2024
Validation of dot blot immunoassay for measurement of complement opsonization of nanoparticles
Li Y, Monte A, Dylla L, Moghimi S, Simberg D. Validation of dot blot immunoassay for measurement of complement opsonization of nanoparticles. Journal Of Immunological Methods 2024, 528: 113668. PMID: 38574804, PMCID: PMC11023749, DOI: 10.1016/j.jim.2024.113668.Peer-Reviewed Original ResearchConceptsDeposition of C3Complement activation markersSurface C3 depositionMembrane attack complex C5b-9Activation markersDot blot immunoassayC3 depositionAnaphylatoxins C3aImmune responseNanomedicine researchC5b-9Complement attackComplement activationBlot immunoassayFluid phase markerMarkersPhase markersImmunoassaySurface resultsPathway specificityAssembly of C3 convertaseComplementNanoparticles
2023
Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA Nephropathy
Kang Y, Xu B, Shi S, Zhou X, Chen P, Liu L, Li Y, Leng Y, Lv J, Zhu L, Zhang H. Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA Nephropathy. Clinical Journal Of The American Society Of Nephrology 2023, 18: 1583-1591. PMID: 37651123, PMCID: PMC10723908, DOI: 10.2215/cjn.0000000000000290.Peer-Reviewed Original ResearchConceptsMesangial C3 depositionGenome-wide association studiesIgA nephropathyComplement factor HC3 depositionGenotype-phenotype correlationIntensity of C3 depositionAssociation studiesLong-term kidney outcomesSusceptibility variantsProgression of IgA nephropathySevere clinical phenotypeKaplan-Meier analysisDeposition of IgAIgA nephropathy cohortIgA nephropathy progressionComplement component 3Chi-square testPrimary GNClinical phenotypeKidney outcomesFactor HGenotypesChinese patientsComplement regulatorsClinical and pathological characteristics in elderly patients with IgA nephropathy
Zhang Y, Li Q, Shi S, Liu L, Lv J, Zhu L, Zhang H. Clinical and pathological characteristics in elderly patients with IgA nephropathy. Clinical Kidney Journal 2023, 16: 1974-1979. PMID: 37915928, PMCID: PMC10616429, DOI: 10.1093/ckj/sfad203.Peer-Reviewed Original ResearchIgAN patientsElderly patientsP16<sup>INK4a</sup> stainingTime of renal biopsyRenal tubulesLevels of circulating IgACause of primary glomerulonephritisUrinary protein levelsAssociated with T-scoreImmunoglobulin A nephropathyAssociated with eGFRBlood cell countIncidence of hypertensionDegree of IgAProdromal infectionIgAN cohortIncidence of IgANPlatelet countRenal biopsyLymphocyte countRed blood cell countPrimary glomerulonephritisPathological characteristicsIgA nephropathyC3 deposition
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