2024
Complement factor H in molecular regulation of angiogenesis
Li J, Wang K, Starodubtseva M, Nadyrov E, Kapron C, Hoh J, Liu J. Complement factor H in molecular regulation of angiogenesis. Medical Review 2024, 4: 452-466. PMID: 39444793, PMCID: PMC11495524, DOI: 10.1515/mr-2023-0048.Peer-Reviewed Original ResearchComplement factor HComplement factor H geneAge-related macular degenerationComplement factor H proteinFactor HComplement activation fragmentsC-reactive proteinAnti-angiogenic effectsEndothelial heparan sulfateChoroidal neovascularizationMacular degenerationRegulation of angiogenesisMolecular regulation of angiogenesisDeficient miceComplement 3aMembrane attack complexComplement 5aPro-angiogenic eventsAngiogenesis-related diseasesCFH expressionPro-angiogenic capacityAlternative pathwayTherapeutic potentialComplement systemBlood vessels
2023
The local microenvironment drives activation of neutrophils in human brain tumors
Maas R, Soukup K, Fournier N, Massara M, Galland S, Kornete M, Wischnewski V, Lourenco J, Croci D, Álvarez-Prado Á, Marie D, Lilja J, Marcone R, Calvo G, Santalla Mendez R, Aubel P, Bejarano L, Wirapati P, Ballesteros I, Hidalgo A, Hottinger A, Brouland J, Daniel R, Hegi M, Joyce J. The local microenvironment drives activation of neutrophils in human brain tumors. Cell 2023, 186: 4546-4566.e27. PMID: 37769657, DOI: 10.1016/j.cell.2023.08.043.Peer-Reviewed Original ResearchTumor-associated neutrophilsHuman brain tumorsBrain tumorsTumor necrosis factor alphaDistinct inflammatory signatureOverall immune suppressionBrain metastasis patientsPro-inflammatory mediatorsSoluble inflammatory mediatorsAbundant immune cellsNecrosis factor alphaActivation of neutrophilsTumor-associated macrophagesPro-angiogenic capacityBrain metastasesInflammatory signatureMetastasis patientsInflammatory mediatorsNeutrophil phenotypeImmune suppressionPeripheral bloodBlood neutrophilsDifferent cancer typesImmune cellsBrain microenvironment
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