2024
Maximizing Donor Egg Efficiency: Artificial Intelligence and Genetically Certified Oocytes
Aydin B, Hudkova D, Halicigil C. Maximizing Donor Egg Efficiency: Artificial Intelligence and Genetically Certified Oocytes. 2024, 471-490. DOI: 10.1007/978-3-031-58214-1_48.Peer-Reviewed Original ResearchDonor oocyte banksSelection of oocytesOocyte bankingOocyte vitrificationOocyte donationPGT-A methodsChances of implantationVitrification protocolPolar body biopsyUsable blastocystsEuploid blastocystsPGT-AAneuploid oocytesClinical pregnancyBody biopsyAneuploidy statusBiopsy methodClinical dataOncological problemSurvival rateOocytesPolar bodyPatientsMorphological evaluationMedical reasonsAddition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women
Esbert M, Tao X, Ballesteros A, Yildirim R, Scott R, Seli E. Addition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women. Molecular Human Reproduction 2024, 30: gaad048. PMID: 38180884, DOI: 10.1093/molehr/gaad048.Peer-Reviewed Original ResearchReproductive-age womenEuploidy rateCumulus cellsAutologous cumulus cellsAge womenReproductive ageRescue IVMOlder womenYoung donorsYoung reproductive age womenYoung womenOlder reproductive age womenOocyte maturationMetaphase II oocytesGerminal vesicle stage oocytesPolar bodyMaternal ageEuploid oocytesFirst polar bodyAddition of rapamycinHours of cultureII oocytesWomenCytogenetic constitutionRapamycin
2018
Assembly and Positioning of the Oocyte Meiotic Spindle
Mogessie B, Scheffler K, Schuh M. Assembly and Positioning of the Oocyte Meiotic Spindle. Annual Review Of Cell And Developmental Biology 2018, 34: 381-403. PMID: 30028643, DOI: 10.1146/annurev-cellbio-100616-060553.Peer-Reviewed Original Research
2015
Oocyte mitochondrial function and reproduction
Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Current Opinion In Obstetrics & Gynecology 2015, 27: 175-181. PMID: 25719756, PMCID: PMC4590773, DOI: 10.1097/gco.0000000000000164.Peer-Reviewed Original ResearchConceptsOocyte mitochondrial functionMitochondrial functionEmbryonic developmentMitochondrial nutrientsMitochondrial replacementRole of mitochondriaOogonial stem cellsCellular organellesMammalian reproductionMitochondrial performanceMitochondrial diseaseEmbryo developmentMitochondrial activityMitochondrial dysfunctionOocyte developmentMitochondriaReproductive consequencesStem cellsOocyte maturationMitochondrial abnormalitiesPolar bodyReproductionEnergy productionIntake of compoundsNegative long-term health effects
2013
Kinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells
Kidane D, Sakkas D, Nottoli T, McGrath J, Sweasy JB. Kinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells. PLOS ONE 2013, 8: e58585. PMID: 23560038, PMCID: PMC3613343, DOI: 10.1371/journal.pone.0058585.Peer-Reviewed Original ResearchConceptsMitotic cell divisionCell divisionKinesin 5BChromosomal segregationMitotic cellsCell developmentGerminal vesicle breakdownKnockdown of KIF5BProper chromosomal segregationChromosomal segregation defectsFemale meiosisSegregation defectsChromosomal stabilityRNA interferenceChromosomal instabilityFirst polar bodyMouse oocytesKIF5BMolecular motorsPolar bodyVesicle breakdownBirth defectsDivisionCellsMeiosis
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