2023
Qualitative Point-of-Care Ultrasound Enema Management for Constipation
Riera A, Phatak U. Qualitative Point-of-Care Ultrasound Enema Management for Constipation. Pediatric Emergency Care 2023, 40: 239-242. PMID: 37890187, DOI: 10.1097/pec.0000000000003081.Peer-Reviewed Original ResearchPediatric emergency departmentEmergency departmentEnema administrationCare ultrasound findingsStool burdenHard stoolsPresenting symptomUltrasound findingsCare ultrasoundConstipationAdministrationFinal dispositionDepartmentMost casesStoolActive problemLanguage barriersRectumSymptomsCasesQualitative evaluation
2022
61. Clinical whole exome/whole transcriptome analysis detects clinically relevant structural alterations in Multiple Myeloma
Calvo M, Caruthers S, Tripodi J, Houldsworth J, Fink M, Newman S, Chen R, Zhang W, Liu L, Shi Y, Jun T, Onel K, Oh W, Edelmann L, Schadt E, Rossi M, Hantash F, Al-Kateb H. 61. Clinical whole exome/whole transcriptome analysis detects clinically relevant structural alterations in Multiple Myeloma. Cancer Genetics 2022, 268: 20. DOI: 10.1016/j.cancergen.2022.10.064.Peer-Reviewed Original ResearchChromosomal copy number alterationsMolecular alterationsManagement of patientsPlasma cell contentDeletion of 13qMM patientsRisk stratificationMultiple myelomaOverexpression of CCND1Bi-allelic inactivationCopy number alterationsPatientsRelevant alterationsMolecular analysisRNA expression analysisNumber alterationsBuccal swabsAlterationsStructural alterationsCell contentMost casesGene fusionsCD138MyelomaCasesGeneralizing Trial Evidence to Target Populations in Non-Nested Designs: Applications to AIDS Clinical Trials
Li F, Buchanan AL, Cole SR. Generalizing Trial Evidence to Target Populations in Non-Nested Designs: Applications to AIDS Clinical Trials. Journal Of The Royal Statistical Society Series C (Applied Statistics) 2022, 71: 669-697. PMID: 35968541, PMCID: PMC9367209, DOI: 10.1111/rssc.12550.Peer-Reviewed Original ResearchAIDS Clinical Trials GroupTarget populationClinical Trials GroupComparative effectiveness evidenceTreatment effectsRandomized trialsTrial evidenceClinical trialsTrial groupHIV interventionsACTG trialsTrial participantsTrial designPropensity scoreEffectiveness evidenceTrialsAIDS clinical trialsSpecified populationPopulationAverage treatment effectMost casesHIVEvidenceRegression
2021
Ultrasound-assisted Lumbar Puncture for Obese Pediatric Oncology Patients: A Feasibility Study
Leviter J, Kadan-Lottick NS, Auerbach C, Riera A. Ultrasound-assisted Lumbar Puncture for Obese Pediatric Oncology Patients: A Feasibility Study. Journal Of Pediatric Hematology/Oncology 2021, 44: 438-441. PMID: 34862351, DOI: 10.1097/mph.0000000000002362.Peer-Reviewed Original ResearchConceptsPediatric oncology patientsLumbar punctureOncology patientsStandard of carePediatric oncology providersSuccessful lumbar punctureDelivery of careUltrasound-assisted lumbar punctureLP successOncology providersDeep sedationHigh success rateCare ultrasoundTherapeutic interventionsPatientsPromising modalitySuccess rateLP procedurePunctureCarePromising strategyMost casesLow numberObesitySedation
2020
The Unintended Consequences of Nonoperative Management of Acute Appendicitis
Oliveira K, Jean RA, Gonsai R, Maduka RC, Gibson CE, Chiu AS, Ahuja V. The Unintended Consequences of Nonoperative Management of Acute Appendicitis. Journal Of Surgical Research 2020, 255: 436-441. PMID: 32619858, DOI: 10.1016/j.jss.2020.05.018.Peer-Reviewed Original ResearchConceptsNonoperative managementAcute appendicitisNational Readmission DatabaseOdds of readmissionCause readmission rateRisk of readmissionTraditional operative approachMultivariable linear regressionMore comorbiditiesIndex hospitalizationReadmission ratesSurgical managementAdult admissionsOperative approachPatient burdenAppendicitisPatientsSix monthsAppendectomyReadmissionSignificant increaseMost casesLinear regressionManagementComorbiditiesScarce-Resource Allocation and Patient Triage During the COVID-19 Pandemic JACC Review Topic of the Week
Kirkpatrick JN, Hull SC, Fedson S, Mullen B, Goodlin SJ. Scarce-Resource Allocation and Patient Triage During the COVID-19 Pandemic JACC Review Topic of the Week. Journal Of The American College Of Cardiology 2020, 76: 85-92. PMID: 32407772, PMCID: PMC7213960, DOI: 10.1016/j.jacc.2020.05.006.Peer-Reviewed Original ResearchConceptsBest possible careHealth care systemPrognostic factorsPalliative careBedside cliniciansPatient triageMedical appropriatenessPossible careCare systemDifficult decisionsCrisis standardsScarce medical resourcesReview TopicMedical resourcesUnique considerationsCOVID-19 pandemicTriageCareClear communicationMedical knowledgeMost casesPandemicSequelaePatientsResuscitation
2019
Identification of a novel MYOC variant in a Hispanic family with early-onset primary open-angle glaucoma with elevated intraocular pressure
Criscione J, Ji W, Jeffries L, McGrath JM, Soloway S, Pusztai L, Lakhani S. Identification of a novel MYOC variant in a Hispanic family with early-onset primary open-angle glaucoma with elevated intraocular pressure. Molecular Case Studies 2019, 5: a004374. PMID: 31653660, PMCID: PMC6913140, DOI: 10.1101/mcs.a004374.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaEarly-onset primary open-angle glaucomaOpen-angle glaucomaGenetic testingElevated intraocular pressureJuvenile-onset primary open-angle glaucomaFurther genetic testingAutosomal dominant patternFemale patientsIntraocular pressureIrreversible blindnessFamily historyEye disordersMYOC variantsMyocilin geneGlaucomaPOAG phenotypeHispanic familiesOlfactomedin domainPrevious findingsDominant patternVariant segregatesMost casesPatientsEtiologyCervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL. Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2019, 17: 64-84. PMID: 30659131, DOI: 10.6004/jnccn.2019.0001.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsBrachytherapyCervix UteriChemoradiotherapy, AdjuvantFemaleFertility PreservationHumansHysterectomyMass ScreeningMedical OncologyNeoplasm StagingOrgan Sparing TreatmentsPapanicolaou TestPapillomaviridaePapillomavirus InfectionsSocieties, MedicalUnited StatesUterine Cervical NeoplasmsConceptsCervical cancerHuman papilloma virus vaccinationNCCN Clinical Practice GuidelinesTreatment of recurrentAdvanced cervical cancerClinical practice guidelinesMalignant epithelial tumorsNCCN guidelinesMetastatic diseaseVirus vaccinationUterine cervixCommon cancerPrecancerous lesionsFull guidelinePractice guidelinesEpithelial tumorsRoutine screeningCancerScreening protocolTreatmentGuidelinesMost casesEarly stagesCervixVaccination
2018
Ischemic Colitis
Johnson D, Davis K. Ischemic Colitis. 2018, 311-323. DOI: 10.1007/978-3-319-96286-3_26.Peer-Reviewed Original ResearchMultisystem organ failureIschemic colitisAcute lower GIReversible clinical symptomsSevere ischemic colitisCardiac eventsPostoperative periodCardiac surgeryOrgan failureAnnual incidenceIschemic injuryClinical symptomsCommon subtypeTransmural necrosisGastrointestinal tractLower GIPatientsColitisPopulation agesCommon formMost casesSurgeryEtiologyInjurySymptomsA Large Leptospirosis Outbreak following Successive Severe Floods in Fiji, 2012.
Togami E, Kama M, Goarant C, Craig SB, Lau C, Ritter JM, Imrie A, Ko A, Nilles EJ. A Large Leptospirosis Outbreak following Successive Severe Floods in Fiji, 2012. American Journal Of Tropical Medicine And Hygiene 2018, 99: 849-851. PMID: 30141390, PMCID: PMC6159581, DOI: 10.4269/ajtmh.18-0335.Peer-Reviewed Original ResearchTreatment of Neurological Symptoms in Wilson Disease
Vives-Rodriguez A, Robakis D, Bamford N. Treatment of Neurological Symptoms in Wilson Disease. Clinical Gastroenterology 2018, 107-120. DOI: 10.1007/978-3-319-91527-2_6.Peer-Reviewed Original ResearchNeurological symptomsWilson's diseaseNeurological manifestationsTherapeutic optionsMovement disordersCommon neurological manifestationsDifferent therapeutic optionsResidual neurological symptomsUse of medicationsBrain copper accumulationQuality of lifeGait impairmentPartial improvementNeurological aspectsSymptomsDiseaseDisordersManifestationsCopper accumulationMost casesMedicationsDystoniaParkinsonismPatientsOptionsCommon PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection
Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A. Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell 2018, 173: 443-455.e12. PMID: 29576450, PMCID: PMC5889333, DOI: 10.1016/j.cell.2018.02.047.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnemia, Hemolytic, CongenitalAnimalsBlack PeopleDehydrationDisease Models, AnimalErythrocytesGene DeletionGenotypeHumansHydrops FetalisIntermediate-Conductance Calcium-Activated Potassium ChannelsIon ChannelsMalariaMiceMice, Inbred C57BLMice, KnockoutPhenotypePlasmodium bergheiT-LymphocytesConceptsPlasmodium infectionRBC dehydrationRed blood cell dehydrationExperimental cerebral malariaRare genetic conditionHereditary xerocytosisCerebral malariaMouse modelMild hemolysisAfrican populationsInfectionMalaria resistanceGenetic conditionsFunction mutationsMalariaIon channelsRBCsPiezo1Most casesE756delAllelesCell dehydrationHigh frequencyPopulationXerocytosis
2016
Chapter 1 An Introduction to Clinical Research Concepts
Nadkarni P. Chapter 1 An Introduction to Clinical Research Concepts. 2016, 1-24. DOI: 10.1016/b978-0-12-803130-8.00001-4.Peer-Reviewed Original Research
2015
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?
Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2015, 31: 454-458. PMID: 26481763, DOI: 10.1002/jca.21429.Peer-Reviewed Original ResearchConceptsExchange transfusionHigh-risk populationLife-threatening illnessApparent therapeutic benefitBlood transfusionModerate diseaseClinical presentationAsymptomatic infectionSevere babesiosisSevere diseaseRisk populationsTherapeutic benefitTransfusionMortality rateIntraerythrocytic protozoan parasiteBabesia infectionDiseaseIxodes ticksProtozoan parasiteBabesiosisInfectionGenus BabesiaMost casesPatientsClindamycinBabesiosis
Vannier EG, Diuk-Wasser MA, Mamoun C, Krause PJ. Babesiosis. Infectious Disease Clinics Of North America 2015, 29: 357-370. PMID: 25999229, PMCID: PMC4458703, DOI: 10.1016/j.idc.2015.02.008.Peer-Reviewed Original ResearchToscana Virus Encephalitis in a Traveler Returning to the United States
Howell BA, Azar MM, Landry ML, Shaw AC. Toscana Virus Encephalitis in a Traveler Returning to the United States. Journal Of Clinical Microbiology 2015, 53: 1445-1447. PMID: 25673791, PMCID: PMC4365192, DOI: 10.1128/jcm.03498-14.Peer-Reviewed Case Reports and Technical Notes
2013
Does Kidney Disease Cause Hypertension?
Peixoto AJ, Orias M, Desir GV. Does Kidney Disease Cause Hypertension? Current Hypertension Reports 2013, 15: 89-94. PMID: 23344662, DOI: 10.1007/s11906-013-0327-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseKidney diseaseRenal functionStructural kidney diseaseGlomerular filtration ratePlasmin-mediated activationExtracellular fluid volumeProteinuric glomerular diseasesPolycystic kidney diseaseChronic hypertensionHypertension increasesEpithelial sodium channelSodium retentionFiltration rateGlomerular diseaseHypertensionCurrent evidenceDiseaseSodium channelsFluid volumeDetectable changeSevere reductionMost casesProteinuriaPatients
2012
Internal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex?
Rodriguez L, Siddiqui A, Nurko S. Internal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex? Neurogastroenterology & Motility 2012, 24: 1023-e545. PMID: 22757618, PMCID: PMC3465462, DOI: 10.1111/j.1365-2982.2012.01965.x.Peer-Reviewed Original ResearchConceptsHigh-amplitude peristaltic contractionsInternal anal sphincter relaxationAnal sphincter relaxationIAS relaxationSphincter relaxationAnal residual pressureManometry tracingsDefecation disordersConstipated childrenAnal relaxationHepatic flexureResting pressureDistal colonPeristaltic contractionsColonAbstractTextConstipationContraction propagationReflexChildrenImportant proportionContractionMost casesPatientsBisacodylHuman herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma
Siddon A, Lozovatsky L, Mohamed A, Hudnall SD. Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma. British Journal Of Haematology 2012, 158: 635-643. PMID: 22757777, DOI: 10.1111/j.1365-2141.2012.09206.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedBlotting, WesternCell Line, TumorDNA, ViralEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHerpesvirus 6, HumanHodgkin DiseaseHumansImmunohistochemistryLymphoma, FollicularMaleMiddle AgedPolymerase Chain ReactionReed-Sternberg CellsRoseolovirus InfectionsSclerosisYoung AdultConceptsNodular sclerosis Hodgkin lymphomaNodular sclerosis HLHHV-6 DNAEpstein-Barr virusHHV-6Hodgkin's lymphomaReed-Sternberg cellsPolymerase chain reactionRS cellsNSHL casesEBV-negative diseaseReactive lymphoid hyperplasiaClassical Hodgkin lymphomaBi-modal age distributionHHV-6 genomeYounger patientsInfectious etiologyLymphoid hyperplasiaPCR positivityYounger ageImmunohistochemistryMost casesConflicting resultsChain reactionCD30Evaluation and management of voiding dysfunction after midurethral sling procedures
Celik H, Harmanlı O. Evaluation and management of voiding dysfunction after midurethral sling procedures. Journal Of The Turkish-German Gynecological Association 2012, 13: 123-127. PMID: 24592021, PMCID: PMC3939134, DOI: 10.5152/jtgga.2012.14.Peer-Reviewed Original ResearchStress urinary incontinenceUrinary incontinenceRecurrent stress urinary incontinenceObstructive voiding symptomsPartial urethral obstructionMidurethral sling proceduresPopular surgical procedureTape mobilizationUrinary retentionVoiding symptomsConservative treatmentMidurethral slingSling procedureIncontinence treatmentUrethral obstructionSurgical proceduresIncontinenceDysfunctionSymptomsTreatmentMost casesUrethrolysisPatientsUrethraObstruction
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