBrush border localizationMutant miceGST fusion proteinProtein expressionKidneyBrush border membrane proteinsExchanger NHE3Membrane expressionNHE3Brush borderBrush border membrane vesiclesPDZK1 interactionTubulesNormal expressionMembrane proteinsPDZK1Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo
Lee A, Cerami A, Bucala R. Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo. 2005, 249-253. DOI: 10.1533/9781845698393.4.249.Peer-Reviewed Original ResearchEukaryotic model systemsMammalian systemsTransgenic embryosTransgenic miceSignificant genetic alterationsDNA mutationsDNA damageBiological integrityGenetic alterationsMaternal environmentMutation frequencyModel systemNucleic acidsMutationsVitroVivoFunctional activityLacI.Nonenzymatic glycosylationEmbryosGlycosylationLacI mutation frequencyDNAComparative analysisMice
2004
Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus
Swigut T, Alexander L, Morgan J, Lifson J, Mansfield K, Lang S, Johnson R, Skowronski J, Desrosiers R. Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus. Journal Of Virology 2004, 78: 13335-13344. PMID: 15542684, PMCID: PMC525019, DOI: 10.1128/jvi.78.23.13335-13344.2004.Peer-Reviewed Original ResearchConceptsSimian immunodeficiency virusHuman immunodeficiency virusImmunodeficiency virusWeeks postinfectionMajor Histocompatibility Complex Class I DownregulationClass IMajor histocompatibility complex class IHistocompatibility complex class IComplex class IMHC class INef gene productParental wild-type virusImmune responseLymphocyte activationWild-type virusNef functionCD4 downregulationFunctional activityMHC downregulationDownregulationResponse-4VirusMonkeysPostinfectionNef
2003
CD4+CD25+ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo
Baecher‐Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25+ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo. Novartis Foundation Symposia 2003, 252: 67-91. PMID: 14609213, DOI: 10.1002/0470871628.ch6.Peer-Reviewed Original ResearchConceptsT cellsRegulatory cellsPD-1/PD-L1 interactionLigand PD-L1Responder T cellsPD-L1 interactionContact-dependent mannerCo-culture assaysCTLA4 blockadeRegulatory populationPD-1PD-L1HLA-DRMultiple surface antigensCytokine secretionCD45RA expressionSurface antigenEx vivoLevel of expressionModest inductionSuppressive characteristicsFunctional activityHigh levelsCD25CD45RO
2000
Alterations in G-Proteins and β-Adrenergic Responsive Adenylyl Cyclase in Rat Urinary Bladder during Aging 1 1 This work was supported in part by National Institutes of Health Grant DK38311.
Derweesh I, Wheeler M, Weiss R. Alterations in G-Proteins and β-Adrenergic Responsive Adenylyl Cyclase in Rat Urinary Bladder during Aging 1 1 This work was supported in part by National Institutes of Health Grant DK38311. Journal Of Pharmacology And Experimental Therapeutics 2000, 294: 969-974. PMID: 10945848, DOI: 10.1016/s0022-3565(24)39160-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAdenylate Cyclase ToxinAdenylyl CyclasesAdrenergic beta-AgonistsAgingAnimalsBlotting, WesternCarbazolesColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsGTP-Binding ProteinsIndolesIsoproterenolMuscle, SmoothPertussis ToxinPyrrolesRatsReceptors, Adrenergic, betaUrinary BladderVirulence Factors, BordetellaConceptsPertussis toxin-catalyzed ADP-ribosylationToxin-catalyzed ADP-ribosylationRat bladderPertussis toxin-sensitive G proteinToxin-sensitive G proteinResponses of bladdersRat urinary bladderAdenylyl cyclaseTreatment of bladderBeta-adrenergic stimulationADP-ribosylationG proteinsAdenylyl cyclase activityResponsive adenylyl cyclaseAge-dependent declineWestern blot analysisG-protein contentUrinary bladderPertussis toxinBladderIsoproterenol stimulationRelaxation responseCyclase activityFunctional activityBlot analysis
1999
Functional activity of murine CD34+and CD34− hematopoietic stem cell populations
Donnelly D, Zelterman D, Sharkis S, Krause D. Functional activity of murine CD34+and CD34− hematopoietic stem cell populations. Experimental Hematology 1999, 27: 788-796. PMID: 10340393, DOI: 10.1016/s0301-472x(99)00032-6.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsCD34-LinStem cellsMurine bone marrow cellsHematopoietic stem cell populationStem cell populationCD34- hematopoietic stem cellsCompetitive repopulation experimentsHuman hematopoietic stem cellsClinical transplantation protocolsLong-term engraftmentBone marrowMarrow repopulating cellsBone marrow cellsDistinct populationsRepopulation experimentsRepopulating cellsCell populationsBone marrow repopulating cellsCD34 cellsMarrow cellsCell numberCellsFunctional activityBone marrow reconstitutionLessons from Knockout and Transgenic Lupus-Prone Mice
Peng S, Craft J. Lessons from Knockout and Transgenic Lupus-Prone Mice. Contemporary Immunology 1999, 152-166. DOI: 10.1007/978-1-59259-703-1_10.Peer-Reviewed Original ResearchLupus-prone miceSystemic lupus erythematosusNZB ×Disease manifestationsStudy of lupusLupus-like symptomsMRL/MpPathogenesis of lupusB cell toleranceLupus erythematosusImmune deficiencyT cellsImmune organsB cellsDisease pathogenesisImmune systemMurine systemMouse strainsMajority of knowledgeFunctional activityMiceGenetic alterationsLupusHuman disease pathogenesisPathogenesis
1998
Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity
Sibson N, Shen J, Mason G, Rothman D, Behar K, Shulman R. Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity. Developmental Neuroscience 1998, 20: 321-330. PMID: 9778568, DOI: 10.1159/000017327.Peer-Reviewed Original ResearchConceptsRat brain cortexGlucose metabolismBrain cortexNeurotransmitter cyclingTotal glucose oxidationGlutamatergic synaptic activityCerebral glucose consumptionCerebral glucose metabolismFunctional activityFunctional imaging methodsGlucose oxidationOxidative glucose metabolismGlutamate neurotransmitter cyclingSynaptic activityNeuronal activityMild anesthesiaGlutamine synthesisMammalian brainNeurotransmitter releaseGlutamate cyclingEEG activityAmmonia metabolismNeurophysiological basisDetoxification componentsVivo resultsFunctional and Molecular Characterization of Human Monoclonal Antibody Reactive with the Immunodominant Region of HIV Type 1 Glycoprotein 41
Cavacini L, Emes C, Wisnewski A, Power J, Lewis G, Montefiori D, Posner M. Functional and Molecular Characterization of Human Monoclonal Antibody Reactive with the Immunodominant Region of HIV Type 1 Glycoprotein 41. AIDS Research And Human Retroviruses 1998, 14: 1271-1280. PMID: 9764911, DOI: 10.1089/aid.1998.14.1271.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalBlotting, WesternCloning, MolecularComplement System ProteinsGenes, ImmunoglobulinHIV Envelope Protein gp120HIV Envelope Protein gp41HIV InfectionsHIV-1HumansImmunodominant EpitopesImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsMiceMolecular Sequence DataSequence Analysis, DNAConceptsHuman monoclonal antibodyHuman Monoclonal Antibody ReactiveHIV-1-infected individualsImmunodominant regionCD4-binding siteAntigen-driven responseComplement-dependent mannerHIV Type 1 Glycoprotein 41Presence of complementMonoclonal Antibodies ReactiveLaboratory isolatesSoluble CD4Nonprotective antibodiesPrecursor gp160Antibody reactiveAntigen specificityViral infectionGp41 regionExtensive somatic mutationCytometric analysisAntibody clonotypesMonoclonal antibodiesPepscan analysisUninfected cellsFunctional activityPhase I Study of a Human Monoclonal Antibody Directed against the CD4-Binding Site of HIV Type 1 Glycoprotein 120
Cavacini LA, Samore MH, Gambertoglio J, Jackson B, Duval M, Wisnewski A, Hammer S, Koziel C, Trapnell C, Posner MR. Phase I Study of a Human Monoclonal Antibody Directed against the CD4-Binding Site of HIV Type 1 Glycoprotein 120. AIDS Research And Human Retroviruses 1998, 14: 545-550. PMID: 9591708, DOI: 10.1089/aid.1998.14.545.Peer-Reviewed Original ResearchConceptsSingle doseHIV Type 1 Glycoprotein 120HIV-1-infected individualsHIV-1-infected cellsAnti-HIV-1 activityFunctional activityCD4-binding siteCD4 binding siteHuman monoclonal antibodyAbility of serumInfused antibodyQuantitative microcultureAntibody infusionEscalation studyFull functional activityGlycoprotein 120Primary isolatesHIV-1Immune responseSingle injectionGp120-CD4PatientsSite antibodiesCD4Spectrum of isolates
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