2020
Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J
Cueto A, Álvarez L, García M, Artime E, Barrios A, Rodríguez-Uña I, Coca-Prados M, González-Iglesias H. Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J. Diagnostics 2020, 10: 425. PMID: 32585848, PMCID: PMC7345206, DOI: 10.3390/diagnostics10060425.Peer-Reviewed Original ResearchImmune responseSystemic levelsOptic nerve damageImportant molecular changesDiagnosis of glaucomaComplement factor HCandidate molecular biomarkersGlaucomatous miceAdvanced diseaseNerve damageControl miceGlaucoma developmentComplement system proteinsSystemic alterationsDBA/2J miceAnimal modelsComplement C4AFicolin-3Potential biomarkersDifferent experimental groupsEnzyme immunoassayApolipoprotein A4Neurodegenerative diseasesGlaucomaSerum samples
2019
Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight
Mancini G, Pirruccio K, Yang X, Blücher M, Rodeheffer M, Horvath TL. Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight. Cell Reports 2019, 26: 2849-2858.e4. PMID: 30865877, PMCID: PMC6876693, DOI: 10.1016/j.celrep.2019.02.039.Peer-Reviewed Original ResearchConceptsKnockout miceBody weightMitochondria-endoplasmic reticulum interactionSystemic metabolic dysregulationImpaired glucose metabolismHigh-fat dietObese human subjectsCalorie-dense foodsMitofusin 2Control miceStandard chowLean controlsMetabolic dysregulationFood intakeAdult miceGlucose metabolismStandard dietAdipose tissueBrown fatGlucose utilizationAdiposityTissue levelsSystemic levelsMiceAdult animals
2013
Community differentiation of the cutaneous microbiota in psoriasis
Alekseyenko A, Perez-Perez G, De Souza A, Strober B, Gao Z, Bihan M, Li K, Methé B, Blaser M. Community differentiation of the cutaneous microbiota in psoriasis. Microbiome 2013, 1: 31. PMID: 24451201, PMCID: PMC4177411, DOI: 10.1186/2049-2618-1-31.Peer-Reviewed Original ResearchCutaneous microbiotaLesion specimensCommon chronic inflammatory diseaseSkin typeChronic inflammatory diseasePsoriasis patientsPsoriatic patientsContralateral skinDifferential microbiotaInflammatory diseasesSkin colonizationHealthy controlsPsoriatic lesionsLesion siteDiagnostic significanceLesion samplesClinical diagnosisPsoriasis samplesPsoriasisSystemic levelsUseful predictorConclusionsOur resultsMicrobiotaPatientsLesions
2012
Impact of epidermal desquamation on tissue stores of iron
Milstone LM, Hu RH, Dziura JD, Zhou J. Impact of epidermal desquamation on tissue stores of iron. Journal Of Dermatological Science 2012, 67: 9-14. PMID: 22575277, PMCID: PMC3374011, DOI: 10.1016/j.jdermsci.2012.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesCell ProliferationDisease Models, AnimalEpidermisFemaleGene Expression RegulationHemochromatosisHemochromatosis ProteinHepcidinsHistocompatibility Antigens Class IHomeostasisHuman papillomavirus 16HumansIronKidneyLiverMaleMembrane ProteinsMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMice, TransgenicPapillomavirus InfectionsReceptors, TransferrinConceptsIron metabolismDifferent mouse modelsSignificant reductionHPV16 E7 geneSystemic iron metabolismSystemic proteinsIron statusMouse modelTissue storesE7 genesSystemic levelsEpidermal turnoverInternal organsEpidermal desquamationTransferrin receptorMetabolic studiesKnockout modelsCorneocyte desquamationDesquamationKidneyHuman skinEpidermal homeostasisMetabolismEpidermisSkin
1999
A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo
Grey A, Mitnick M, Masiukiewicz U, Sun B, Rudikoff S, Jilka R, Manolagas S, Insogna K. A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo. Endocrinology 1999, 140: 4683-4690. PMID: 10499526, DOI: 10.1210/endo.140.10.7036.Peer-Reviewed Original ResearchConceptsParathyroid hormoneInterleukin-6Bone resorptionBiochemical markersPTH infusionEffect of PTHIL-6 productionCytokine interleukin-6Bone-resorbing cellsRelease of calciumPrimary hyperparathyroidismSerum levelsOsteoblastic cellsParacrine agentsCalcium homeostasisExperimental animalsPermissive roleChronic deficiencyResorptionImportant mediatorSystemic levelsBone formationRegulatory effectsInfusionMarkers
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