2023
Multiple Subthreshold GPCR Signals Combined by the G-Proteins Gαq and Gαs Activate the Caenorhabditis elegans Egg-Laying Muscles
Olson A, Butt A, Christie N, Shelar A, Koelle M. Multiple Subthreshold GPCR Signals Combined by the G-Proteins Gαq and Gαs Activate the Caenorhabditis elegans Egg-Laying Muscles. Journal Of Neuroscience 2023, 43: 3789-3806. PMID: 37055179, PMCID: PMC10219013, DOI: 10.1523/jneurosci.2301-22.2023.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsMultiple G protein-coupled receptorsMuscle cellsMuscle activitySerotonin G protein-coupled receptorsDesigner G protein-coupled receptorsIntact animalsG proteinsEndogenous G protein-coupled receptorsIndividual G protein-coupled receptorsGPCR signalsCalcium activityEgg-laying musclesSerotoninIndividual neuronsDouble knockoutNeuronsBehavioral outcomesMuscleMost cellsG protein GαqCellsSubthreshold signalEgg-laying systemSER-1
2008
Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex*
Yuen EY, Jiang Q, Chen P, Feng J, Yan Z. Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex*. Journal Of Biological Chemistry 2008, 283: 17194-17204. PMID: 18442977, PMCID: PMC2427346, DOI: 10.1074/jbc.m801713200.Peer-Reviewed Original ResearchConceptsPFC pyramidal neuronsExtracellular signal-regulated kinasePyramidal neuronsPrefrontal cortexNMDAR currentsN-methyl-D-aspartate receptor currentsN-methyl-D-aspartate receptor channelsSynaptic NMDAR responsesNMDAR responsesNMDAR functionActivation of ERKDendritic processesReceptor currentsPFC neuronsSignal-regulated kinaseReceptor activationMental disordersImmunocytochemical studyIntact animalsCounteractive effectsReceptor channelsInhibitory effectNeuronsCellular knockdownDependent pathway
2007
Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats
Leranth C, Szigeti-Buck K, MacLusky NJ, Hajszan T. Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats. Endocrinology 2007, 149: 988-994. PMID: 18048497, PMCID: PMC2275360, DOI: 10.1210/en.2007-1053.Peer-Reviewed Original ResearchConceptsAdult male ratsMedial prefrontal cortexMale ratsSpine synapsesCA1 hippocampal areaAsymmetric spine synapsesSham-operated animalsElectron microscopic stereologyImpairs synaptogenesisSynaptogenic actionsOvariectomized ratsHippocampal areaTestosterone supplementationTestosterone propionateEstrogen receptorExposure measurement dataOil vehicleCompensatory increaseIntact animalsSynthetic xenoestrogenPrefrontal cortexRatsHippocampusCastrated malesPotential mechanisms
2006
Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice
Steiner RC, Hsiung HM, Picciotto MR. Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice. Behavioural Brain Research 2006, 171: 56-62. PMID: 16621045, DOI: 10.1016/j.bbr.2006.03.022.Peer-Reviewed Original ResearchConceptsKnockout miceLocomotor sensitizationCocaine-induced locomotor sensitizationAmphetamine-regulated transcriptEffects of psychostimulantsRange of dosesAcute cocaineBone resorptionAmphetamine injectionsNucleus accumbensIntravenous cocaineIntact animalsMiceCocaineSchedule of reinforcementInsulin regulationCART geneSensitizationWild-type siblingsPhysiological functionsRegulatory roleStriatumAccumbensPsychostimulantsRats
2001
Adhesion Molecules and Axon Pathfinding
B.Levitan I, Kaczmarek L. Adhesion Molecules and Axon Pathfinding. 2001, 435-466. DOI: 10.1093/oso/9780195145236.003.0017.Peer-Reviewed Original ResearchNervous systemNeuronal activityDendritic branchesSuperior cervical ganglionDendritic branching patternsMature nervous systemTypes of synapsesIntact nervous systemCervical ganglionLong-term regulationSynaptic connectionsIntact animalsNeuronal structuresAdhesion moleculesNeuronsElectrical activityGangliaFluorescent cellsBranching patternDendritesCellsSpecific patternsAxonsMiceActivity
2000
Biliary copper excretion capacity in intact animals: Correlation between ATP7B function, hepatic mass, and biliary copper excretion
Schilsky M, Irani A, Gorla G, Volenberg I, Gupta S. Biliary copper excretion capacity in intact animals: Correlation between ATP7B function, hepatic mass, and biliary copper excretion. Journal Of Biochemical And Molecular Toxicology 2000, 14: 210-214. PMID: 10789499, DOI: 10.1002/(sici)1099-0461(2000)14:4<210::aid-jbt5>3.0.co;2-g.Peer-Reviewed Original ResearchConceptsBiliary copper excretionCopper excretionLong-Evans AgoutiHepatic massIntact animalsLEA ratsLEC ratsExcretion capacityMinute study periodTwo-thirds partial hepatectomyLong-Evans Cinnamon ratsBile collectionPathophysiological mechanismsNovel therapiesHepatocyte massExcretionRatsPartial hepatectomyTransient increaseStudy periodATP7B functionOne-third
1998
The α-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys
Franowicz JS, Arnsten A. The α-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys. Psychopharmacology 1998, 136: 8-14. PMID: 9537677, DOI: 10.1007/s002130050533.Peer-Reviewed Original ResearchConceptsYoung adult rhesus monkeysAdult rhesus monkeysHigh dosesDorsolateral prefrontal cortical functionRhesus monkeysDose of idazoxanEffects of guanfacinePrefrontal cortical functionAntagonist idazoxanNoradrenergic agonistsCatecholamine depletionMild sedationAdrenergic agonistsCortical functionDrug effectsAged animalsGuanfacineAdrenergic receptorsLow dosesAged monkeysEffective doseIntact animalsIdazoxanDosesYoung animals
1997
The IRS‐signalling system during insulin and cytokine action
Yenush L, White M. The IRS‐signalling system during insulin and cytokine action. BioEssays 1997, 19: 491-500. PMID: 9204766, DOI: 10.1002/bies.950190608.Peer-Reviewed Original ResearchConceptsIRS-1Grb2-binding proteinGeneral cell growthStructure/function relationshipsAnalysis of miceDrosophila proteinIRS proteinsImportant physiological roleSubstrate recognitionDocking moleculeIntracellular substratesIRS-2Physiological roleCell growthFunction relationshipsProteinDependent diabetes mellitusGrowth factorCytokine actionInsulin actionDiabetes mellitusGlucose metabolismReceptor systemGrowth hormoneIntact animals
1995
Regulation of Transgenic Class II Major Histocompatibility Genes in Murine Langerhans Cells
Longley J, Ding T, Levin D, Lewis J, Edelson R, Tigelaar R, Flavell R. Regulation of Transgenic Class II Major Histocompatibility Genes in Murine Langerhans Cells. Journal Of Investigative Dermatology 1995, 104: 329-334. PMID: 7860996, DOI: 10.1111/1523-1747.ep12665365.Peer-Reviewed Original ResearchConceptsSplenic dendritic cellsEpidermal Langerhans cellsLangerhans cellsDendritic cellsE expressionClass II major histocompatibility complex moleculesLangerhans cells expressionMurine Langerhans cellsMajor histocompatibility complex moleculesNear-normal levelsB6 genetic backgroundHistocompatibility complex moleculesMajor histocompatibility complex class II gene expressionImmune functionClass II proteinsImmunoperoxidase stainingCell-specific regulatory sequencesClass II gene expressionTransgenic miceCell expressionImmunofluorescence cytometryIntact animalsDecrease expressionMajor histocompatibility genesHistocompatibility genes
1993
Chronic regulation of the Na/H antiporter.
Alpern RJ, Yamaji Y, Cano A, Horie S, Miller RT, Moe OW, Preisig PA. Chronic regulation of the Na/H antiporter. Translational Research 1993, 122: 137-40. PMID: 8393472.Peer-Reviewed Original ResearchConceptsNa/H antiporter activityNa/H antiporterChronic regulationH antiporterAcute inhibitory effectRabbit proximal tubule cellsAcid-induced increaseProximal tubule cellsOpossum kidney cellsMRNA abundanceProtein kinase AChronic decreaseAntiporter activityChronic studiesChronic activationTubule cellsImmediate early genesIntact animalsKinase AInhibitory effectProtein synthesisNonrenal cellsPrimary culturesC-fosExtracellular fluid
1986
Augmentation of neutral sodium chloride absorption by increased flow rate in rat ileum in vivo.
Harris M, Dobbins J, Binder H. Augmentation of neutral sodium chloride absorption by increased flow rate in rat ileum in vivo. Journal Of Clinical Investigation 1986, 78: 431-438. PMID: 3734099, PMCID: PMC423573, DOI: 10.1172/jci112594.Peer-Reviewed Original ResearchConceptsNeutral sodium chloride absorptionSodium chloride absorptionRat ileumChloride absorptionIntraluminal volumeAddition of furosemideTransmural potential differenceSingle-pass perfusionOutflow tubingIntraluminal pressureSodium absorptionPerfusion mediumIntact animalsElectrolyte absorptionIleumElectrolyte transportRinger's solutionIncreased ratesPerfusion rateRemoval of sodiumStepwise increaseMinimal changesSeparate experimentsUnstirred layer thicknessSolute absorption
1983
Temperature compensation of the threshold potential for excitation of the snail bursting neuron
Zečević D, Pašić M. Temperature compensation of the threshold potential for excitation of the snail bursting neuron. Comparative Biochemistry And Physiology Part A Molecular & Integrative Physiology 1983, 76: 173-176. DOI: 10.1016/0300-9629(83)90310-9.Peer-Reviewed Original Research
1973
CHAPTER 1 Growth Hormone and Prolactin from Rat Pituitary Tumor Cells11Preparation of this review and the results of original experiments described were supported in part by a research grant from the USPHS (AM 11011). P. S. Dannies is a Postdoctoral Research Fellow of The Arthritis Foundation.
Dannies P, Tashjian A. CHAPTER 1 Growth Hormone and Prolactin from Rat Pituitary Tumor Cells11Preparation of this review and the results of original experiments described were supported in part by a research grant from the USPHS (AM 11011). P. S. Dannies is a Postdoctoral Research Fellow of The Arthritis Foundation. 1973, 561-569. DOI: 10.1016/b978-0-12-427150-0.50128-5.Peer-Reviewed Original ResearchGrowth hormoneRat pituitary tumor cellsPituitary tumor cellsPituitary cellsTumor cellsNormal pituitary cellsMechanism of actionArthritis FoundationIntact animalsComplement fixationProlactinHormoneCell populationsHomogeneous cell populationClonal strainsUseful modelCellsVariety of factorsCell homogenatesMicrocomplement fixationFixationCulture medium
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