2024
An Infant With DHX37 Variant: A Novel Etiology of 46,XY DSD and Literature Review
Yilmaz R, Hittelman A, Vash-Margita A, Dinauer C, Weinzimer S, Gujral J. An Infant With DHX37 Variant: A Novel Etiology of 46,XY DSD and Literature Review. JCEM Case Reports 2024, 3: luae239. PMID: 39726663, PMCID: PMC11669865, DOI: 10.1210/jcemcr/luae239.Peer-Reviewed Case Reports and Technical NotesAnti-Mullerian hormoneIntra-abdominal gonadsInhibin B levelsPrenatal ultrasound findingsElevated gonadotropin levelsRisk of malignancyHeterozygous pathogenic variantsGenotype-phenotype correlationNonpalpable gonadsGenital phenotypeLabioscrotal foldsFallopian tubeGonadotropin levelsClinical courseUrine retentionAtypical genitaliaUrogenital sinusVaginal openingCase reportSeparate uteriPathogenic variantsDEAH-boxRibosome biogenesisTestosterone levelsNovel etiology
2022
Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice.
Saleh FL, Joshi AA, Tal A, Xu P, Hens J, Wong SL, Flannery C. Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice. Journal Of Endocrinology 2022, 254: 121-135. PMID: 35904489, PMCID: PMC9837806, DOI: 10.1530/joe-21-0447.Peer-Reviewed Original ResearchConceptsVaginal openingInsulin resistanceDay of VOIGF-1 levelsInsulin-like growth factor 1 receptorGreater insulin resistanceHigher insulin levelsEffect of hyperinsulinemiaGrowth factor 1 receptorGonadotropin-releasing hormoneLower body weightFactor 1 receptorReceptor isoform expressionMammary gland developmentLH levelsInsulin levelsInsulin receptor isoform expressionKisspeptin expressionChildhood obesityFemale miceHormone levelsEarly initiationHyperinsulinemiaBody weightOvarian follicles
2018
Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty
SALEH F, TAYLOR H, FLANNERY C. Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty. Diabetes 2018, 67 DOI: 10.2337/db18-245-lb.Peer-Reviewed Original ResearchOnset of pubertyIGF-1RFVB/NJ miceIGF-1R levelsPhysiological insulin resistanceWeek old micePeri-pubertal girlsPituitary hormone productionT-testInitiation of pubertyStudent's t-testSteroid hormone synthesisActive folliculogenesisHPO axisOvarian axisInsulin resistanceRisk factorsReceptor expressionIGF-1Normal insulinOld miceVaginal openingPuberty developmentHormone productionSplice variant isoforms
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply