2022
Downregulation of Sirt6 by CD38 promotes cell senescence and aging
Zhou H, Liu S, Zhang N, Fang K, Zong J, An Y, Chang X. Downregulation of Sirt6 by CD38 promotes cell senescence and aging. Aging 2022, 14: 9730-9757. PMID: 36490326, PMCID: PMC9792202, DOI: 10.18632/aging.204425.Peer-Reviewed Original ResearchConceptsCD38 expressionSIRT6 expressionC3GCD38 siRNACell senescenceIncreased SIRT6 expressionMechanism of CD38H9c2 cellsInduced to senescenceTelomerase reverse transcriptase levelsReverse transcriptase levelsNK cell levelsPresence of C3GNicotinamide adenine dinucleotidePromote cell senescenceReduced reactive oxygen speciesTNF-a levelsDecreased SIRT6 expressionReactive oxygen speciesD-gal induced senescenceHexokinase 2OSS-128167Myocardial H9c2 cellsStimulate cell proliferationSiRNA
2019
Outcome of C3 glomerulopathy patients: largest single-centre experience from South Asia
Kumar A, Nada R, Ramachandran R, Rawat A, Tiewsoh K, Das R, Rayat C, Gupta K, Vasishta R. Outcome of C3 glomerulopathy patients: largest single-centre experience from South Asia. Journal Of Nephrology 2019, 33: 539-550. PMID: 31820418, DOI: 10.1007/s40620-019-00672-5.Peer-Reviewed Original ResearchConceptsAlternative complement pathwayC3G patientsPost-transplant recurrenceSingle-centre experienceMajority of patientsGenetic profileHistory of infectionComplement factor HLevels of C3C3 nephritic factorBackgroundC3 glomerulopathyPartial remissionC3GG patientsResistant diseaseGenetic workupMonoclonal paraproteinRenal transplantationAutoantibody testingC3 levelsClinical detailsMonoclonal immunoglobulinFollow-upPathogenic variantsHistopathological profile
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