2021
Assessment of auditory and vestibular damage in a mouse model after single and triple blast exposures
Mao B, Wang Y, Balasubramanian T, Urioste R, Wafa T, Fitzgerald TS, Haraczy SJ, Edwards-Hollingsworth K, Sayyid ZN, Wilder D, Sajja VSSS, Wei Y, Arun P, Gist I, Cheng AG, Long JB, Kelley MW. Assessment of auditory and vestibular damage in a mouse model after single and triple blast exposures. Hearing Research 2021, 407: 108292. PMID: 34214947, PMCID: PMC8276524, DOI: 10.1016/j.heares.2021.108292.Peer-Reviewed Original ResearchConceptsDistortion product otoacoustic emissionsAuditory brainstem responseBlast exposureInner hair cellsBlast-exposed miceOuter hair cellsHair cellsHearing lossMouse modelVestibular systemLong-term hearing lossBalance deficitsInner earBlast-induced hearing lossPeripheral vestibular systemSpiral ganglion neuronsTraumatic brain injuryProduct otoacoustic emissionsMiddle ear dysfunctionBasal cochlear turnTympanic membrane ruptureCourse of recoveryUtricular hair cellsMultiple blast exposuresVestibular damage
2019
Auditory metabolomics, an approach to identify acute molecular effects of noise trauma
Ji L, Lee HJ, Wan G, Wang GP, Zhang L, Sajjakulnukit P, Schacht J, Lyssiotis CA, Corfas G. Auditory metabolomics, an approach to identify acute molecular effects of noise trauma. Scientific Reports 2019, 9: 9273. PMID: 31239523, PMCID: PMC6592947, DOI: 10.1038/s41598-019-45385-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory ThresholdEar, InnerHair Cells, AuditoryHearing Loss, Noise-InducedMetabolomeMiceMice, Inbred CBANoiseTandem Mass SpectrometryConceptsNoise exposureInner earHearing lossNoise-induced hearing lossHidden hearing lossAnimal-based studiesTemporary threshold shiftLow exposure levelsMouse inner earDuration of exposureAuditory traumaLiquid chromatography-coupled tandem mass spectrometryCochlear damageNoise traumaNovel therapiesCochlear functionMetabolic effectsMajor metabolic pathwaysThreshold shiftOxidative stressExposure levelsLC-MS/Molecular effectsEarExposureFunctional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss
Liu H, Lu J, Wang Z, Song L, Wang X, Li G, Wu H. Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss. Neuroscience Letters 2019, 707: 134268. PMID: 31103727, DOI: 10.1016/j.neulet.2019.05.022.Peer-Reviewed Original ResearchConceptsInner hair cellsModerate noise exposureHearing lossRibbon synapsesNoise exposureHair cellsPersistent reductionWhole-cell patch-clamp recordingsNoise-induced hearing lossSynapse functionAuditory afferent fibersHidden hearing lossABR wave ISynaptic vesiclesAuditory brainstem response (ABR) amplitudesPatch-clamp recordingsSevere noise exposureWhole mount immunofluorescence stainingPatch-clamp electrophysiologySensory hair cellsAfferent fibersABR thresholdPersistent alterationsExposure altersFunctional alterations
2017
A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall
Mei L, Chen J, Zong L, Zhu Y, Liang C, Jones R, Zhao H. A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall. Neurobiology Of Disease 2017, 108: 195-203. PMID: 28823936, PMCID: PMC5675824, DOI: 10.1016/j.nbd.2017.08.002.Peer-Reviewed Original ResearchConceptsCochlear lateral wallEndocochlear potentialHearing lossGap junctional functionDeafness mechanismLateral wallHeterozygous miceCx30 mutationsHair cell degenerationHomozygous knockout miceJunctional functionHeterozygous mouse modelGap junctionsOrgan of CortiSame gap junctional plaquesEP reductionFrequent causePathological changesMouse modelKnockout miceReceptor currentsCell degenerationNormal hearingHeterozygous mutationsMice
2013
Active cochlear amplification is dependent on supporting cell gap junctions
Zhu Y, Liang C, Chen J, Zong L, Chen G, Zhao H. Active cochlear amplification is dependent on supporting cell gap junctions. Nature Communications 2013, 4: 1786. PMID: 23653198, PMCID: PMC3675877, DOI: 10.1038/ncomms2806.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory ThresholdCochlear Microphonic PotentialsConnexin 26ConnexinsEvoked Potentials, Auditory, Brain StemGap JunctionsGene DeletionGene TargetingHair Cells, Auditory, OuterHearing LossLabyrinth Supporting CellsMiceMice, KnockoutMolecular Motor ProteinsNonlinear DynamicsOtoacoustic Emissions, SpontaneousSpiral GanglionConceptsActive cochlear amplificationOuter hair cellsCell gap junctionsHearing lossCochlear amplificationHair cellsGap junctionsDistortion product otoacoustic emissionsOuter hair cell electromotilityHair cell electromotilitySevere hearing lossProduct otoacoustic emissionsShorter outer hair cellsHair-bundle movementsOuter pillar cellsLeftward shiftOtoacoustic emissionsAcoustic stimulationDeiters' cellsHearing sensitivityConnexin 26Active cochlear mechanicsNovel findingsPillar cellsBundle movement
2010
Effect of daily noise exposure monitoring on annual rates of hearing loss in industrial workers
Rabinowitz PM, Galusha D, Kirsche SR, Cullen MR, Slade MD, Dixon-Ernst C. Effect of daily noise exposure monitoring on annual rates of hearing loss in industrial workers. Occupational And Environmental Medicine 2010, 68: 414. PMID: 21193566, PMCID: PMC3738059, DOI: 10.1136/oem.2010.055905.Peer-Reviewed Original ResearchConceptsNoise-induced hearing lossOccupational noise-induced hearing lossNoise exposureDaily noise exposureIntervention subjectsHearing lossPrevention of NIHLOccupational noise exposureHearing threshold levelsAppropriate control groupsHearing conservation programAnnual rateHigh-frequency hearingControl groupIntervention studiesPreventive interventionsFrequency hearingIndustrial workersFurther worseningIntervention effectsInterventionExposureDaily monitoringRegular feedbackAdministrative feedbackFrequency tuning of bone‐conducted tone burst‐evoked myogenic potentials recorded from extraocular muscles (BOVEMP) in normal human subjects
Donnellan K, Wei W, Jeffcoat B, Mustain W, Xu Y, Eby T, Zhou W. Frequency tuning of bone‐conducted tone burst‐evoked myogenic potentials recorded from extraocular muscles (BOVEMP) in normal human subjects. The Laryngoscope 2010, 120: 2555-2560. PMID: 21108434, DOI: 10.1002/lary.21100.Peer-Reviewed Original ResearchCumulative lead exposure and age-related hearing loss: The VA Normative Aging Study
Park S, Elmarsafawy S, Mukherjee B, Spiro A, Vokonas P, Nie H, Weisskopf M, Schwartz J, Hu H. Cumulative lead exposure and age-related hearing loss: The VA Normative Aging Study. Hearing Research 2010, 269: 48-55. PMID: 20638461, PMCID: PMC2934752, DOI: 10.1016/j.heares.2010.07.004.Peer-Reviewed Original ResearchConceptsAge-related hearing lossPure-tone averagePatella lead levelsCumulative lead exposureHearing lossHearing thresholdsNormative Aging StudyAssociated with poorer hearing thresholdsOdds of hearing lossAir conduction hearing thresholdsAssociated with hearing lossConduction hearing thresholdsPoorer hearing thresholdsAging StudyDevelopment of age-related hearing lossReduction of lead exposureVA Normative Aging StudyCross-sectional analysisLead exposureOccupational noiseHearing abilityK X-ray fluorescencePotential confoundersEpidemiological researchLead levelsSpecific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat
Strumbos J, Polley D, Kaczmarek L. Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat. Neuroscience 2010, 167: 567-572. PMID: 20219640, PMCID: PMC2854512, DOI: 10.1016/j.neuroscience.2010.02.046.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdaptation, PhysiologicalAnimalsAntibody SpecificityAuditory PathwaysAuditory ThresholdImmunohistochemistryIon Channel GatingNerve Tissue ProteinsNeuronal PlasticityRatsRats, Sprague-DawleyReaction TimeRhombencephalonShaw Potassium ChannelsSound LocalizationSynaptic TransmissionTime FactorsUp-RegulationConceptsTotal cellular levelsCytoplasmic C-terminusCellular levelVoltage-gated potassium channel subunitsPotassium channel subunitsTonotopic distributionAdult ratsC-terminusChannel proteinsChannel subunitsSound localization circuitIon channelsProteinExperience-dependent plasticityCultured neuronsPotassium channelsHigh-frequency stimuliAcute slicesMedial nucleusSynaptic activityAuditory neuronsKv3.1 proteinMin of exposureAction potentialsAcoustic stimulation
2006
Effects of intense noise exposure on the outer hair cell plasma membrane fluidity
Chen G, Zhao H. Effects of intense noise exposure on the outer hair cell plasma membrane fluidity. Hearing Research 2006, 226: 14-21. PMID: 16870367, DOI: 10.1016/j.heares.2006.06.007.Peer-Reviewed Original Research
2003
Mice lacking the B1 subunit of H+-ATPase have normal hearing
Dou H, Finberg K, Cardell EL, Lifton R, Choo D. Mice lacking the B1 subunit of H+-ATPase have normal hearing. Hearing Research 2003, 180: 76-84. PMID: 12782355, DOI: 10.1016/s0378-5955(03)00108-4.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAnimalsAnimals, NewbornAuditory ThresholdCochleaEar, InnerEmbryo, MammalianEmbryonic and Fetal DevelopmentEvoked Potentials, Auditory, Brain StemFemaleHearingIn Situ HybridizationMaleMiceMice, KnockoutProtein SubunitsTissue DistributionVacuolar Proton-Translocating ATPasesConceptsNormal inner ear functionInner ear functionMouse inner earInner earEar functionNormal hearingAuditory brainstem response testAutosomal recessive distal renal tubular acidosisSubunit null mutant miceDistal renal tubular acidosisInner ear developmentNormal inner ear developmentRecessive distal renal tubular acidosisRenal tubular acidosisSensorineural hearing lossB1 subunitNull mutant miceAcid-base homeostasisPhysiologic assessmentTubular acidosisClinical dataHearing lossPhysiologic effectsDuct epitheliumATPase B1 subunit
1998
The Effect of Masker Interaural Time Delay on the Masking Level Difference in Children with History of Normal Hearing or History of Otitis Media with Effusion
Hall J, Grose J, Dev M, Ghiassi S. The Effect of Masker Interaural Time Delay on the Masking Level Difference in Children with History of Normal Hearing or History of Otitis Media with Effusion. Ear & Hearing 1998, 19: 429-433. PMID: 9867291, DOI: 10.1097/00003446-199812000-00004.Peer-Reviewed Original ResearchA Multimodal Assessment of Sensory Thresholds in Aging
Stevens J, Cruz L, Marks L, Lakatos S. A Multimodal Assessment of Sensory Thresholds in Aging. The Journals Of Gerontology Series B 1998, 53B: p263-p272. PMID: 9679518, DOI: 10.1093/geronb/53b.4.p263.Peer-Reviewed Original ResearchConceptsWechsler Logical Memory TestLogical memory testAge-related capacityPicture Naming TestIndividual modalitiesMemory testForced-choice detectionNaming TestSensory tasksDetection taskSame taskMultimodal assessmentAge effectsTaskYoung subjectsHearingThreshold scoreScoresHigh-frequency hearingAverage scoreElderly subjectsLarge effectSame subjectsVibrotactionLow-frequency hearing
1995
Binaural summation after learning psychophysical functions for loudness
Marks L, Galanter E, Baird J. Binaural summation after learning psychophysical functions for loudness. Attention, Perception, & Psychophysics 1995, 57: 1209-1216. PMID: 8539096, DOI: 10.3758/bf03208377.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionAuditory ThresholdDichotic Listening TestsFemaleHumansIndividualityLoudness PerceptionMalePsychoacousticsReference ValuesConceptsPerceptual processesResponse-related processesStimulus rangeBinaural summationPerceptual eventsPsychophysical functionsLoudness scaleMonaural signalAlgomBinaural signalsTrainingDozen subjectsLoudness exponentLoudnessLoudness summationLoudness matchesNominal functionPresent studySubjectsNumeric responsesBasic rules
1989
Discrimination of frequency transitions by human infants.
Aslin R. Discrimination of frequency transitions by human infants. The Journal Of The Acoustical Society Of America 1989, 86: 582-90. PMID: 2768673, DOI: 10.1121/1.398237.Peer-Reviewed Original Research
1981
Discrimination of voice onset time by human infants: new findings and implications for the effects of early experience.
Aslin R, Pisoni D, Hennessy B, Perey A. Discrimination of voice onset time by human infants: new findings and implications for the effects of early experience. Child Development 1981, 52: 1135-45. PMID: 7318516, PMCID: PMC3499965, DOI: 10.2307/1129499.Peer-Reviewed Original Research
1969
EFFECTS OF HALOTHANE UPON AUDITORY RECOVERY FUNCTIONS IN CATS
KITAHATA L, AMAKATA Y, GALAMBOS R. EFFECTS OF HALOTHANE UPON AUDITORY RECOVERY FUNCTIONS IN CATS. Journal Of Pharmacology And Experimental Therapeutics 1969, 167: 14-25. PMID: 5772744, DOI: 10.1016/s0022-3565(25)28249-0.Peer-Reviewed Original ResearchConceptsMedial geniculateEvoked responsesAuditory cortexDose-related depressant effectInferior colliculusCentral auditory nucleiLevel of drug actionAscending auditory pathwayEffects of halothaneNeuronal excitabilityAuditory pathwayFunctional depressionAuditory nucleiNuclear massesDrug actionPermanently implanted electrodesDepressant effectGeniculateRecovery curvesCortexNO effectRecovery functionHalothaneDecreased amplitudeColliculus
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply