2006
Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord
Kim Y, Martinez T, Deshpande D, Drummond J, Provost‐Javier K, Williams A, McGurk J, Maragakis N, Song H, Ming G, Kerr D. Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord. Annals Of Neurology 2006, 60: 716-728. PMID: 17192933, DOI: 10.1002/ana.21034.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsAntibodiesCell Line, TransformedCell SurvivalCoculture TechniquesCulture Media, ConditionedDisease Models, AnimalFemaleFree Radical ScavengersHumansInterleukinsMaleMiceMice, TransgenicMotor NeuronsNerve RegenerationNitric OxideOrgan Culture TechniquesSpinal CordSuperoxide DismutaseTreatment OutcomeVascular Endothelial Growth Factor AConceptsStem cell-derived motor neuronsVascular endothelial growth factorEmbryonic stem cell-derived motor neuronsEndothelial growth factorMotor neuronsNeutralizing antibodies to IL-1betaIL-6Levels of vascular endothelial growth factorOrganotypic slicesOrganotypic culturesAntibodies to IL-1betaGrowth factorAxon lengthToxic to motor neuronsAmyotrophic lateral sclerosisTreatment of amyotrophic lateral sclerosisCocultured motor neuronsPresence of reactive oxygen species scavengersCell survivalInterleukin (IL)-1betaSpinal cord organotypic culturesWild-typeOrganotypic slice culturesSecrete high levelsMotor neuron injury
2004
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes & Development 2004, 19: 138-151. PMID: 15598981, PMCID: PMC540232, DOI: 10.1101/gad.1246005.Peer-Reviewed Original ResearchConceptsNuclear Notch1Sensory neuronsAxon arborizationAccumulation of Notch1Conditional mouse mutantsAxon branch pointsAfferent fibersSensory gangliaAxonal arborizationAxonal lengthSevere reductionAxon lengthArborizationCre recombinaseNotch1Endocytic-lysosomal pathwayTargeted deletionSignificant increaseUnknown mechanismNeuronsOverexpression of NumbMouse mutantsGangliaNeurogenesisPathway
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