2021
BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, Xiang J, Yuan X, Sun B, Sisodia SS, Jiang YH, Cao X, Jing N, Lin A. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. IScience 2021, 24: 102942. PMID: 34430820, PMCID: PMC8369003, DOI: 10.1016/j.isci.2021.102942.Peer-Reviewed Original ResearchNeuronal apoptosisAlzheimer's diseaseMicroglial phagocytosisMicroglial NLRP3 inflammasome activationDisease pathologyCommon progressive neurodegenerative diseaseProgressive neurodegenerative diseaseAlzheimer's disease pathologyNLRP3 inflammasome activationPotential therapeutic targetNeuroinflammatory microgliaAD miceAβ clearanceAD pathologyBad pro-apoptotic activityAD patientsInflammasome activationTherapeutic targetMemory deficitsPro-apoptotic proteinsNeuroinflammationNeurodegenerative diseasesSpatial learningInactivation of BadPro-apoptotic activity
2019
SMAC mimetics as potential cancer therapeutics in myeloid malignancies
Boddu P, Carter BZ, Verstovsek S, Pemmaraju N. SMAC mimetics as potential cancer therapeutics in myeloid malignancies. British Journal Of Haematology 2019, 185: 219-231. PMID: 30836448, DOI: 10.1111/bjh.15829.Peer-Reviewed Original ResearchConceptsSmac mimeticsSmall-molecule Smac mimeticsSecond mitochondria-derived activatorEvasion of apoptosisPro-apoptotic proteinsPotential cancer therapeuticsMyeloid malignanciesIAP antagonismApoptosis proteinIAP expressionApoptosis thresholdDeath receptorsCaspase proteinsCell deathImmune check-point blockadeIAP activityReceptor tyrosine kinase inhibitorsCheck-point blockadeCancer therapeuticsEffect of chemotherapyDirect targetingProteinTumor necrosis factorFas ligandTyrosine kinase inhibitors
2010
A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma
Katz S, Labelle J, Godes M, Fisher J, Bird G, Walensky L. A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma. Blood 2010, 116: 437. DOI: 10.1182/blood.v116.21.437.437.Peer-Reviewed Original ResearchMantle cell lymphomaCell lymphomaAggressive B-cell lymphomasDevelopment of splenomegalyRAG2-deficient miceB-cell lymphomaLymphoproliferative diseaseOrgan infiltrationMCL cell linesConventional chemotherapyHematologic cancersAnti-apoptotic proteinsBone marrowNormal parenchymaVivo modelPro-apoptotic proteinsCell-permeable peptideLymphomaPro-apoptotic activityGenetic aberrationsMiceBcl-2TUNEL positivityPro-apoptotic Bcl-2 family protein BimCaspase-3/7
2008
Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis
Gavathiotis E, Suzuki M, Davis M, Pitter K, Bird G, Katz S, Tu H, Kim H, Cheng E, Tjandra N, Walensky L. Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis. Blood 2008, 112: 300. DOI: 10.1182/blood.v112.11.300.300.Peer-Reviewed Original ResearchAnti-apoptotic proteinsBax activationCell deathInteraction sitesAlpha-helixBCL-2 domainsBcl-2 family proteinsBcl-2 familyPathologic cell deathBax-mediated apoptosisFirst structural analysisPro-apoptotic proteinsDomain proteinsFamily proteinsMitochondrial translocationProtein interactionsPoint mutagenesisMitochondrial apoptosisStress stimuliBcl-xLConformational changesCell survivalMitochondrial dysfunctionNovel siteDistinct assaysBAX activation is initiated at a novel interaction site
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng E, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature 2008, 455: 1076-1081. PMID: 18948948, PMCID: PMC2597110, DOI: 10.1038/nature07396.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisApoptosis Regulatory Proteinsbcl-2-Associated X ProteinBcl-2-Like Protein 11BH3 Interacting Domain Death Agonist ProteinCell LineGene Expression RegulationHumansMembrane ProteinsMiceMutagenesis, Site-DirectedMutationNuclear Magnetic Resonance, BiomolecularProtein BindingProto-Oncogene ProteinsSequence AlignmentConceptsAnti-apoptotic proteinsInteraction sitesBax activationBax-mediated cell deathBCL-2 domainsCell deathBcl-2 familyNovel interaction sitePro-apoptotic proteinsPoint mutagenesisMitochondrial apoptosisBax interactionStress stimuliΑ-helixProteinNew targetsBaxTherapeutic modulationDirect activationActivation siteApoptosisActivationFunctional activitySitesMutagenesis
2007
Pharmacologic Replacement of BIM BH3 Reactivates Apoptosis in Hematologic Cancer and Lymphoproliferative Disease.
LaBelle J, Fisher J, Katz S, Bird G, Lawrence C, Silverstein A, Walensky L. Pharmacologic Replacement of BIM BH3 Reactivates Apoptosis in Hematologic Cancer and Lymphoproliferative Disease. Blood 2007, 110: 524. DOI: 10.1182/blood.v110.11.524.524.Peer-Reviewed Original ResearchAnti-apoptotic proteinsBim-/- miceBcl-2 family protein interactionsBCL-2 domainsBH3-only proteinsRegulation of apoptosisApoptotic signaling pathwaysPro-apoptotic proteinsPromising pharmacologic strategyAnti-apoptotic targetsCellular homeostasisBH3 domainProtein interactionsDeath pathwaysProtein networkCellular survivalSignaling pathwaysApoptotic blockadesCell deathSAHBLymphoma cell linesBH3Apoptosis inductionProteinMitochondrial damage
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply