2024
Association Between High-Sensitivity Troponin (hs-cTnT) and Diagnosis of Myocarditis in Previously Healthy Pediatric Patients
Degen M, Leviter J, Bradley A, Karnik R, Ferdman D, McCollum S, Faherty E. Association Between High-Sensitivity Troponin (hs-cTnT) and Diagnosis of Myocarditis in Previously Healthy Pediatric Patients. Pediatric Cardiology 2024, 1-7. PMID: 39126513, DOI: 10.1007/s00246-024-03621-7.Peer-Reviewed Original ResearchDiagnosis of myocarditisPediatric patientsHs-cTnTTroponin levelsCardiac diagnosisHigh-sensitivity troponin THealthy pediatric patientsHigh-sensitivity troponinHs-cTnT groupMedian peak levelSensitivity troponin levelsElevated hs-cTnTCut-off valueInitial troponin levelMyocarditis diagnosisAcute myocarditisTroponin valuesCardiac troponinPediatric populationTroponin TMyocarditisPatientsPeak levelsDiagnosisMyocardial tissue
2021
COVID-19 vaccine – Long term immune decline and breakthrough infections
Khoury J, Najjar-Debbiny R, Hanna A, Jabbour A, Abu Ahmad Y, Saffuri A, Abu-Sinni M, Shkeiri R, Elemy A, Hakim F. COVID-19 vaccine – Long term immune decline and breakthrough infections. Vaccine 2021, 39: 6984-6989. PMID: 34763949, PMCID: PMC8556595, DOI: 10.1016/j.vaccine.2021.10.038.Peer-Reviewed Original ResearchConceptsAntibody titersCOVID-19 vaccineBreakthrough infectionsSecond doseAntibody levelsPolymerase chain reactionBNT162b2 mRNA COVID-19 vaccineSARS-CoV-2 polymerase chain reactionMRNA COVID-19 vaccineStudy periodBreakthrough infection rateMedian antibody levelsMean antibody levelsLongitudinal prospective studyAntibody declineTiter elevationImmune declineProspective studyClinical indicationsMild casesHealthcare personnelInfection rateInfectionVaccinePeak levelsHuman IgG and IgA responses to COVID-19 mRNA vaccines
Wisnewski AV, Luna J, Redlich CA. Human IgG and IgA responses to COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0249499. PMID: 34133415, PMCID: PMC8208542, DOI: 10.1371/journal.pone.0249499.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccinesAntigen-specific IgGMRNA vaccinesIgG levelsCOVID-19 mRNA vaccinationAntigen-specific IgG levelsInitial vaccine doseAntigen-specific IgASARS-CoV-2More rapid declineSecond vaccineVaccine doseMRNA vaccinationIgA responsesSerum levelsVaccine dosesSpecific IgGNatural immunityViral neutralizationIgAVaccinePeak levelsIgGVaccinationHuman IgG
2013
Nicotine Levels After IV Nicotine and Cigarette Smoking in Men
Mello NK, Peltier MR, Duncanson H. Nicotine Levels After IV Nicotine and Cigarette Smoking in Men. Experimental And Clinical Psychopharmacology 2013, 21: 188-195. PMID: 23647094, PMCID: PMC9086919, DOI: 10.1037/a0031799.Peer-Reviewed Original ResearchConceptsHigh-nicotine cigarettesCigarette smokingNicotine levelsPeak levelsTime courseNicotine-dependent menVisual analog scale ratingsPlasma nicotine levelsLow nicotine cigarettesDoses of nicotinePharmacokinetics of nicotineSimilar time courseNicotine administrationNicotine dosePlasma nicotineVAS ratingsSmokingNicotineSubjective effectsMore hrCigarettesDosesScale ratingsSubjective reportsDose
2005
Phase I Study of the Sequential Combination of Interleukin-12 and Interferon Alfa-2b in Advanced Cancer: Evidence for Modulation of Interferon Signaling Pathways by Interleukin-12
Eisenbeis CF, Lesinski GB, Anghelina M, Parihar R, Valentino D, Liu J, Nadella P, Sundaram P, Young DC, Sznol M, Walker MJ, Carson WE. Phase I Study of the Sequential Combination of Interleukin-12 and Interferon Alfa-2b in Advanced Cancer: Evidence for Modulation of Interferon Signaling Pathways by Interleukin-12. Journal Of Clinical Oncology 2005, 23: 8835-8844. PMID: 16314644, DOI: 10.1200/jco.2005.02.1691.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsDose-Response Relationship, DrugHumansInterferon alpha-2Interferon-alphaInterferon-gammaInterleukin-12Leukocytes, MononuclearMiddle AgedNeoplasmsRecombinant ProteinsSignal TransductionSTAT1 Transcription FactorTime FactorsTreatment OutcomeConceptsPatients' peripheral blood mononuclear cellsPatient PBMCsInterferon alfa-2bIFN-gammaInterleukin-12Alfa-2bRhIL-12Advanced cancerIL-12Greater IFN-gamma productionPeripheral blood mononuclear cellsPeak levelsIL-12 administrationPlasma IFN-gammaIL-12 therapyDose-limiting toxicityIFN-gamma productionHuman interleukin-12Interferon Signaling PathwayAssessable patientsIntracellular STAT1Stable diseasePeripheral bloodMononuclear cellsLevels of STAT1
2004
Sil overexpression in lung cancer characterizes tumors with increased mitotic activity
Erez A, Perelman M, Hewitt SM, Cojacaru G, Goldberg I, Shahar I, Yaron P, Muler I, Campaner S, Amariglio N, Rechavi G, Kirsch IR, Krupsky M, Kaminski N, Izraeli S. Sil overexpression in lung cancer characterizes tumors with increased mitotic activity. Oncogene 2004, 23: 5371-5377. PMID: 15107824, DOI: 10.1038/sj.onc.1207685.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBlotting, WesternCell DifferentiationCell DivisionCell LineG1 PhaseGenes, Immediate-EarlyHeLa CellsHumansImmunohistochemistryIntracellular Signaling Peptides and ProteinsKinetochoresLung NeoplasmsMitosisNeoplasm MetastasisOligonucleotide Array Sequence AnalysisOncogene Proteins, FusionRNA, MessengerConceptsLung cancerT-cell acute lymphoblastic leukemiaMitotic activityAcute lymphoblastic leukemiaLung cancer samplesPrimary adenocarcinomaLymphoblastic leukemiaMetastatic spreadImmediate early genesMicroarray gene expression analysisTissue arraysPeak levelsCancer samplesProtein expressionTumorsCancerProtein levelsCell proliferationMitotic indexCommon chromosomal rearrangementsGene expression analysisSIL geneEarly genesOverexpressionRecent studies
2002
Population variation in age-related decline in male salivary testosterone
Ellison P, Bribiescas R, Bentley G, Campbell B, Lipson S, Panter-Brick C, Hill K. Population variation in age-related decline in male salivary testosterone. Human Reproduction 2002, 17: 3251-3253. PMID: 12456632, DOI: 10.1093/humrep/17.12.3251.Peer-Reviewed Original ResearchClaudin 5 Is Transiently Expressed During the Development of the Retinal Pigment Epithelium
Kojima S, Rahner C, Peng S, Rizzolo L. Claudin 5 Is Transiently Expressed During the Development of the Retinal Pigment Epithelium. The Journal Of Membrane Biology 2002, 186: 81-88. PMID: 11944085, DOI: 10.1007/s00232-001-0137-7.Peer-Reviewed Original ResearchConceptsReverse transcriptase-polymerase chain reactionRetinal pigment epitheliumClaudin-5Chick retinal pigment epitheliumPigment epitheliumTranscriptase-polymerase chain reactionEmbryonic day 14Tight junctionsSemiquantitative RT-PCRExpression of claudinsEmbryonic day 10Northern blottingNeural retinaDay 14Semi-quantitative RT-PCRDay 10Claudin-3RPE developmentPeak levelsDay 7 embryosChoroid layerPrimary culturesChain reactionEpitheliumBlotting
1999
Interferon-γ effects on activities of gentamicin and vancomycin against Enterococcus faecalis resistant to the drugs: an in vitro study with human neutrophils
Onyeji C, Nicolau D, Nightingale C, Bow L. Interferon-γ effects on activities of gentamicin and vancomycin against Enterococcus faecalis resistant to the drugs: an in vitro study with human neutrophils. International Journal Of Antimicrobial Agents 1999, 11: 31-37. PMID: 10075275, DOI: 10.1016/s0924-8579(98)00085-5.Peer-Reviewed Original ResearchConceptsIFN-gammaHuman neutrophilsMajor therapeutic challengeMultidrug-resistant E. faecalisAnti-enterococcal activityEffective antimicrobial therapyMultidrug-resistant enterococciActivity of gentamicinPotential underlying mechanismsEnterococcus faecalisTherapeutic troughMaximal growth inhibitionTherapeutic challengeSerum troughReactive oxygen intermediatesAntimicrobial therapyUseful adjunctClinical isolatesActivated secretionNeutrophilsPeak levelsGentamicinVancomycinPeak concentrationE. faecalis
1998
Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia
Aufricht C, Ardito T, Thulin G, Kashgarian M, Siegel N, Van Why S. Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia. American Journal Of Physiology 1998, 274: f215-f222. PMID: 9458842, DOI: 10.1152/ajprenal.1998.274.1.f215.Peer-Reviewed Original ResearchConceptsHSP-25Renal ischemiaHeat shock protein 25Ischemic renal injuryH reflowRat renal cortexControl proximal tubulesRenal injuryPostischemic recoveryRenal cortexIschemiaProximal tubulesIntracytoplasmic accumulationPeak levelsHeat shock proteinsProtein 25Actin stainingInsoluble cytoskeletal fractionPunctate accumulationsCytoskeletal disruptionSmall heat shock proteinsRegulatory roleInductionIntracellular distributionCytoskeletal fraction
1995
Activities of Clarithromycin, Azithromycin, and Ofioxacin in Combination with Liposomal or Unencapsulated Granulocyte-Macrophage Colony-Stimulating Factor against Intramacrophage Mycobacterium avium-Mycobacterium intracellulare
Onyeji C, Nightingale C, Tessier P, Nicolau D, Bow L. Activities of Clarithromycin, Azithromycin, and Ofioxacin in Combination with Liposomal or Unencapsulated Granulocyte-Macrophage Colony-Stimulating Factor against Intramacrophage Mycobacterium avium-Mycobacterium intracellulare. The Journal Of Infectious Diseases 1995, 172: 810-816. PMID: 7658075, DOI: 10.1093/infdis/172.3.810.Peer-Reviewed Original ResearchConceptsMycobacterium avium-Mycobacterium intracellulareGranulocyte-macrophage colony-stimulating factorColony-stimulating factorGM-CSFHuman macrophage infection modelMaximal killing effectTherapeutic peak concentrationsTherapeutic trough concentrationsActivity of clarithromycinEffects of ofloxacinMacrophage infection modelMAI infectionTrough concentrationsSerum troughUseful adjunctClarithromycinAzithromycinInfection modelPeak levelsSignificant augmentationKilling effectPeak concentrationOfloxacinAntimycobacterial activityIntracellulare
1973
Physiologic disposition of 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea (CCNU) and 1‐(2‐chloroethyl)‐3‐(4‐methyl cyclohexyl)‐1‐nitrosourea (MeCCNU) in man
Sponzo R, Devita V, Oliverio V. Physiologic disposition of 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea (CCNU) and 1‐(2‐chloroethyl)‐3‐(4‐methyl cyclohexyl)‐1‐nitrosourea (MeCCNU) in man. Cancer 1973, 31: 1154-1159. PMID: 4705152, DOI: 10.1002/1097-0142(197305)31:5<1154::aid-cncr2820310517>3.0.co;2-b.Peer-Reviewed Original Research
1970
The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow
Boyer J, Scheig R, Klatskin G. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow. Journal Of Clinical Investigation 1970, 49: 206-215. PMID: 5411780, PMCID: PMC322462, DOI: 10.1172/jci106229.Peer-Reviewed Original ResearchConceptsBile salt excretionBSP TmBile flowBile productionBiliary concentrationHepatic metabolismBile saltsBiliary bile salt excretionSalt excretionSulfobromophthalein sodiumSodium taurocholateMug/minSodium taurocholate infusionBile salt infusionBSP transportCholeretic propertiesSaline infusionTaurocholate infusionIndependent factorsConstant infusionHepatic uptakeMumoles/hrInfusionMul/minPeak levels
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