2019
Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients
Kukova LZ, Mansour SG, Coca SG, de Fontnouvelle CA, Thiessen-Philbrook HR, Shlipak MG, El-Khoury JM, Parikh CR. Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients. The Journal Of Applied Laboratory Medicine 2019, 4: 331-342. PMID: 31659071, DOI: 10.1373/jalm.2018.028621.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsSurgery patientsCardiac surgeryBiomarker concentrationsAcute kidney injuryComparison of urinePlasma biomarker concentrationsImmunoassay methodPostoperative biomarkersPostoperative plasmaPreoperative biomarkersKidney injuryInjury cohortBiomarker discoveryBiomarker endpointsClinical settingCurrent immunoassay methodsBiomarker valuesUrine samplesTranslational researchUrineSpearman correlationPaired samplesPatientsSurgery
2018
Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study
Meisner A, Kerr KF, Thiessen-Philbrook H, Wilson FP, Garg AX, Shlipak MG, Kavsak P, Whitlock RP, Coca SG, Parikh CR. Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study. Biomarker Research 2018, 6: 3. PMID: 29344362, PMCID: PMC5767010, DOI: 10.1186/s40364-018-0117-z.Peer-Reviewed Original ResearchCardiopulmonary bypass timeMild AKISevere AKICardiac surgeryBiomarker combinationsBypass timeKidney injurySerum creatininePostoperative acute kidney injuryB-type natriuretic peptideAcute kidney injuryBackgroundAcute kidney injuryHeart-type fatty acidMethodsThe primary endpointSerum creatinine increaseMulticenter cohort studyPlasma interleukin-6Optimism-corrected AUCPostoperative biomarkersCreatinine increaseHospital stayPrimary endpointPreoperative levelsCohort studyFrequent complication
2017
Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery
Lin H, Scherzer R, Philbrook HT, Coca SG, Wilson FP, Garg AX, Shlipak MG, Parikh CR. Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery. Biomarkers In Medicine 2017, 11: 1091-1102. PMID: 29172665, PMCID: PMC5753615, DOI: 10.2217/bmm-2017-0060.Peer-Reviewed Original ResearchConceptsAdvanced acute kidney injuryAcute kidney injuryKidney injuryCardiac surgeryPatient groupSingle biomarkerIndividual biomarkersPostoperative biomarkersDistinct biomarker patternsNT-proBNPSecondary outcomesIL-10Clinical variablesIL-6Plasma biomarkersCK-MBRisk discriminationAbstractTextH-FABPBiomarkersSignificant differencesSurgeryBiomarker patternsInjuryOutcomes
2011
Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery
Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX. Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery. Journal Of The American Society Of Nephrology 2011, 22: 1748-1757. PMID: 21836143, PMCID: PMC3171945, DOI: 10.1681/asn.2010121302.Peer-Reviewed Original ResearchConceptsPlasma neutrophil gelatinase-associated lipocalinNeutrophil Gelatinase-Associated LipocalinUrine IL-18Acute kidney injuryUrine neutrophil gelatinase-associated lipocalinPlasma NGAL levelsIL-18Net reclassification improvementCardiac surgeryKidney injuryNGAL levelsPoor outcomeIntensive care unit staySubsequent acute kidney injuryEarly postoperative measuresMulticenter cohort studyGelatinase-Associated LipocalinAdult cardiac surgeryReceiver-operating characteristic curveAdverse patient outcomesClinical prediction modelPostoperative biomarkersUnit stayHospital stayMultivariable adjustmentPostoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery
Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD. Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery. Journal Of The American Society Of Nephrology 2011, 22: 1737-1747. PMID: 21836147, PMCID: PMC3171944, DOI: 10.1681/asn.2010111163.Peer-Reviewed Original ResearchConceptsUrine neutrophil gelatinase-associated lipocalinNeutrophil Gelatinase-Associated LipocalinUrine IL-18Acute kidney injurySevere acute kidney injuryUrine NGAL levelsPediatric cardiac surgeryIL-18NGAL levelsCardiac surgeryPoor outcomeHospital stayKidney injuryPlasma neutrophil gelatinase-associated lipocalinIntensive care unit staySubsequent acute kidney injuryEarly postoperative measuresPlasma NGAL levelsLonger hospital stayMulticenter cohort studyGelatinase-Associated LipocalinCongenital cardiac lesionsNet reclassification improvementPostoperative biomarkersUnit stay
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