2025
Glomerular mesangial cells derived complement factor H regulates complement activation, influences cell proliferation, and maintains actin cytoskeleton
Li Y, Ni X, Li X, Kang Y, Yuan X, Xu G, Wang T, Li D, Shi S, Lv J, Zhao M, Zhang H, Zhu L. Glomerular mesangial cells derived complement factor H regulates complement activation, influences cell proliferation, and maintains actin cytoskeleton. International Immunopharmacology 2025, 154: 114544. PMID: 40157080, DOI: 10.1016/j.intimp.2025.114544.Peer-Reviewed Original ResearchConceptsActin cytoskeletonGlomerular mesangial cellsInfluence cell proliferationCell proliferationSingle-cell sequencing dataComplement factor HNon-canonical functionsExpression of Cdc42Mesangial cellsSequence dataCell motilityAffecting cell proliferationCytoskeletonRegulate complement activationRegulatory roleCanonical functionActinComplement activationIndependent of complement activationFactor HIgA1-containing immune complexesComplement proteinsCellsComplement-induced damageExpression
2021
The factors for the early and late development of midbrain dopaminergic neurons segregate into two distinct evolutionary clusters
Niu Y, Moghimyfiroozabad S, Moghimyfiroozabad A, Tierney T, Alavian K. The factors for the early and late development of midbrain dopaminergic neurons segregate into two distinct evolutionary clusters. Brain Disorders 2021, 1: 100002. DOI: 10.1016/j.dscb.2021.100002.Peer-Reviewed Original ResearchTranscription factorsNon-canonical functionsMidbrain dopaminergic neuronsDistinct evolutionary pathwaysEntire human proteomeNovel molecular connectionDopaminergic neuronsPotential novel linkPhylogenetic profilesEvolutionary pathwaysHuman proteomeEvolutionary scenarioMolecular connectionEvolutionary clustersDevelopmental pathwaysNovel linkNeuronal differentiationNovel linkageDevelopmental cascadeParkinson's diseasePathwayNeuronsMotor behaviorControl of emotionsProteome
2020
Co-option of Neutrophil Fates by Tissue Environments
Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fernández-Calvo G, Khoyratty TE, van Grinsven E, González-Hernández S, Nicolás-Ávila JÁ, Vicanolo T, Maccataio A, Benguría A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Martín-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, Sánchez-Cabo F, Nistal-Villán E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A. Co-option of Neutrophil Fates by Tissue Environments. Cell 2020, 183: 1282-1297.e18. PMID: 33098771, DOI: 10.1016/j.cell.2020.10.003.Peer-Reviewed Original ResearchConceptsNeutrophil fateDepletion of neutrophilsHematopoietic recoveryVascular repairNeutrophil statesNeutrophil propertiesViral infectionNeutrophilsTarget tissuesHealthy tissueGenotoxic injuryEarly ageMultiple tissuesTissueTissue environmentPhysiological demandsInflammationHematopoietic homeostasisCXCR4LungNon-canonical functionsInjuryCancerInfectionLeukocytes
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