2025
Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors
Bagdas D, Sedaille J, Khan M, Okpala N, Addy N. Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors. Nicotine & Tobacco Research 2025, ntaf037. PMID: 40097606, DOI: 10.1093/ntr/ntaf037.Peer-Reviewed Original ResearchOral nicotine productsNicotine preferenceFemale adult Sprague-Dawley ratsBitter solutionsAdult Sprague-Dawley ratsNicotine delivery methodsChoice behaviorSprague-Dawley ratsDose-response analysisEvidence-based guidelinesTested nicotineNicotine solutionInfluence addictionSweet solutionsPresence of sweetenersBehavioral studiesNicotineSaccharinNicotine productsHarm reduction strategiesCombination of cinnamaldehydeRatsDifferential preferenceDelivery methodsMale
2021
Dietary Fats, Serum Cholesterol and Liver Cancer Risk: A Systematic Review and Meta-Analysis of Prospective Studies
Zhao L, Deng C, Lin Z, Giovannucci E, Zhang X. Dietary Fats, Serum Cholesterol and Liver Cancer Risk: A Systematic Review and Meta-Analysis of Prospective Studies. Cancers 2021, 13: 1580. PMID: 33808094, PMCID: PMC8037522, DOI: 10.3390/cancers13071580.Peer-Reviewed Original ResearchLiver cancer riskMeta-analysis of prospective studiesRisk of liver cancerCancer riskIntake of dietary saturated fatty acidsDietary saturated fatty acidsDose-response analysisProspective studyAssociated with higher risk of liver cancerHigher intakeHigher risk of liver cancerBetween-study variabilitySystematic reviewDietary fatLiver cancerSerum levelsHigh liver cancer riskHigher serum total cholesterolMeta-analysisSerum high-density lipoprotein (HDL) cholesterolHigh-density lipoprotein (HDL) cholesterolAssociated with liver cancerAssociated with higher riskSerum cholesterolHigher serum levelsTea Drinking and Risk of Cancer Incidence: A Meta-Analysis of Prospective Cohort Studies and Evidence Evaluation
Zhao L, Li Z, Feng G, Ji X, Tan Y, Li H, Gunter M, Xiang Y. Tea Drinking and Risk of Cancer Incidence: A Meta-Analysis of Prospective Cohort Studies and Evidence Evaluation. Advances In Nutrition 2021, 12: 402-412. PMID: 33002099, PMCID: PMC8009746, DOI: 10.1093/advances/nmaa117.Peer-Reviewed Original ResearchConceptsCancer riskDose-response analysisTea drinkingMeta-analysis of prospective cohort studiesEvidence of small-study effectsAssociation of tea drinkingMeta-analysisMeta-analysis of prospective studiesRisk of cancer incidenceAssociated with cancer riskCochrane Database of Systematic ReviewsExcess significance biasDatabase of Systematic ReviewsRestricted cubic spline regressionReview of prospective studiesSmall-study effectsCubic spline regressionIntake of black teaProspective studyProspective cohort studyIntake of green teaCancer sitesCancer incidenceWell-designed studiesComprehensive Meta-AnalysisAdmission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage
Acosta JN, Leasure AC, Kuohn LR, Both CP, Petersen NH, Sansing LH, Matouk CC, Testai F, Langefeld CD, Woo D, Kamel H, Murthy SB, Qureshi A, Mayer SA, Sheth KN, Falcone GJ. Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage. Critical Care Medicine 2021, 49: 828-837. PMID: 33591003, PMCID: PMC8611893, DOI: 10.1097/ccm.0000000000004891.Peer-Reviewed Original ResearchConceptsAdmission hemoglobin levelsHemoglobin levelsNontraumatic intracerebral hemorrhageIntracerebral hemorrhageHematoma volumePoor outcomeHematoma expansionIntracerebral hemorrhage patientsPredictors of outcomeSpontaneous intracerebral hemorrhageIndividual patient dataHigher hemoglobin levelsAdmission hematoma volumeExposure of interestDose-response analysisAdmission hemoglobinRankin ScalePrimary outcomeHemorrhage patientsFunctional outcomeRepeat CTClinical trialsObservational studyHemorrhage sizeBetter outcomes
2020
Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies
Zhao L, Li Z, Feng G, Ji X, Tan Y, Li H, Gunter M, Xiang Y. Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies. BMC Cancer 2020, 20: 101. PMID: 32024485, PMCID: PMC7003434, DOI: 10.1186/s12885-020-6561-9.Peer-Reviewed Original ResearchConceptsMeta-analyses of observational studiesExcess significance biasUmbrella reviewCoffee intakeMeta-analysesRandom-effects modelCancer riskEvidence of excess significance biasEvidence of small-study effectsMeta-analyses of associationsRisk of liver cancerObservational studySmall-study effectsFixed- and random-effects modelsRisk of liverIndividual meta-analysesMethodsWe searched PubMedWeb of ScienceCancer sitesCancer incidenceDose-response analysisEndometrial cancerInverse associationAssess heterogeneityPublication bias
2018
Dietary protein intake and risk of type 2 diabetes: a dose–response meta-analysis of prospective studies
Zhao L, Zhang Q, Liu X, Wu H, Zheng J, Xiang Y. Dietary protein intake and risk of type 2 diabetes: a dose–response meta-analysis of prospective studies. European Journal Of Nutrition 2018, 58: 1351-1367. PMID: 29858629, DOI: 10.1007/s00394-018-1737-7.Peer-Reviewed Original ResearchConceptsRisk of type 2 diabetesType 2 diabetesDietary protein intakeType 2 diabetes riskProtein intakeDose-response meta-analysis of prospective studiesDietary totalDose-response meta-analysisMeta-analysis of prospective studiesIncreased risk of type 2 diabetesPlant protein intakeRestricted cubic spline regression modelsAdjustment of potential confoundersAssociated with type 2 diabetes riskType 2 diabetes casesAnimal protein intakeMethodsA comprehensive literature reviewCubic spline regression modelDose-response analysisProspective studyProspective cohortIncreased riskWeb of ScienceEnergy intakePurposeThe associationAssociation between breastfeeding and risk of endometrial cancer
Ma X, Zhao L, Sun J, Yang Y, Zheng J, Gao J, Xiang Y. Association between breastfeeding and risk of endometrial cancer. European Journal Of Cancer Prevention 2018, 27: 144-151. PMID: 26258808, DOI: 10.1097/cej.0000000000000186.Peer-Reviewed Original Research
2015
Fish consumption and all-cause mortality: a meta-analysis of cohort studies
Zhao L, Sun J, Yang Y, Ma X, Wang Y, Xiang Y. Fish consumption and all-cause mortality: a meta-analysis of cohort studies. European Journal Of Clinical Nutrition 2015, 70: 155-161. PMID: 25969396, DOI: 10.1038/ejcn.2015.72.Peer-Reviewed Original ResearchConceptsRisk of all-cause mortalityAll-Cause MortalityReduced risk of all-cause mortalityCohort studyRelative riskMeta-analysis of cohort studiesCategories of fish intakeRisk of total deathFish intakeMeta-analysisLow categoryProspective cohort studyPotential nonlinear relationsDose-response analysisRandom-effects modelFish consumptionNever consumersWeb of ScienceChronic diseasesSystematic searchTotal deathReduced riskMortalityEffects modelCubic splines
1994
Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo
Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 1241-1248. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.Peer-Reviewed Original ResearchConceptsTGF beta 1TGF betaBeta 1Ability of trophoblastsAnti-TGF betaSevere alloimmune thrombocytopeniaThird trimester placentasPlatelet-poor serumDose-response analysisPregnancy tissueCord serumAlloimmune thrombocytopeniaCytokine presentUterine deciduaExtracellular matrixVillous syncytiotrophoblastTrimester placentaNormal serumHuman cytotrophoblastsGrowth factor-beta stimulatesOncofetal fibronectinNormal morphological differentiationCulture secreteStimulatory responseThrombocytopenic serum
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