Alterations in G-Proteins and β-Adrenergic Responsive Adenylyl Cyclase in Rat Urinary Bladder during Aging 1 1 This work was supported in part by National Institutes of Health Grant DK38311.
Derweesh I, Wheeler M, Weiss R. Alterations in G-Proteins and β-Adrenergic Responsive Adenylyl Cyclase in Rat Urinary Bladder during Aging 1 1 This work was supported in part by National Institutes of Health Grant DK38311. Journal Of Pharmacology And Experimental Therapeutics 2000, 294: 969-974. PMID: 10945848, DOI: 10.1016/s0022-3565(24)39160-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAdenylate Cyclase ToxinAdenylyl CyclasesAdrenergic beta-AgonistsAgingAnimalsBlotting, WesternCarbazolesColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsGTP-Binding ProteinsIndolesIsoproterenolMuscle, SmoothPertussis ToxinPyrrolesRatsReceptors, Adrenergic, betaUrinary BladderVirulence Factors, BordetellaConceptsPertussis toxin-catalyzed ADP-ribosylationToxin-catalyzed ADP-ribosylationRat bladderPertussis toxin-sensitive G proteinToxin-sensitive G proteinResponses of bladdersRat urinary bladderAdenylyl cyclaseTreatment of bladderBeta-adrenergic stimulationADP-ribosylationG proteinsAdenylyl cyclase activityResponsive adenylyl cyclaseAge-dependent declineWestern blot analysisG-protein contentUrinary bladderPertussis toxinBladderIsoproterenol stimulationRelaxation responseCyclase activityFunctional activityBlot analysis
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