2021
Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia
Gao X, Gao M, Gorecka J, Langford J, Liu J, Luo J, Taniguchi R, Matsubara Y, Liu H, Guo L, Gu Y, Qyang Y, Dardik A. Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia. Cells 2021, 10: 792. PMID: 33918299, PMCID: PMC8066461, DOI: 10.3390/cells10040792.Peer-Reviewed Original ResearchConceptsLimb-threatening ischemiaSmooth muscle cellsHindlimb ischemiaFunctional outcomeChronic limb-threatening ischemiaMuscle cellsVascular endothelial growth factor (VEGF) expressionM2-type macrophagesMurine hindlimb ischemia modelNumber of macrophagesGrowth factor expressionLaser Doppler imagingStem cell sourceHindlimb ischemia modelStem cellsConsiderable ethical issuesTranslatable therapyIschemic limbsRenewable stem cell sourcesIschemia modelCapillary densityBlood flowIschemiaNovel treatmentsNude mice
2019
Cardiomyocyte d-dopachrome tautomerase protects against heart failure
Ma Y, Su KN, Pfau D, Rao VS, Wu X, Hu X, Leng L, Du X, Piecychna M, Bedi K, Campbell SG, Eichmann A, Testani JM, Margulies KB, Bucala R, Young LH. Cardiomyocyte d-dopachrome tautomerase protects against heart failure. JCI Insight 2019, 4: e128900. PMID: 31484822, PMCID: PMC6777911, DOI: 10.1172/jci.insight.128900.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCardiomegalyCytokinesDisease Models, AnimalEchocardiographyGene DeletionGene ExpressionGenetic Predisposition to DiseaseHeart FailureHumansIntramolecular OxidoreductasesMaleMAP Kinase Kinase KinasesMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacRecombinant ProteinsSignal TransductionTranscriptomeVascular Endothelial Growth Factor AConceptsTransverse aortic constrictionHeart failureRecombinant DDTConnective tissue growth factor expressionTissue growth factor expressionMore interstitial fibrosisAdvanced heart failureCardiac pressure overloadExperimental heart failureCardiac contractile dysfunctionLittermate control miceSmad-2 activationGrowth factor expressionSarcoplasmic reticulum calcium ATPaseMacrophage migration inhibitory factor (MIF) familyReticulum calcium ATPasePulmonary edemaCardiac dilatationContractile dysfunctionControl miceInterstitial fibrosisPressure overloadAntifibrotic actionAortic constrictionLow VEGF
2017
Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone
Espinosa-Garcia C, Sayeed I, Yousuf S, Atif F, Sergeeva E, Neigh G, Stein D. Abstract TP83: Stress Exacerbates Global Ischemia-induced Inflammatory Response: Intervention by Progesterone. Stroke 2017, 48 DOI: 10.1161/str.48.suppl_1.tp83.Peer-Reviewed Original ResearchPro-inflammatory cytokinesNeuronal lossExposed to social defeat stressGlobal ischemiaIncreased brain-derived neurotrophic factor expressionInflammatory responsePost-ischemiaFactor expressionPost-ischemic inflammatory responseBrain-derived neurotrophic factor expressionAssociated with increased riskSocial defeat stressIschemia-induced inflammatory responseAdult male ratsAssociated with increased risk of strokeFour-vessel occlusion modelNeurotrophic factor expressionGrowth factor expressionHippocampal CA1 regionGlobal ischemic injuryActivation of microgliaExacerbated microglial activationRisk of strokeDays post-ischemiaDefeat stress
2014
mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium
Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsTNF-α expressionTIA-1 expressionEndometrial stromal cellsIL-6Pathogenesis of endometriosisMenstrual cycleTIA-1Endometrial tissueEctopic endometriumImmune factorsHistological scoresCultured human endometrial stromal cellsSteroid hormonesStromal cellsGrowth factorElevated IL-6Ectopic endometrial tissueNormal menstrual cycleEutopic endometrial tissuesGrowth factor expressionT-cell intracellular antigenEndometrial cytokinesEndometrial functionControl women
2013
Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats
Bagdas D, Etoz B, Ozturkoglu S, Cinkilic N, Ozyigit M, Gul Z, Buyukcoskun N, Ozluk K, Gurun M. Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats. Biological And Pharmaceutical Bulletin 2013, 37: 361-370. PMID: 24389556, DOI: 10.1248/bpb.b13-00635.Peer-Reviewed Original ResearchConceptsSkin flap survivalFlap survivalDiabetic ratsNondiabetic ratsCapillary densityBlood perfusionVascular endothelial growth factor (VEGF) expressionPostoperative day 7Nitric oxide levelsMale Wistar ratsDorsal skin flapDorsal skin flap modelSkin flap modelGrowth factor expressionPotent antioxidant effectsChlorogenic acidRegional blood perfusionCGA treatmentWistar ratsSOD levelsOxide levelsSkin flapsNO levelsFlap tissueDay 7
2008
Bevacizumab suppresses neuroblastoma progression in the setting of minimal disease
Sims T, Williams R, Ng C, Rosati S, Spence Y, Davidoff A. Bevacizumab suppresses neuroblastoma progression in the setting of minimal disease. Surgery 2008, 144: 269-275. PMID: 18656635, PMCID: PMC2525799, DOI: 10.1016/j.surg.2008.04.009.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsAutocrine CommunicationBevacizumabCell Line, TumorCell ProliferationDisease ProgressionFibroblast Growth Factor 2HumansMiceMice, SCIDNeuroblastomaReceptors, Vascular Endothelial Growth FactorSignal TransductionTumor Cells, CulturedVascular Endothelial Growth Factor AConceptsVascular endothelial growth factorLuciferase-expressing tumor cellsAnti-VEGF monoclonal antibodyUpregulation of proangiogenic factorsMaximal antitumor efficacyVEGF signaling inhibitionActivity of bevacizumabDecreased tumor burdenFibroblast growth factor expressionEndothelial growth factorGrowth factor expressionIn vitro studiesCytoreductive therapyIntraperitoneal bevacizumabBevacizumab treatmentTumor burdenDisseminated diseaseDisseminated neuroblastomaMaintenance therapyMinimal diseaseCombination therapyNeuroblastoma cell linesIn vivo studiesProlonged survivalAntitumor efficacy
2007
Growth Factor Expression With Different Wound Treatments After Laser Resurfacing
Lee C, Whang J, Lazova R, Ciesielski TE, Thomson JG, McCarthy T, Persing JA. Growth Factor Expression With Different Wound Treatments After Laser Resurfacing. Aesthetic Surgery Journal 2007, 27: 55-64. PMID: 19341630, DOI: 10.1016/j.asj.2006.12.002.Peer-Reviewed Original ResearchGrowth factorHealing processWound healingReverse transcriptase-polymerase chain reactionChain reactionTranscriptase-polymerase chain reactionTranscription-polymerase chain reactionWound treatmentGrowth factor expressionMessenger RNA levelsDifferent wound treatmentsControl subjectsBiopsy specimensOcclusive dressingHistologic evaluationPetrolatum ointmentHistologic studyHuman epidermal keratinocytesTreatment woundsBack of ratsLess improvementFactor expressionRNA levelsTissue expressionEpidermal keratinocytes
2006
Vascular endothelial growth factor, FLT‐1, and FLK‐1 analysis in a pancreatic cancer tissue microarray
Chung GG, Yoon HH, Zerkowski MP, Ghosh S, Thomas L, Harigopal M, Charette LA, Salem RR, Camp RL, Rimm DL, Burtness BA. Vascular endothelial growth factor, FLT‐1, and FLK‐1 analysis in a pancreatic cancer tissue microarray. Cancer 2006, 106: 1677-1684. PMID: 16532435, DOI: 10.1002/cncr.21783.Peer-Reviewed Original ResearchConceptsPancreatic cancer tissue microarrayCancer tissue microarrayTissue microarrayVEGF receptor 1Flt-1Receptor 1Kaplan-Meier survival curvesVascular endothelial growth factor (VEGF) expressionIndependent prognostic factorVascular endothelial growth factorFlk-1Growth factor expressionEndothelial growth factorPrimary antibodyFlt-1 expressionOverall survivalPrognostic factorsWorse survivalAggressive diseaseDisease stagePoor prognosisTumor expressionPancreatic cancerPancreatic adenocarcinomaPrincipal receptor
2004
Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Does Not Improve Paclitaxel Effect in an Orthotopic Mouse Model of Lung Cancer
Onn A, Isobe T, Wu W, Itasaka S, Shintani T, Shibuya K, Kenji Y, O’Reilly M, Fidler IJ, Herbst RS. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Does Not Improve Paclitaxel Effect in an Orthotopic Mouse Model of Lung Cancer. Clinical Cancer Research 2004, 10: 8613-8619. PMID: 15623645, DOI: 10.1158/1078-0432.ccr-04-1241.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, Bronchiolo-AlveolarAnimalsAntineoplastic Agents, PhytogenicCarcinoma, Non-Small-Cell LungDrug Therapy, CombinationEnzyme ActivationEnzyme InhibitorsErbB ReceptorsFibroblast Growth Factor 2HumansLung NeoplasmsMaleMiceMice, NudeMitogen-Activated Protein KinasesModels, AnimalPaclitaxelPhosphorylationPyrimidinesPyrrolesSurvival RateConceptsEGFR tyrosine kinase inhibitorsTumor implantationLung cancerKinase inhibitorsEpidermal growth factor receptor tyrosine kinase inhibitorsGrowth factor receptor tyrosine kinase inhibitorsReceptor tyrosine kinase inhibitorsBasic fibroblast growth factor expressionCombination of paclitaxelFibroblast growth factor expressionGroups of miceLungs of miceOrthotopic mouse modelHuman lung cancerTyrosine kinase inhibitorsGrowth factor expressionMaximal therapeutic effectHuman lung adenocarcinoma cellsLung adenocarcinoma cellsPaclitaxel 100Phosphorylation of EGFRConcurrent administrationEGFR-TKITherapeutic effectEpidermal growth factor receptor (EGFR) activation
2003
Vascular Endothelial Growth Factor Expression, β-Catenin Tyrosine Phosphorylation, and Endothelial Proliferative Behavior: A Pathway for Transformation?
Ilan N, Tucker A, Madri JA. Vascular Endothelial Growth Factor Expression, β-Catenin Tyrosine Phosphorylation, and Endothelial Proliferative Behavior: A Pathway for Transformation? Laboratory Investigation 2003, 83: 1105-1115. PMID: 12920240, DOI: 10.1097/01.lab.0000083531.84403.8b.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BlockingAntigens, CD1beta CateninCell DivisionCell Transformation, NeoplasticCytoskeletal ProteinsEndothelial Growth FactorsEndothelium, VascularExtracellular Matrix ProteinsHemangioendotheliomaHumansIntercellular Signaling Peptides and ProteinsLymphokinesPhosphorylationTrans-ActivatorsTumor Cells, CulturedTyrosineUmbilical VeinsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth FactorsConceptsVascular endothelial growth factorEOMA cellsCD1 levelsFlk-1Vascular endothelial growth factor (VEGF) expressionExogenous vascular endothelial growth factorEndogenous vascular endothelial growth factorEndothelial cell tumorsGrowth factor expressionEndothelial growth factorTyrosine phosphorylationNuclear beta-catenin localizationNuclear localizationProliferative behaviorΒ-catenin tyrosine phosphorylationHuman endothelial cellsComponent expression levelsCD1 expressionCell tumorsCommon tumorsImmune complex kinase assayEndothelial cell transformationMitogen-activated protein kinase activationPrimary human endothelial cellsAutocrine loopTumor Cavitation Is Associated With Epidermal Growth Factor Expression and Is a Predictor of Poor Outcome in Patients With Stage I Non-Small Cell Lung Cancer
Onn A, Marom E, Isobe T, Choe D, Correa A, Putnam J, Herbst R. Tumor Cavitation Is Associated With Epidermal Growth Factor Expression and Is a Predictor of Poor Outcome in Patients With Stage I Non-Small Cell Lung Cancer. CHEST Journal 2003, 124: 102s. DOI: 10.1378/chest.124.4_meetingabstracts.102s-a.Peer-Reviewed Original Research
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