2023
Low Dose Total Body Irradiation Improves CD19 CAR-T Expansion, Persistence, and Trafficking, Leading to Enhanced Efficacy in Large B-Cell Lymphoma
Alhomoud M, Foley M, Sugita M, Yamazaki T, Martinez L, Yamshon S, Gomez-Arteaga A, Pagnini P, Shore T, Boyer O, Brentjens R, Van Besien K, Galluzzi L, Formenti S, Martinet J, Guzman M. Low Dose Total Body Irradiation Improves CD19 CAR-T Expansion, Persistence, and Trafficking, Leading to Enhanced Efficacy in Large B-Cell Lymphoma. Blood 2023, 142: 1016. DOI: 10.1182/blood-2023-185216.Peer-Reviewed Original ResearchLow-dose total body irradiationLarge B-cell lymphomaDose total body irradiationTotal body irradiationSyngeneic mouse modelB-cell lymphomaComplete remissionDays post treatmentExpression of FasBody irradiationSecond dosePeripheral bloodGy radiationMouse modelAnti-CD19 Chimeric Antigen Receptor T CellsA20 cellsChimeric antigen receptor T cellsAntigen receptor T cellsBALB/c miceB-cell recoveryAdditional survival benefitB-cell aplasiaReceptor T cellsImmunosuppressive tumor microenvironmentBone marrow aspirate
2020
Cell-Penetrable Peptide-Conjugated FADD Induces Apoptosis and Regulates Inflammatory Signaling in Cancer Cells
Ranjan K, Waghela BN, Vaidya FU, Pathak C. Cell-Penetrable Peptide-Conjugated FADD Induces Apoptosis and Regulates Inflammatory Signaling in Cancer Cells. International Journal Of Molecular Sciences 2020, 21: 6890. PMID: 32961826, PMCID: PMC7555701, DOI: 10.3390/ijms21186890.Peer-Reviewed Original ResearchConceptsFADD proteinCancer cellsAnti-apoptotic genesCaveolar pathwayDeath domainCellular pathwaysCancer cell proliferationCytosolic expressionFADD expressionCell deathApoptosis inducersInduces ApoptosisExpression of FasProteinCell proliferationApoptosisNF-κB activationSimultaneous regulationInflammatory signalingExpressionCellsNLRP3 inflammasome primingRegulationPathwayInflammasome priming
2007
Role of Fas in Autoimmune Diabetes (128.30)
Mora C, Wen L, Gomis R, Green E, Chervonsky A, Wong F, García A, Flavell R. Role of Fas in Autoimmune Diabetes (128.30). The Journal Of Immunology 2007, 178: s216-s216. DOI: 10.4049/jimmunol.178.supp.128.30.Peer-Reviewed Original ResearchCD4 T cellsNOD miceΒ-cellsΒ-cell deathRole of FasAutoimmune diabetesIL-1βT cellsDiabetogenic CD4 T cellsDevelopment of diabetesCytokine-mediated inductionMouse β-cellsCell deathExpression of FasIslet antigensDiabetes incidenceImmune toleranceKey cytokineDiabetic phenotypeEarly overexpressionDiabetesIslet cellsFAS expressionFasL overexpressionMice
2006
Involvement of the Fas–Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell–only syndrome
Kim S, Yoon Y, Park Y, Seo J, Kim J. Involvement of the Fas–Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell–only syndrome. Fertility And Sterility 2006, 87: 547-553. PMID: 17123522, DOI: 10.1016/j.fertnstert.2006.07.1524.Peer-Reviewed Original ResearchConceptsMaturation arrestActive caspase-3Sertoli cellsCaspase-3Testicular expressionDUTP nick end labeling stainingCases of SCOTerminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) stainingNick end labeling stainingTransferase-mediated dUTP nick-end labeling stainingTesticular biopsy specimensTestes of patientsGerm cellsTranscription-polymerase chain reactionFas-Fas ligand systemRoutine clinical purposesHyperplastic interstitial cellsExpression of FasLExpression of FasBiopsy specimensMAIN OUTCOMEObstructive azoospermiaImmunohistochemical analysisIntense immunostainingLabeling staining
2000
Roles of Fas and Fas ligand during mammary gland remodeling
Song J, Sapi E, Brown W, Nilsen J, Tartaro K, Kacinski B, Craft J, Naftolin F, Mor G. Roles of Fas and Fas ligand during mammary gland remodeling. Journal Of Clinical Investigation 2000, 106: 1209-1220. PMID: 11086022, PMCID: PMC381435, DOI: 10.1172/jci10411.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternCaspase 3CaspasesCell LineCulture MediaCulture Media, Serum-FreeDexamethasoneEpithelial CellsFas Ligand Proteinfas ReceptorFemaleGene ExpressionHumansMammary Glands, AnimalMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred MRL lprMice, KnockoutPregnancyPregnancy, AnimalRNA, MessengerConceptsMammary epithelial cellsFas/FasL signalsMouse mammary epithelial cellsMammary gland remodelingFasL proteinApoptotic cellsEpithelial cellsInduction of apoptosisAccumulation of cellsSubsequent neoplastic developmentRole of FasMammary gland tissueFasL signalsMammary tissueCell deathExpression of FasFas-FasL interactionMouse mammary tissueMammary cellsCaspase-3Autocrine inductionFas ligandMammary epitheliumNeoplastic developmentTumor development
1998
Fas LIGAND, TUMOR NECROSIS FACTOR-α EXPRESSION, AND APOPTOSIS DURING ALLOGRAFT REJECTION AND TOLERANCE
Josien R, Müschen M, Gilbert E, Douillard P, Heslan J, Soulillou J, Cuturi M. Fas LIGAND, TUMOR NECROSIS FACTOR-α EXPRESSION, AND APOPTOSIS DURING ALLOGRAFT REJECTION AND TOLERANCE. Transplantation 1998, 66: 887-893. PMID: 9798699, DOI: 10.1097/00007890-199810150-00013.Peer-Reviewed Original ResearchConceptsAllograft rejectionTNF-alphaDonor-specific blood transfusionApoptotic cellsNecrosis factor α expressionRole of CD95LAcute allograft rejectionDonor-specific transfusionGraft-infiltrating cellsHeterotopic cardiac allograftsCytotoxic T cellsTarget cell lysisTNF-alpha expressionTumor necrosis factorExpression of CD95LCD95/CD95LExpression of FasAcute rejectionCardiac allograftsBlood transfusionIntragraft expressionNecrosis factorT cellsCD95 antigenAllografts
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