2023
Contrasting effects of molecular crowding on the membrane-perturbing and chaperone-like activities of major bovine seminal plasma protein, PDC-109
Singh B, Cheppali S, Saha I, Swamy M. Contrasting effects of molecular crowding on the membrane-perturbing and chaperone-like activities of major bovine seminal plasma protein, PDC-109. International Journal Of Biological Macromolecules 2023, 254: 127573. PMID: 37923045, DOI: 10.1016/j.ijbiomac.2023.127573.Peer-Reviewed Original ResearchConceptsChaperone-like activityPDC-109Effects of molecular crowdingMembrane destabilizationMolecular crowdingBovine seminal plasma proteinSperm cell surfaceSeminal plasma proteinsBovine seminal plasmaAcrosome reactionClient proteinsProtein stabilityMicroenvironment of proteinsSeminal plasmaMembrane-perturbingProtein oligomersReduced surface hydrophobicityOligomeric proteinsLipid effluxCell surfaceCrowding agentsProteinIsothermal titration calorimetric studiesTitration calorimetric studiesFunctional activity
2013
The common hereditary elliptocytosis-associated α-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation
Harper SL, Sriswasdi S, Tang HY, Gaetani M, Gallagher PG, Speicher DW. The common hereditary elliptocytosis-associated α-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation. Blood 2013, 122: 3045-3053. PMID: 23974198, PMCID: PMC3811177, DOI: 10.1182/blood-2013-02-487702.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBinding SitesCross-Linking ReagentsElliptocytosis, HereditaryErythrocyte MembraneHumansModels, MolecularMolecular Sequence DataMutationProtein BindingProtein MultimerizationProtein StabilityProtein Structure, SecondaryProtein Structure, TertiaryRecombinant ProteinsSpectrinConceptsHereditary elliptocytosisMembrane destabilizationLarge conformational rearrangementsGel filtration analysisMembrane proteinsTetramer assemblyHereditary pyropoikilocytosisBiophysical analysisCommon hereditary elliptocytosisConformational rearrangementsDimer conformationHelical contentTetramerization siteFiltration analysisSpectrin tetramersNovel mechanismUnknown mechanismMutationsBinding assaysSpectrinChemical crosslinkingErythrocyte shapeTetramerErythrocyte membranesMembrane
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